<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21867

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIYCHLQVHITLSTRTPSTARLVIQPIMQPTYYLPLYSSLPLPAGVPVVLLPHGVPAYYLSTYSGPSAALTVQFNDALIGLGAGDWKRPMYPRAPASDPSSDNPTYIVVWLAVQNKQGEDKGMPIIWPASLCVSYHASSPSAHARSSLPYIPELPAQLQASPPPPTATIPPSLSFGSAASPSTDIPPTASGPSMPSGERDRLASSLKRRPSLLRSPLIGDSLRAFRALSLSRKPYVRNVRKVATEVNGYVDSVVKERERERERYRREKEQEIALAKAKLADTRPPPQTEAPVALTTSSEPALTPQQEATTVMPATPSVSAPAEPTEDSSPAEESDHSADSLFSPPDAAIDLPSTEEETQIAPDVPAGDDAPPLPAEAPTTAILPETRVGSSSANDDMFHAFDSGWSQQSNGYMDMDYEMDFDMNLDPLGGARTGAAGGGFELDDGLPFTDDDFAFFNAPSAQPGVAPSTYPPPLAPVVGMVSASAPSLGLTPLTTMDVTLSGPGPPSAGSALPSPWPPLLGEPYTPKGSVDMHGTLDGVAPPDLLPPSPAGTPSSHSAPATPAVHLTEVYHTGDGRNLYGMPVSFNIFDPIPFASSHRQLDGKYAVGKFALPSPPADQDGAASWVHESPVSTVISGWKYKYSAVTDPRIGVVRKLIGVKRKSLDQGTRDQRKARLWDSYREREDWQSSSPPSAEIDSEESDDDPWMEEDEAPSVVAAAPRPSTPPPSYLPVGPALLRTHFHHTHLLPMCAPLRPPGIVVSNTPGNTAPMSVPTPVSPAAVLGAASEKSKSLEAAAQILVKEVIENPVWAEAWRANASLSFTPPMLPCKAWQADARYIKHLIAGDGLPTTLQTILDTGVKSEDKFGRASLHTLESPMLALGKGDAVIQLSPASLRFWEKLGLTPRAGPKDVTAFVFFEGSDEERENEVENWLGKVSAAYSAKSFGAHDVGMSSHCTKQGVVPTRFDTFRKTLMSFVSTIPTRHPNLVFYVATPSHIISSSSTTLRQILSAVRRLYKAHPDGDILVHFVPESLILGTHAHPASKLDGLDTFVCSVYDRILRPVTRAMSRKFFNWSAPVVGYFEAPAYALVASPSNKGSHGASHPKVSYSLESSASSLDVTLRHMLLHVGYQVSACGRWIIAACIDAEGEAHELKTWLTPEDNVEAFLASEVWKFGYEFAQRANVEWRIVISKLGLMTHSELEAWVSHLESVVTASTNAPPVHVTLLAVDNENPWTFLSAPEPGSFDVLKRTPSPSPQMPSKSRGNHTTFSDAAYTTYFLVPSPEASLYPAYTAERTNKCGPFHHIPGSAEIPYIPDLEDEETSGAVQSHTAEPIRVAGWSTVVCAPSTDDRTSLSTVRLYQLHTTRSSRSTYGSSRPRGGSFKGPSDTTMDDELMSDIVRNFHELAVLSRTKWKLSADPALPFHLAALEVMRAALSGDAVDL
Length1440
PositionKinase
OrganismPolyporus brumalis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Polyporus.
Aromaticity0.08
Grand average of hydropathy-0.267
Instability index55.73
Isoelectric point5.51
Molecular weight155079.80
Publications
PubMed=30061923

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21867
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     866.78|     178|     184|     257|     436|       1
---------------------------------------------------------------------------
   72-  200 (166.06/44.57)	VQ...FN..........................................................................................dALIGLGAGD......W...KRPMYPR.AP.ASDPSSDN.....PtyivvwlA..VQNKQGEDKGMP....IIWPASLCVSYHASSPSAHARSSLPYI..........P....ELPA...QLQASPPPPTATIPPSLsfgSA......ASPSTDI.PPTAS...GpsmPSGERD
  220-  395 (261.56/73.83)	DS...LRAF.RALSLSRKPYVR..........NV......RKVAT........................evngyvdsvvkeRERERERYRREKEQEI.ALAKAKLAD......T...RPPPQTE.AP.VALTTSSE.....P.......A..LTPQQEATTVMPATPSVSAPAEPTEDSSPAEESDHSADSLFSP..........PDAAIDLPSTEEETQIAPDVPAGDDAPPL...PA......EAPTTAILPETRV...G...SSSAND
  396-  579 (217.25/62.87)	DM...FHAFDSGWSQQSNGYMDMDYEM.DFDMNLDPlgGARTGAA...................................gGGFELDDGLPFTDDDF.AFFNAPSAQpgvapsT...YPPP...lAPvVGMVSASA.....P.......SlgLTP....LTTMDVT..LSGPGPP.........SAGSA..LPSPwppllgepytPKGSVDMHGTLDG..VAP..P..DLLPPS...PAgtpsshSAPATPAVHLTEVyhtG...DGRNLY
  580-  788 (221.91/61.68)	GMpvsFNIFDPIPFASSHRQLDGKYAVgKFALPSPP..ADQDGAAswvhespvstvisgwkykysavtdprigvvrkligvKRKSLDQGTRDQR.......KARLWD......SyreREDWQSS.SP.PSAEIDSEesdddP.......W..M.EEDEAPSVVAAAPRPSTPPPSYLPVGPALLRTHFHHTHLLP..........MCAPLRPPGI.....VVSNTP.GNTA......PM......SVP.TPVSPAAVL...G...AASEKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.59|      11|      16|     806|     816|       2
---------------------------------------------------------------------------
  806-  816 (22.86/12.81)	PVW.AEAWRANA
  823-  834 (18.73/ 9.16)	PMLpCKAWQADA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     385.67|     120|     290|     961|    1083|       3
---------------------------------------------------------------------------
  961- 1083 (204.03/137.57)	PTRFDTFRKTlMSFVSTIPTR....HPNLVFYVATPSHIISSSSTTLRQILSAvRRLYKAHP....DGDILVHFVPE......SLILGTH.AHPAsKLDGLDTFVC..SVYDRI.LRPV......TRAMSRKFFNWSAPVVGYFEAP
 1240- 1383 (181.63/110.95)	PGSFDVLKRT.PSPSPQMPSKsrgnHTTFSDAAYTTYFLVPSPEASLYPAYTA.ERTNKCGPfhhiPGSAEIPYIPDledeetSGAVQSHtAEPI.RVAGWSTVVCapSTDDRTsLSTVrlyqlhTTRSSRSTYGSSRPRGGSFKGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.95|      22|      23|      17|      38|       5
---------------------------------------------------------------------------
   17-   38 (42.27/26.40)	PSTARLVIQPIMQPTYYLPLYS
   43-   64 (40.68/25.08)	PAGVPVVLLPHGVPAYYLSTYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21867 with Med13 domain of Kingdom Fungi
Unable to open file!