<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21850

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMPSDHPQTPESPTHTSSVATDPHTKASTSPQFTNSLPTPAHSINGSMSSLASEIVPEGALHVESSNKRKRDPEDHGNREQKKVHVEDSRLSIEDLHLDVGEKYLLCRTPHPGQRPQLSQDLFGLYGLDSIAQSVARTNPDGSKNPLRKTYKKYIKTLGLSGAFDVGKKDVDAPDTLFALLSQPDEEWEAQNARGQEISSGLPEAVKASMGAALKMSRGKISKSSWDDSVLGEIATRPPPEPAKVIHNAARNPVSQNVGMARPAKGDIPRPKRNVKKRSYGDSSFEGYGEGFVDDDNQDTGYSTGEGDDRSGRKRPKKSAPGHSFQGPVRQTSYGPGMVGV
Length340
PositionHead
OrganismPhialophora cf. hyalina BP 5553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Pleuroascaceae> Venustampulla.
Aromaticity0.05
Grand average of hydropathy-0.894
Instability index49.71
Isoelectric point7.84
Molecular weight36769.29
Publications
PubMed=30018880

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21850
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.39|      24|      44|     269|     292|       1
---------------------------------------------------------------------------
  269-  292 (45.93/31.10)	RPKRNVKKRSYGDSSFEG......YGEGFV
  309-  338 (41.46/27.28)	RSGRKRPKKSAPGHSFQGpvrqtsYGPGMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.10|      13|      15|      11|      23|       2
---------------------------------------------------------------------------
   11-   23 (25.16/13.14)	SPTHTSSVATDPH
   29-   41 (25.94/13.74)	SPQFTNSLPTPAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.25|      17|      35|     202|     222|       3
---------------------------------------------------------------------------
  202-  222 (23.24/27.43)	PEAVKASMGAAlkmsRGKISK
  239-  255 (31.00/22.72)	PEPAKVIHNAA....RNPVSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21850 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPSDHPQTPESPTHTSSVATDPHTKASTSPQFTNSLPTPAHSINGSMSSLASEIVPEGALHVESSNKRKRDPEDHGNREQKKVHVEDSRLS
2) WDDSVLGEIATRPPPEPAKVIHNAARNPVSQNVGMARPAKGDIPRPKRNVKKRSYGDSSFEGYGEGFVDDDNQDTGYSTGEGDDRSGRKRPKKSAPGHSFQGPVRQTSYGPGMVGV
1
225
91
340










Molecular Recognition Features






MoRF SequenceStartStop




1) IHNAAR
2) KNPLRKTYKKYIKTLGLSGAFDV
3) KYLLCRT
4) QDLFGLYG
5) RKRPKKSAP
245
143
102
119
312
250
165
108
126
320