<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21851

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGARQGPHTNHDRDQRPNGLNGANANHLNERLLEKGKGRAEPQQNVTPTSPTIPNGIHGGFAKSPRHQAGVEGTTLKDGRSQMDQLPPEIVHITQGYLSLSTLLARLAQKTHNDLSKTVLDLAQMPLPASVANGNASHITTVDDNSAENLAKKLRLLKFSQETHTEWTKALVITNWSRRSEDVSKMIDAKVHLDQQKAFYDFAVHELSEVKRSLMHARLPNPDIKTALEVLTTGKASWMPDLGYIEPPPLTAHEILKSLESLNTLLSIRLNLHEYDNIPIHFREYTIKSGRVTFKVEGEFEVDLTIADDDPETQFWFIDFRFLFSPAISDLAPHIRGFIESRVNEALLRGGLPGCYNFLHGMVLSHKISEFRRQAAGLARGKWVESLKVEALNRALSIQYWLDPYGRPGPKSWIILGVHSGKRKVGVRHPKDTSRLSIRWFRDSKEVKEVDIPFDTVNISTESLLKTVIAKHVNHILTSTYEKLRAKPLFASREAVLALTTSNDEPAESELRVQLTNERHVSIRIEPITGRFIFSPASRVTTEFEYRINRSVDPATDAHTYIDGLRHAAITEDIVIRGLSLGWIRVDNPGLRQDDLKAVIPKDASQVVWLRRPGWVKNWYIAISMSMSGERWWLIETTDPPAEASIAPTTKKSKKEANVKINSALGIPIKSPSPTPTYTFLTTLHIFAAALLSHYANLKSLYGKRVHYMPHESNKLPTPVKLPAIYIRLSELINSPKAFKKDLVKLTFQGLEGRRVPKQQTLALTPSSQSPATPLAQENAYIITEARISMPVPAALRDIKERIDPDIAFDYETGSLALRLRSQVGESVIPNLIERATRVHRLLKFVRVLQDHEKQLKCETISLGKIVFTYGKIKSQSNPDAMDVDQAGPREYKAVVDFGGTGGSMALVLEPGNPHLHIGDYLNRILNGSEGLNGVATLLPLTLPVLFAIDSIETSWASIPRSKGEAFMLVRSTDWYIVRYNLPTAQPPNPTLPPRSRKIMFVVKLRQRRGVPWWDVRRIDSRDKNGDDLDTALKPIWNSSGHGWQGMRVSAVAQASGVEELLSKMDEVVRNFALAQETTGLPQQSLANPTPKARPQVPGQQQQQRQQPTPNHSQSQIHQSQGRNGSMKREVVEID
Length1137
PositionTail
OrganismPhialophora cf. hyalina BP 5553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Pleuroascaceae> Venustampulla.
Aromaticity0.07
Grand average of hydropathy-0.418
Instability index48.03
Isoelectric point9.41
Molecular weight127393.91
Publications
PubMed=30018880

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21851
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      15|      20|     308|     323|       1
---------------------------------------------------------------------------
  308-  323 (25.33/24.30)	IADDDPETQfWFIDFR
  330-  344 (27.19/19.29)	ISDLAPHIR.GFIESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.60|     108|     208|     403|     513|       2
---------------------------------------------------------------------------
  403-  513 (175.79/109.65)	WLDPYGRP...G.PKSW.IILGV.H.SGKR..KVGVRHPKDT................SRLSIRWFR.DSKE..VK...EVDIPFDTVNIS.TESLLKTVIAKHV.NHILTSTYEKLraKPLFASREAVLAlTTSNDEPAESEL
  526-  609 (55.21/25.87)	RIEPITGRfifS.PASR.VTTEF.EyRINR..SVDPATDAHTyidglrhaaitediviRGLSLGWIRvDNPG..LR...QDD..............LKAVIPKDA.SQV...................................
  611-  724 (131.60/73.71)	WLR...RP...GwVKNWyIAISMsM.SGERwwLIETTDPPAE................ASIAPTTKK.SKKEanVKinsALGIPIKSPSPTpTYTFLTT.L..HIfAAALLSHYANL..KSLYGKRVHYMP.HESNKLPTPVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.79|      12|      16|    1082|    1093|       3
---------------------------------------------------------------------------
 1082- 1093 (23.36/12.97)	GLPQQSLANPTP
 1101- 1112 (24.42/13.89)	GQQQQQRQQPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.75|      14|      15|      96|     109|       4
---------------------------------------------------------------------------
   96-  109 (23.06/15.01)	TQGYLSLSTL.LARL
  113-  127 (19.69/11.74)	THNDLSKTVLdLAQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21851 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FALAQETTGLPQQSLANPTPKARPQVPGQQQQQRQQPTPNHSQSQIHQSQGRNGSMKREVVEID
2) MENGARQGPHTNHDRDQRPNGLNGANANHLNERLLEKGKGRAEPQQNVTPTSPTIPNGIHGGFAKSPRHQAGVEGTTLKDGRSQMDQLPPEIV
1074
1
1137
93










Molecular Recognition Features






MoRF SequenceStartStop




1) KIMFVVKLRQRRGVPW
1000
1015