<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21864
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MASIPNEFPISLKPKPLRPTEPTLPTLIQRINFERGGFHNISEESLRQEIAEAGRTGSRGGEKGTTDEEEEDEEDDDDDGEDGEEEPDRMKELMKAREEILGQIDGAYQSAAYALDFVSLLLSKDTPVQASLSMSPALKELVGTGTMGADKIQASRVDANQKADNKRIAKGWKVQNLNKAVDTIVDSATRLEKEIETETKYWEQVLSVSNKGWAICRIPSEKQTLGVRFGFPEAAPNFRNQSLAALRRNPDGTIYIEQGITNAEPQTLRVRIQVNQTDTGSSSLSKPAAADAPVESLILQARNTIFNTELWQELNREARGLGAFGVRGIEDTLTLPLSPSKTIVLDLVPLADSSTILPQPDDSIAEGICLSLHILLSFAHRHNHRRRTQPPPPISNQKRPNPPYSLLRPLITRLNHQQSNSSLNSLLSSLCSALSSTKIYPAPSYKITHSSPQAPPIPNVSTSELTVIALTDRLESIANFVITPTTTITIACRSLQVPLAGTSFHLSLNAESPLTTTCVAPPVLGHISAVEEYILYATSCALASNIISISEQQSETEETDLSKNGKAGWHLTAQPNVLRKVFKGGKGKQFISSVNNEDGKGCKVRVAWNWMRHDFYGIDKEGLGAEEERRITGEGMYEWNSRLGNSAWAGGEGEVVRSLVDVVESAGVWLT |
Length | 671 |
Position | Head |
Organism | Phialophora cf. hyalina BP 5553 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Helotiales> Pleuroascaceae> Venustampulla.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.419 |
Instability index | 55.85 |
Isoelectric point | 5.28 |
Molecular weight | 73446.69 |
Publications | PubMed=30018880
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21864
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 105.20| 32| 41| 402| 441| 1
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19- 53 (49.18/23.05) PTEPTLPTLIQRINFERGgfhNISEESLRQEIAEA
402- 433 (56.03/43.75) PPYSLLRPLITRLNHQQS...NSSLNSLLSSLCSA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 124.20| 39| 146| 337| 375| 5
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337- 375 (66.44/55.48) LSPSKTIVL...DL.VPLADSSTILPQPDDSIAEGICLSLHIL
482- 524 (57.76/47.01) ITPTTTITIacrSLqVPLAGTSFHLSLNAESPLTTTCVAPPVL
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