<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21871
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | METAVNGHIVNGFHHTPLQNGKHHDEPTLEDLERELPLVMDGQIPLGELVSRLSQAIYAELVEMAETMPNMSDAARKRSLADWVVRMKKQVVKLYAIAKWSRDAGVVQKAMNQQFEDAILGLKYGRDSLDPARLRNHDLLTSLDVLTTGTYRRLPACIKELVIPPTPLTDDEVSRTLADIEDAIRYRLRMSEIIPWEMSQYRIGNGRVFFTAPKLFELCLCLRGARKEDGWFFVNVTFLFTVGGDQTGMQEFPRTPSGHLKRNITDEADARLAFYLKPDEPPPPVVEVPPRPQLPEGVVDAPLVRVFNFLQMMSLSYQLEILWYQLTSGQAERLRSLGWAEYLTVEMTNKRQSMVVHYWVRKPPSTQRRRAGQSQKPLPPLGGKIVISIVHVKEQTGRKAMRSPRARVLAELQARSKLETSRPSDEVEHMRFDVRWEPEQGALGVTPAPEDMFISPGELQIDPEDLDFESLLRRVIRRHTEGVMKFFQAQLQRGPTTRNVFSPPGEVTFVSNEGSPSLRVHLCADEIVVVTVDPRTGRVTLRDTGDLAAAGRGPRFAAITERLNESPFMLPHALVALRVTTITDLAEQKVQYLGLQSFRTRNFSQDELKKLGPDAQGTLYIQLGNFPMHYLVLVITDQDFRYALINVKEVESSVNHDLKMEDIGWLNVRRIHGGDVTVEAGTGPEAIVGQKRKRDEGMAHAATSAAQYPTSFRLETKMLRELYAYCCARVAYTKVEQQFKLRSIPFTHVNSTFNSYIPEFGNVQSSLARTIPALCVQSKDILSGAPAAEAAMPNIRVIPLNWWSEDDAKVVTCVKLKYVQQPIGKRASGSTVIRPSKRIIYDTREAIVSFLSDDVDKCVDEFLEEWARVSKMVVIAREVAQMSAKYLWTDVRLISFDLQTVEFTYAADYAVSLTCTDEIQTNRSSYHLRFSRVLPDDQMQVDDIPDPTHNPHEDVELFLCNLLGYGKLSTALHRLVSLLRETLPIVAELEDIRVAAARKGESIDTFPKSAGWFRVLYGDLRHALDFRLMTGARVVILDAAHTLFDDGADGRGVRRPGKPSLSLTALSNSVALRPIPEFGTLVAEAIQAAVAHGVRGQFAPIGIGVICDVAAVRVVGRMLHQKVVEKLGQTRPSRT |
Length | 1135 |
Position | Tail |
Organism | Polyporus brumalis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Polyporales> Polyporaceae> Polyporus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.231 |
Instability index | 44.90 |
Isoelectric point | 7.15 |
Molecular weight | 127526.90 |
Publications | PubMed=30061923
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21871
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.97| 22| 315| 743| 771| 2
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750- 771 (39.78/36.04) NSTFNSYIPEFGN.....VQSSLARTI
1068- 1094 (33.19/14.02) NSVALRPIPEFGTlvaeaIQAAVAHGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.59| 22| 541| 112| 139| 8
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112- 139 (33.17/32.12) NQQFEDAILGLKYGRDSLdparlrNHDL
637- 658 (38.43/22.48) DQDFRYALINVKEVESSV......NHDL
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