<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21848

Description Transcription mediator subunit Med12
SequenceMTTRPPLGQRQPPQRSLSATNAVQRPPANHRSLPQQSSSSSPTRRGNETFVDLTYDGADPVGGRYGAATTVPRNGGSRLKLEISDSGTDSQAESPKPAPDVAPIWRPSAPPRGRPRTHFDVLNASSLGFRAGQDGLQGDAQVKPMPLPVRPRQHAPPVSGGKLLEKSGSPARKDGRPKPYTLEVPPAAPRYPPNGHVDFYPWTGNHPEDHFSESVIRQGYYDKAQMSQNETGSAKSTVFPALKNKTGLQTLSSILTSVLAQRKAHGQITASSTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAIWLAKCVGANELRSFRRKGVSGTFAMGGEAKWIRDFTVCVEQFIESILGTCGEGDFKTKIDYAIRLASHFHAEFLLDREHYMDWLVSSLENSPQTKLPLWILITQIYWKDLLKYRKYGRRLSGAFLHHYAELLNHPDQDILAPLSDRLHRLIKSLMVSNPDGFVSPAVWTKHRDIIRSGLVSDDERFLAIFESIDRRNCRLGISGSGKEPTVRQRIIQLLDTTLSASPSDDLPKRCWQITDDKAMVLRVVLEWSTSLYRPGIPKTYVAARILRFGAKSGADVTDALLNFMDSETCEVGRNRLSFYHLVSELARSEHFSAARYFQWLIARGGLQDPADIAQDGPCAKRLLAELPTHNLSEGIASLHRALLERASFSLDEEEERMAGCMAAINRTLPTMPGSDSEMELDNPHMSDDIPSLISQLNRSSKSEIGLWLRHKVLLQMQQPKIPQLDDWDATSVKAATPAIATSDFQKIRYYLELIEDYSMLADVLKITASSSDAEVLATCTDTLNLHVDTLAAIGALQSLFDMLVARLRVLAQDQDSIPRVFLASLSDLASRMPNQKRLAQQLSQELVLCDRKNAVDACSPVSDHIAITQATEVDFIEETEKILSNGNSMDQATLDRLFQRVVSHLEISWHKSPDQQRCCVSLLARLRPFSTAHFDTLMSSWVTSFLHMHNRPSMFRVLGPFISSGCLSLSTIASCCTSFLGKAVSDDHSATRISRELLDLLIGTVNSEEVMDVGEAYRFRVKQSHMQKDSATDILTIIRRVLEEPPIPASDESNFPADDGSSLLENRNAWELLQRYALLYTDSVIQILATPLLRNSGSAGSASLSTLINKFLLGETREDDISTEEILDIADDLTLPFCQIQLDSMFGAEDSAMSGTDESVSARFQTFDSAIEAAVNSGKTAWASIVPLLDMSIAQHLRRRAELQFLALFPSPKSGNVLDCLTTGNHLAQAENLLRVIDSTAYSTSTTATVNPNNTSHALDILSTLNSIRLILSTNQTMQIKDALISKWIPLILSFIVLHTSEFEATKSGHENRAKVTLALSAVFLELQALDINTEPVSGLIQQTFDLALHLVDGLPDDVRQQCIRSLHDMVSNPQIRYLFSYSSNPSDWLVLSQKEKPSSIPGEAPRRRTAAEKEKIVPFRLRRWEMLGEPTPNIGENDTSLNLTLFGARRG
Length1509
PositionKinase
OrganismPhialophora cf. hyalina BP 5553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Pleuroascaceae> Venustampulla.
Aromaticity0.06
Grand average of hydropathy-0.289
Instability index50.08
Isoelectric point6.47
Molecular weight167472.37
Publications
PubMed=30018880

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21848
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      13|      19|       4|      18|       1
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    4-   16 (26.91/ 8.60)	RPPLGQRQPPQRS
   25-   37 (26.40/ 9.39)	RPPANHRSLPQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.69|      31|      33|     127|     157|       2
---------------------------------------------------------------------------
   86-  121 (45.20/19.58)	SGTDSQAESPKPAPDVAPIwrpsaPP...RGRPRTHFDV
  127-  157 (58.11/27.08)	LGFRAGQDGLQGDAQVKPM.....PL...PVRPRQHAPP
  163-  193 (44.38/19.10)	LLEKSGSPA.RKDGRPKPY.....TLevpPAAPRY..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.48|      25|      26|    1282|    1306|       4
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 1282- 1306 (39.73/24.59)	NHLAQAENLLRVIDSTAYSTSTTAT
 1310- 1334 (39.74/24.59)	NNTSHALDILSTLNSIRLILSTNQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.92|      10|      26|    1346|    1355|       5
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 1346- 1355 (16.56/ 9.91)	IPLILSFIVL
 1373- 1382 (15.36/ 8.61)	VTLALSAVFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.74|      30|      31|     974|    1003|       6
---------------------------------------------------------------------------
  974- 1003 (55.70/30.28)	RCCVSLLARLRPFSTAHFDTL..MSSWVTSFL
 1006- 1037 (52.04/27.84)	HNRPSMFRVLGPFISSGCLSLstIASCCTSFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.85|      10|      25|     532|     541|       7
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  532-  541 (17.97/ 9.25)	LGISGSGKEP
  555-  564 (17.88/ 9.16)	LSASPSDDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.02|      46|     381|     270|     340|       8
---------------------------------------------------------------------------
  270-  320 (65.34/35.59)	ASSTFKPPPRVTVTDTKREMWLKDLANPTISL.RRLSRSIpHgirgKVLLDQ
  659-  702 (68.39/25.51)	ARGGLQDPADIAQDGPCAKRLLAEL..PTHNL.SEGIASL.H....RALLER
  723-  756 (35.29/30.62)	.....RTLPTMPGSDSEMELDNPHMSDDIPSLiSQLNRS.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.95|      14|      19|    1203|    1216|      11
---------------------------------------------------------------------------
 1203- 1216 (24.46/15.49)	FGAEDSAMSGTDES
 1221- 1234 (23.49/14.58)	FQTFDSAIEAAVNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.51|      28|      35|     384|     412|      13
---------------------------------------------------------------------------
  384-  412 (43.77/35.49)	EGDFKTKIDYAIRLASHFHAEfLLDREHY
  421-  448 (50.74/35.68)	ENSPQTKLPLWILITQIYWKD.LLKYRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.16|      63|     563|     833|     896|      14
---------------------------------------------------------------------------
  833-  896 (100.80/62.79)	LATCTDTLNLH.VDTL...AAIGALQSLFDMLV.ARLRVLAqDQDSIPRVFLA.SLSDLASRMPNQ...KRLA
 1397- 1468 (89.36/51.23)	LIQQTFDLALHlVDGLpddVRQQCIRSLHDMVSnPQIRYLF.SYSSNPSDWLVlSQKEKPSSIPGEaprRRTA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21848 with Med12 domain of Kingdom Fungi
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