<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21874

Description Uncharacterized protein
SequenceMAKRETSDPLTIYESRPPEWLPRAHTSADLGYVGFHPPRPHQIEETLTESNVKNGLVLPPAVPAETYSAQDSVRKRLMQEDALGELEDLMNQIFARKVDTIPPIPASTFRLPSRVTLNDAKRNAWFADLANPDVPLSKLGKNVPHGAKGHDLLDLLHTNNVAIPRAVWFLRVFGANDSAGLRNKPTYNPTQYSVEWANVMTTYMKKQLAEIALPSAPRPGLNIKQTFKGVLSDADTREKWISRFTYCLSLLRTFYAEGLVDNRTFLSWLVQQMSICNLAQAGFVARLGDEYLEGMLVSRALTRPFLDASLAKLKEIQDSSAKEFLANTTHILRNLVARSFLALPDAAISPRMHIQHGATLEEILMENFATEGGDSVPPQYLQNLHQTVMDVLYDVQRRNEAMLFYHLPPRVLGTLSSALSDIKLLNSISGKTDMSSVALFDDSSEVSESFSQKLDFLLTWSVTPLQYGDHRPYAAACLLQLWRNKAADRAVRRDAPSPDEPIQSLLFQWLHTSEVAGESSNLPAVALLFGQLVKHGLFSYGEYMQHLIARGEEGLSFTQPSGSISRHRDFLRWIPLHDASPSLMNQRKAILYGLRVRETPEELNEKEIRKEFRSLIPELFGGASTGEALTTTFWQSCSSLLSAPRFEQVKTIKQWFLPVYKKFLSSDTDGSFERENVILRVFTLSVIIMARVRSYGSILDMSLYTLEHVNGSPMLTAVFETLRQHMEVWACMNRMKDVASALWAVHQTWRSRGSQNRVLLKLLAEVDNDCYLEPAAREQMLSDISAYTHALFPTNENPDSVPQVLPEILLLATDPAPEAPSLLANSLWYKYMTSPDWAWKVWDNTIASLRQLPAMIPDIADRRACALRYATFLLHVDQHLPRGFDEQIRSWLLGSGRNEIAALTPEHWDVVTVVLLYLACYGALATTTILESLIFQVWQAGANVSSEEQGQSLETLLTSVNSLFEHLLLRDECGTGMPPADVFEAQGLQTRRRDVFREPHFSLLVSNFPALVLIEQNRCFSEALRGASTTLRRTMCRVSVFRQGIYRDLDAVRLTFERLLESQHISDDLHGPLLEALRLMLNDSSQDGVVNAADWRSVTSLLSHWKLAATSIEIRLAIKQLQEALSRESTRQVAGSSLDKLASAVFYSCKKAEEADFVAELITDVDRTVAGKFVNAGLKRAAEIFREWDPMRDDTNHKDLKKCASEILRLCANIVVPFRKDASLPQLDTPVQEALFTVLCAKIAHMTGVMAVVVQRPWDEYASRASQTIIFLARMLQFHLGFSITWSQQAKDLAEELCFNIARLALMHGAGEGLNMLAFPLLLDTLCFTLDEIPADAKATAPYDPFRNYPEFNLSDLPSDMPPEYKTRMRTLLPYVALNPAVEDLVYTTRDISGAIISTVPVQNRPWEWTEYLGENPAGEPARGDDRSPDGRPHVKNSAALSLELFEARVTGDRIIPPIVPAGPGLGSGIGTDDMMAEENLRSFQDDVYAEGAFSRDWRETRIRLEDASARAKAEQEDSVPPLPALTGHSHVLGAGATEHNRTSSRRPSPASSVRSAGTAPLGSVRQSPAHPLSRLSVSTAGEVIDVDALDGGTSGSGTTKKRKAMSMIVEEDDEVEFVEGPIPASQKRKIAGKPTRAKKK
Length1641
PositionKinase
OrganismPolyporus brumalis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Polyporus.
Aromaticity0.08
Grand average of hydropathy-0.216
Instability index49.74
Isoelectric point5.83
Molecular weight183097.53
Publications
PubMed=30061923

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21874
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     474.31|     126|     353|      14|     187|       1
---------------------------------------------------------------------------
   14-  148 (206.89/134.57)	ESRPPEWLPRAH.TSADLGYvgfhppRPH.....QIEETLTESNVKNGLV....LPPAVPAETY.................SAQDSVR.......KRLMQEDALGELEDLMNQIFARKVD.....TIPPIPA..................STFRLPSRVTLNDAKRNAWFADLA.NPDVPLSKLgknVPHGAK
  374-  502 (154.62/123.76)	DSVPPQYLQNLHqTVMDVLY.....................DVQRRNEAMlfyhLPPRVLGTLS.................SALSDIKllnsisgKTDMSSVALFDDSSEVSESFSQKLDflltwSVTPLQY..................GDHRPYAAACLLQLWRNK.AADRAvRRDAP.......SPDEPI
 1432- 1576 (112.79/53.00)	..........................RPHvknsaALSLELFEARVTGDRI....IPPIVPAGPGlgsgigtddmmaeenlrSFQDDVY..aegafSRDWRETRI.RLEDASARAKAEQED.....SVPPLPAltghshvlgagatehnrtSSRRPSPASSVRSAGTAPLGSVRQ.SPAHPLSRL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     683.77|     172|     353|     836|    1009|       2
---------------------------------------------------------------------------
  836- 1009 (290.50/174.10)	DWAW.KVWDNTIASLRQLPAMIPDIAD...RRACALRYATFLL....HVDQHLPRGFDEQIRSWLLGSGRNEIAALT.......PEHWD....VVTVVLLYLACYGALATTTI.LE.SLIFQV.WQAGANVSSEE.QGQSLETL....L......TSVNSLFEHLLLRD.ECGT.GMPPADVFEAQGLQTRRRDVFRE.PHFSLlvSNFP
 1017- 1186 (187.97/106.35)	NRCFsEALRGASTTLRRTMCRVSVFRQgiyRDLDAVRLTFERLlesqHISDDLHGPLLEALRLMLNDSSQDGV..VN.......AADWR....SVTSLL....SHWKLAATSIeIR.LAIKQL.QEALSRESTRQvAGSSLDKLasavF......YSCKKAEEADFVAElITDV.DRTVAGKFVNAGLK.RAAEIFR.............
 1188- 1358 (205.30/117.40)	.WD..PMRDDT..NHKDLKKCASEIL.....RLCANIVVPF......RKDASLPQ.LDTPVQEALFTVLCAKIAHMTgvmavvvQRPWDeyasRASQTIIFLA........RM.LQfHLGFSItWSQQAKDLAEE.LCFNIARL....AlmhgagEGLNMLAFPLLLDT.LCFTlDEIPAD...AKA..TAPYDPFRNyPEFNL..SDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.03|      33|     353|     152|     187|       3
---------------------------------------------------------------------------
  152-  170 (18.57/10.09)	.........................LLDLLHTNNvAIPRAVWFL
  173-  187 (16.25/ 6.80)	FGANDSAGLRNKPTY.............................
  529-  571 (49.20/25.48)	FGQLVKHGLFSYGEYmqhliargeeGLSFTQPSG.SISRHRDFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21874 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EWTEYLGENPAGEPARGDDRSPDGRPHVKNS
2) RLEDASARAKAEQEDSVPPLPALTGHSHVLGAGATEHNRTSSRRPSPASSVRSAGTAPLGSVRQSPAHPLSRLSVSTAGEVIDVDALDGGTSGSGTTKKRKAMSMIVEEDDEVEFVEGPIPASQKRKIAGKPTRAKKK
1408
1504
1438
1641










Molecular Recognition Features






MoRF SequenceStartStop




1) KRKAMSMIVEEDDEVEFV
2) SQKRKIAGKPTRAKKK
1602
1626
1619
1641