<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21881

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDSLEPQEPPWKKLKLSLERPYKDDSGEPIPELLDITPDGQHIYRPREDPTAAVGTKLRRIFLERGLDFFDAEKETRTSIARESQEDAEQADASPKDGESSEPSHHMTPEELFKMRLLLMPQLYVAFGEMTQARDLLTLLLSSSLSTQPSTLPPSPLAATVVTKPPPIISLQAFNAQLTIGGKDKALRSAADLFKSAADQMEQSRVFGEKYWVDALKIRRGNWGLIPAPLPLGSATGKGADKTSKDFLISYGLEEAPTLFRRRAIGRMSTLGAGSSSLEFPMRQRTRLRVSISRTSPDGTRQTSHNLLSDPDDGSLDGSLRAAQAEVVEQEVFAALIREASSLPTASAEVSERLILIDAAQNTELRFELVDGDKLRNDDREIDPYCDLVYSLLHVLLSRAHAVLKSSRLSKASIAPVPAVQPPPILQPIIDILQYREFWERVREEIDRVVAALRLAGVSTKVHYDPVADGGETLVASLLSDKSRPVGGDALLRIDDRHTLRFTTASPSTLIVHLPQATLPIASISQLTQLLVDEISSRLLSRICEIGTELCERVNGTWFVDLLSGRCVGRWEGCTLNFRINFVGDAISCSASRSGRDNRPSHVEGYRPGGQLSLLEWVRHTIESSLGR
Length628
PositionHead
OrganismPolyporus brumalis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Polyporus.
Aromaticity0.06
Grand average of hydropathy-0.296
Instability index47.05
Isoelectric point5.66
Molecular weight69319.92
Publications
PubMed=30061923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      18|      23|     440|     461|       1
---------------------------------------------------------------------------
  440-  461 (22.16/22.03)	ERVREEIDRVVAALrlagVSTK
  465-  482 (29.18/17.32)	DPVADGGETLVASL....LSDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.16|      59|     114|     370|     432|       2
---------------------------------------------------------------------------
  370-  432 (95.13/71.92)	VDGDK.LRNDDREIDPYCDLVYSLLHVLLSRAHAVLKS.SRLSKASIAPVPAvqppPILQPIIDI
  486-  546 (90.03/57.87)	VGGDAlLRIDDRHTLRFTTASPSTLIVHLPQATLPIASiSQLTQLLVDEISS....RLLSRICEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.69|      17|      17|     103|     119|       5
---------------------------------------------------------------------------
  103-  119 (31.14/19.13)	PSHHMTPEELFKMRLLL
  121-  137 (29.55/17.83)	PQLYVAFGEMTQARDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.63|      12|      26|     319|     330|       6
---------------------------------------------------------------------------
  319-  330 (20.00/11.48)	SLRAAQAEVVEQ
  342-  353 (20.63/12.05)	SLPTASAEVSER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      16|      26|     223|     238|       7
---------------------------------------------------------------------------
  223-  238 (31.23/17.28)	WGLIPAP.LPLGSATGK
  251-  267 (25.15/12.56)	YGLEEAPtLFRRRAIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.92|      13|      21|     559|     573|      11
---------------------------------------------------------------------------
  559-  573 (21.41/20.90)	FV.DLLSgrCVGRWEG
  582-  595 (19.51/10.83)	FVgDAIS..CSASRSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21881 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKETRTSIARESQEDAEQADASPKDGESSEPSHHMTPEE
2) MDSLEPQEPPWKKLKLSLERPYKDDSGEPIPELLDITPDGQHIYRPREDP
73
1
111
50










Molecular Recognition Features






MoRF SequenceStartStop




1) KLRRIFLE
2) MDSLEPQEPPWKKLKLSLERPYKDDSGEPIPELLDITPDGQHIYRPRED
57
1
64
49