<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21828

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLNTTAMNATDLLKSCPTGVQILANLETIMFQTLTIEMKDDAEEEGQGEAIAAAIATLRAWSFFAYLESSKRVLWIFHGGSLTNGFATRPDITKIAQDWPFQLKNFHKGSFKASEVSTSRPPPSAPNAPPESCIPISKVTPAIRHAQMMLQKSLKALAAPTGTAVDPGIIPTHIQAVYSKFISAVYLTVSHKLARDDRWIEVNPSTYVQLPEDWNVRKDTPLQCFSLDIYLAGGGQLVISTNTLEDSTFRPCYELDSYSDTLEPILLAPGGMPAVVNDDCIAPENKASQIWKETVSNLLATRGIQLNVLDPAIHWVLVRAWPSATTADSDTTLGTVFYWPRALCFRTSPPASDGSQSTFEFEDQLEDPTKISPSSWFYSAKEGGFLDSLQFAEDWFGGKVERDKIVQERQKKRKEMEAAVQKQVEPAALAVASPFYTRGDLQAAGGMYPTPPDGVISQPGTVPASADAIPAIAAHDTPVPRTGLVGDGMDMDEMFGETLKRRATIESRNSIQMDVDMDRDDLFDAIDEDEFTGHDIIDADFDFFDEPDDDMLGAASSVPDVPTKAPPIHEPQVIPIAAIQPSHPPPEPDLFSALEQAMGSTNEVAVPEPDAPKQAPDQTPAAVKVEAIIMKPPLSPTSVRKKLFDETANDHTISRRRGSQYDPVPFKPSLVSEDTKYSTGGTFGFSEKEIADLAKHSTARTETDIALPPRKRPRTRRRQPKDSDESSDTSDASDDDSLSDEIESLALASSPVKGIFFDKRITALQDGDVTSVATSPGSYMAIEDHPASGMSGSLQDRIELLDAILNAPSSTIPPSALVRQPNESDGMFMLNPTDLPVTLASTTALDGPLSLSNKDFILVAQIIAEQLIFSSIDHSLQLTTEGQGMMDALPVKSYSITTARAAQTALKSFHSGLTDCDFFKFLCLSDHDRPQGAKGQPQPQAKKVSPQAAEFSIATINALTTLPPPHVRVRRNEGLWDILPPAIPFWEHLGLAPASGRKNLMAFCIYPGGQDVKSQVCLFMENLGASYESCKLGAHFRSDVQKSAPIQIEQGLVPVTLTDQDESIDLAIRRMREVCVDLGKHLSTLDTQQKKSTSTPANEEPPPIDNFIIYMVNPFTDGRGIAELCAAFWMLYKAYSPPRSPQLDPRPDLVLQIIPIADVANPSTPVIHSSLYFQQMARRVYDRCPPSRSFHDSDPTPLRIVSASSVLLESPIPKKIGFLLSTDPPADLLNDQPHLHVAYAISENGEWVTAALTCLTGRYQTTVSYCLAGGRPFWDVAREIWSVALSVMRERRGAWRLCVVRVGRMTCGELDAWSSLHSSPAPFNIIVCIMSIDPSPPVTIFPPASSPSTLPLIDKSTPVSTPQPGISPDPHALTPASTPSANVDSAAADPANDKDAHLVDRGDEVFGLISGCRVNILGGKGEYRLSLSTGYMFRSPAACKSRPGVTEGFEGNGSGDVGSGGGVKDERVGLVGVHLIWVGQPPRGGVQAQQAQQQQQQNQQGGAQQSQQGGQGFSPIDPSLPQTPGASIPANEAGQRATMTTTNQPQIHRSMADSILKDYLVLFRNLAELARVRGVGDGDGVEGEGVLPWHCLVALRGVRGLQRTFGNLNDG
Length1612
PositionKinase
OrganismVenturia inaequalis (Apple scab fungus)
KingdomFungi
Lineage
Aromaticity0.07
Grand average of hydropathy-0.279
Instability index52.16
Isoelectric point4.97
Molecular weight174674.09
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21828
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.78|      10|      15|    1358|    1367|       1
---------------------------------------------------------------------------
 1358- 1367 (20.19/10.96)	TPVSTPQPGI
 1375- 1384 (18.59/ 9.34)	TPASTPSANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      13|      18|     587|     602|       2
---------------------------------------------------------------------------
  587-  602 (20.40/17.36)	PEPDlfsALEQAMGST
  608-  620 (27.08/14.05)	PEPD...APKQAPDQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.36|      15|      18|     515|     530|       3
---------------------------------------------------------------------------
  515-  530 (23.73/20.13)	DVdMDRD.DLFDAIDED
  536-  551 (23.63/13.93)	DI.IDADfDFFDEPDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     721.38|     231|     295|     809|    1064|       4
---------------------------------------------------------------------------
  809- 1064 (361.67/237.06)	PSSTIPPsalvrqPNESDGMFMLNP.TDlPVTLASTTA........LDGPLS..LSNK.DFILVAQIIAEQLIFSS..IDHSLQLTTEGQGMMDALPvKSYSITTARAaqTALK..SFHSGLTDCDFFK...FLcLSdHDRPQG.AKGQPQPQAKKVSPQAAEFSIATINALTTlppphvrvRRNEGLWDILPPAIPFWE......HLGLAPASGRKNLMAFCIYPGGQdvksQVCLFME...NLGASYESCKLGAHFRSdVQKSAPIQI.EQGLVPVTLTDQDES
 1097- 1357 (359.71/186.77)	PANEEPP......PIDNFIIYMVNPfTD.GRGIAELCAafwmlykaYSPPRSpqLDPRpDLVLQIIPIADVANPSTpvIHSSLYFQQMARRVYDRCP.PSRSFHDSDP..TPLRivSASSVLLESPIPKkigFL.LS.TDPPADlLNDQPHLHVAYAISENGEWVTAALTCLTG........RYQTTVSYCLAGGRPFWDvareiwSVALSVMRERRGAWRLCVVRVGR....MTCGELDawsSLHSSPAPFNIIVCIMS.IDPSPPVTIfPPASSPSTLPLIDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.26|      14|      16|     667|     680|       7
---------------------------------------------------------------------------
  667-  680 (23.62/17.35)	FKPSLVSEDTKYST
  686-  699 (22.64/16.28)	FSEKEIADLAKHST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.37|      20|      22|     330|     350|       8
---------------------------------------------------------------------------
  330-  350 (35.01/27.36)	SDTTLGTvFYWPRALC..FRTSP
  353-  374 (30.37/18.25)	SDGSQST.FEFEDQLEdpTKISP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.02|      24|     295|      76|     105|       9
---------------------------------------------------------------------------
   76-  105 (31.61/35.36)	WIFhgGSLTNGFAtrpDITKIAQDWpFQLK
  377-  400 (47.41/26.58)	WFY..SAKEGGFL...DSLQFAEDW.FGGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.56|      16|      20|    1445|    1464|      10
---------------------------------------------------------------------------
 1449- 1464 (30.68/22.01)	GFEGNGSGDVGSG..GGV
 1470- 1487 (26.88/ 9.13)	GLVGVHLIWVGQPprGGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.88|      34|     461|     246|     279|      11
---------------------------------------------------------------------------
  246-  279 (61.33/33.08)	EDSTFRPCYELDSYSDTLEPILLAPGGMPAVVND
  726-  759 (55.55/29.29)	ESSDTSDASDDDSLSDEIESLALASSPVKGIFFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      21|      21|    1503|    1523|      12
---------------------------------------------------------------------------
 1503- 1523 (38.67/24.41)	GAQ.QSQQGGQGFSPIDPSLPQ
 1526- 1547 (32.46/19.05)	GASiPANEAGQRATMTTTNQPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21828 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFFDEPDDDMLGAASSVPDVPTKAPPIHEPQVIPIAAIQPSHPPPEPDLFSALEQAMGSTNEVAVPEPDAPKQAPDQTPAAVKVEAIIMK
2) EKEIADLAKHSTARTETDIALPPRKRPRTRRRQPKDSDESSDTSDASDDDSLSDEIES
3) GMYPTPPDGVISQPGTVPASADAIPAIAAHDTPVPRTGLVGDGMDMDE
4) PLIDKSTPVSTPQPGISPDPHALTPASTPSANVDSAAADPANDKDAH
5) PRGGVQAQQAQQQQQQNQQGGAQQSQQGGQGFSPIDPSLPQTPGASIPANEAGQRATMTTTNQPQIHR
6) SPTSVRKKLFDETANDHTISRRRGSQYDPVPFKPSLVSE
543
688
447
1352
1483
636
632
745
494
1398
1550
674










Molecular Recognition Features






MoRF SequenceStartStop




1) DIIDADFDFF
2) RKKLF
536
641
545
645