<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21865

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMDEDMDMEDLFGDSDGLSLPSRPPSKELYQRVDELRRGGCCQGIAWSNWGCIATIAVDGASLELRNLRCHPENGIWGLSEPFVTPPFTPTLEGGPLKHLCWSPSGSELAVIDTAGRVNILTLFSSLNKPTLHRHGQIDPADDLYGVVGCFWLNVAPYSPNRPSFLNGPAVKEGSTYRYEGSQAPVFGPFHPVHAKSAFVCVTTNGLLRIIFPQTNGKWSEAHTELESVVSSDDLITHAAICPDKNNTLLIAFATTSKQLRVLRALVDWGQPKPTGGNHAATQPLNPTIKTRHVAATSWLHDAPGETLNASNMDSAMTQLSHLKFLPSCGDSHGRTTPPTIVAIRSHMPASTSHYNQDVHTTVDRWEIREKLQTVHPAFEQLSSRKNSVGSPPGPTFFLKKLESLVINKTLLAIQPMNLGKVIIFAYSDSSVEYRDRSTMAETFTDHDLDRVHHLSQIGFSYAEDEPCLQVALSPSFCSLVQIRNDGKVKWKQLEYRLGEIGSSMDDPLYAGIVAALALSCSTAVMRNVTYDDLLATAHKLSKSNLAFDWLIELSKILKAPVDYSEEQHFDVLIRNTAIQLCLCIQNSLGFHGEFHPRTFPGKFAWLVLQLRNIVVLVTMAANLNVPDGSNPNTKTSPLEDPEVINALAGSVRWILDLMAWLTDTLLTLPSTLPPSMDLTKPDGFKLPELLAHLRSSNTISLHMLLSSPTRGFLTAICRRLSHLDWIARRAIMQSSSNPASNPPNANPSQANSSSISPALRNAYLQIATLTTNTILRIKTIETLLGSLTSNIKEAYRNASPSLAGRPAEAARNTLETKMLFGGSFPDAFKPVIVELFRRGGLLETVRDDIEPAKLFFADFSLLEVDEDAASVAKRKSSGMTMDCFRKTWLENPKKRKGGNGGGRQDAAAGGDANGSGNPPQDGAGGGRQIARWRRCARCAAVMEDVLTERRVLQWLIMQQRRCFCSGWWDTLASGETVA
Length982
PositionTail
OrganismPhialophora cf. hyalina BP 5553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Pleuroascaceae> Venustampulla.
Aromaticity0.07
Grand average of hydropathy-0.203
Instability index47.44
Isoelectric point6.72
Molecular weight107816.66
Publications
PubMed=30018880

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21865
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.61|      26|      53|     607|     632|       1
---------------------------------------------------------------------------
  607-  632 (44.26/25.75)	FAWLVLQLRNIVVLVTMAANLNVPDG
  662-  687 (47.35/28.03)	MAWLTDTLLTLPSTLPPSMDLTKPDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.40|      50|      53|     277|     329|       3
---------------------------------------------------------------------------
  292-  343 (80.09/53.97)	IKTRHVAATSWLHDAPGETLNASNMDSAMtQLSHLKFL.PScGDSHGRTTP..PT
  347-  399 (77.31/53.96)	IRSHMPASTSHYNQDVHTTVDRWEIREKL.QTVHPAFEqLS.SRKNSVGSPpgPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.82|      14|      23|     895|     910|       8
---------------------------------------------------------------------------
  895-  910 (24.40/17.76)	NPKkrKGGNGGGRQDA
  921-  934 (29.42/15.34)	NPP..QDGAGGGRQIA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21865 with Med16 domain of Kingdom Fungi
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