<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21856

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGEYRTNVLSFNNFASIKYEYLEPDACYPGPARKPLQRAEAAWRQAGKLVHHDTLRDGIWVFQNTNASNSSADRPGDNGIVTENGIGEAQGVQLVVKAKGIFEPASLIRSKQATPALYSASSNSSPSSSLENPVRNAQALNARSVSANALLNPSLEPSATSPGLKSPNKTEDMWPLMKDVHENFISAALGSLVYLLCRDEGFIPLNPRTLISGYPKSPDKTWPQGANATTLATLDISLTSLGTLVIKAHSDAASGLQGLVNDSAAADKLAPGAALWLAPGGNAAKYYSQQDDKAKLLTAPASSVTSDSRPITLDGATFKTWQSNCLEWLSAKGIHTAPIESGGWILVQILVGHSPYLNAEYQGIPILEGRTVVPWPAALCFQTASSGTLPASEKPISGNRDPLAFSEEWYSGKDDRAALILKRQKERQVAEALSIEQAEVEARALQSGTFSPAVLRRGSNAGAMYPTPPDAIHHTVGVTPSFDGAGSTPGNVNPFNIHDGTMTAPTNSGMSENDVDMWASAEKKERTSLNPHFNDNDNDADNLFGDLGGDLFGTADITEADFNFFDEPDDVQPTQMTGTPGPSNVITAQETLAFEDPFSLNSAKENGMGPPNAIVRNQNNQDTTDPSSEQLEASRMQVAQIGTKNFMLENTETSSSCKQGKPSSAPVKPNFNQEYIYQQLVKELDTGAPKTPARKASLFNKINFENTLSSVDKKYGAHGQYTFTGDKKHLKPLDALGIPQTEYLNARRRVPINEQESANLARVLVEENVAGPPESTDPMDFLMDSDCMSQVSEQDDSSLTAEDTVSKNIVERNWLGDNGSGDSISASFDAMAMDFEQSASTPQSVPGSQMLLFDADPADWSLTTYFTTPEPEVQSDTLSDLERIATAQILADQAVSGTLQLPRISGSESPTPVNKTTITRGLVRTLAKVAKVLFEDITPCTMRSFLEIQGIPVLNQGLRLPPRPMNPRAPNTPDPARSNNPFSLPPPQLELRRSDSKLSILPAAVRFWDNLGLAPSMGGKDVNAVCIFPDIAGVSTNANTFLEQMKSSYESYRLGNHDRATSKDIVDGLIPFSVESDHQDGPRYLATLQETVARLSRALCSLTVEEKNFVVYFVYPVDSPTLLVHICSAFQHLFNLYRKALADKKMRASNELVLQLIPGDFVASPTSIVVPLPSEYARLALEVYDRCVDFTSSTSSPAIMLEQPLPKSIDFKLSPYPSPSLLQENTCLHIAYAQSIDDRWVAAVWTDNRGTQQMTASYCLGRKSEPLSMHFSEVAHEIWETTLDFISSKKIHWRIMIARVGVMDPSEVDFWTGLAATESDAHINLTLIAVQTDPSLRLLPPSVTLTISGNGPQAVTPVSTPQSVPSIMSPDNSTTPARETANAATPGDAPVEPDRDARLIDYTDQSWGAVLSHRLNNSNSLLELNPALISGYLIKRGGTYSDDTPIVIEVNIVHSEVVGNPRTFHESLLREILGYYRGLATLARVRGMVDPVKDGRPWHIAAAEKAVKTLYMLM
Length1516
PositionKinase
OrganismPhialophora cf. hyalina BP 5553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Pleuroascaceae> Venustampulla.
Aromaticity0.07
Grand average of hydropathy-0.335
Instability index42.22
Isoelectric point4.99
Molecular weight164585.69
Publications
PubMed=30018880

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21856
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.52|      39|      49|      65|     110|       1
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   65-  106 (62.63/52.30)	QNTNA..SNSSADRPGDNgivTENGIGEAQGVQL.VVKAKGIFEP
  114-  155 (55.89/29.92)	QATPAlySASSNSSPSSS...LENPVRNAQALNArSVSANALLNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     325.60|     121|     442|     380|     594|       2
---------------------------------------------------------------------------
  437-  470 ( 1.58/85.97)	.......................................................................................................................IEQAEVEARALQSGTFSpavLRRGSnaGAMYPTP
  487-  584 (134.98/84.74)	AGsTPGNVNPFnihDGTMTAPTNSGMSENDvDMWASAEKK.ERTSLNPHFNDNDNDADN...lFGDLGGDLFGTA....DITEADFNFFD.EPDDVQPTQMTGTPGP..............................................
  772-  914 (189.04/102.97)	AG.PPESTDPM...DFLMDSDCMSQVSEQD.DSSLTAEDTvSKNIVERNWLGDNGSGDSisasFDAMAMDFEQSAstpqSVPGSQMLLFDaDPADWSLTTYFTTPEPevqsdtlsdlerIATAQILADQAVSGTLQ...LPRIS..GSESPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.42|      29|      51|     684|     713|       4
---------------------------------------------------------------------------
  684-  713 (45.54/30.86)	KELDT.GAPKTP...ARKASLFNKINFENtLSSV
  733-  765 (40.89/22.85)	KPLDAlGIPQTEylnARRRVPINEQESAN.LARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.77|      52|      53|     278|     329|       5
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  224-  277 (65.04/32.01)	W...PQGANATTLATLDisltSLGTLVI..KAHSDAASGLQGLVNDSAAADKLAPG.AAL
  278-  329 (86.94/45.14)	WL.APGGNAAKYYSQQD....DKAKLLT..APASSVTSDSRPITLDGATFKTWQSN.CLE
  330-  384 (71.80/36.06)	WLsAKGIHTAPIESGGW....ILVQILVghSPYLNAEYQGIPI.LEGRTVVPWPAAlCFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.94|      36|     141|    1178|    1253|       6
---------------------------------------------------------------------------
 1178- 1213 (63.45/88.82)	YARLALEVYDRCVDFTSSTS.SPAIMLEQ...PLPKSIDF
 1273- 1312 (56.50/17.00)	FSEVAHEIWETTLDFISSKKiHWRIMIARvgvMDPSEVDF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.42|      18|    1216|     198|     216|       7
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  198-  216 (31.11/21.63)	LCRDEGFIPLNPrTLISGY
 1417- 1434 (30.31/16.26)	LNNSNSLLELNP.ALISGY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.48|      50|     400|     948|    1000|       9
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  948- 1000 (84.41/47.04)	LEIQGI.PVLNQGLRLP...PRPMNPraPNTPDPARSNNPFSLP.PPQLELRRsDSKL
 1347- 1401 (75.07/33.95)	LTISGNgPQAVTPVSTPqsvPSIMSP..DNSTTPARETANAATPgDAPVEPDR.DARL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21856 with Med13 domain of Kingdom Fungi
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