<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21825

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMAIFNREQRPLKRPRIGPPDCYPQMTKQKEDDLSSDTLKNGFKNVELVEDEIGSAKPFVTVCNFSRLGSHFKAITEEKQRLNNVYDVNKKKNQVNLKDVYWPVTAKNRTNLNAWLQDLAINKSLKDLSKKIPTLNSNRKEEVFQLLSDNSVPLARSAWFIKLLSTGYNTSSDSKKKRPGGDLSHDWTQSLTKYLKDLLSKLSDHSHGQGKVTLSSDILSAYKQFLYNSQLADWLYQEGLLQRHSFLQWLIDTLDKVDFADSVSLTLLVPLTFKYIRDITASQSLARVLAGICTRYISYLYYHNNNNANEKESKPSSTNSTDNGTTEDWSLLAIYNDCQRHYPRLLLLTCILQIIAIFCPGALVYSIGAWNKGSSNDSLMHHGSPLDYLPGSICQLPGIELLEARVQKQMLAAMKASQSQIQLRSTLVENRWSSEKCKESDISVVVTQVLSVLEIHDKGAYARHNNGISVENLYTNIFPAIIKGSLVKDVLNNDEAIIMHLLEWAVTPFRYGFHRPILVAILLERRQGDLERMNENDAICNHLYYQELLLRFLDYYAILPSDDSELELEQSNASFKLLVALFAELIRRKVFSHDKYIMTLISRGDISTTSNSSRSYANSPDQIVGENDHDGESDECSHLGKKNEEENVIECGSPFSVRRDSEADISDQLKQQLSQQQEELQQLLESNETNSCNGNMDIMEYDNATDDVAFAKPEQENIANKTEGNLSDNDERGRDDDKDKNFNNVTTDTRKTFQHIAYVLHFPLPDIDLRNVDVGSHESRQRFTVLYGVGESRNLALQEVTEMWDEINICVDYLTTCDSQNSSSNDSNRINYASYLAPTIRKFKTLHIYSQYVLANTCANLIMENVIKENRYPSINKFNFVADLMEIAGDINGLLQFVIRLLSEGDSGAAETRSSLVLTIVAVFRRYYNCLLVSLKQATEAVEGLWRIVKHITNPASCSSADRCALACLADIFTHCSDLKLKNRAELESVLQKVKDSLPCSGLSKSNDPIDWKIFGEEFKEPRRICQAIRYDVMKKYNFVCNAILHVYHCGTYVRLLDIATLCAEVTSYSSGLNGEWMGVLRALCCSPSSNFGFTELLTQLEISDSRSADNIAMFTAVLISRHCFSLEELLRLVILPPLHDTRTSRSINQHFKIGAGARLSCHLLLRLLEKPSHEVNSYVDYNSGELVLKSWDRSLLSTWHHTLDLNYIYIVLKTMAAMVDSNKDNNSKDIFNFTTNMGILDEPDTTCANLALNVLKSICAQPLIQQHVLCNLRDCCSKEFLLDSMLTKRQAIYLQYLLCCADSITFDPSDIDTDINKEDVLNLLKDINQWSLRTTWLEIELHIKLCTRNEERTRIIDNLAEAIIKVYQTSNITKCASRSDMSAILSQEGNISLIAPFVAKLSNFAQGHILKAAGEVLERSKWWLPDDDNPCTLNQKPFLSLILTCLRCQDEHKRCFLSSIQKQFQQFLRSPIEERMPDNLKQREFLNDAIHLRLSLIGAVFDTILRDLTLCKDWIRLMLQFIASGTIDLFSEDKQLLSSILDMLSVLISTLNVSESVPSMSDEARKVNASLVKKFRKELDGINSPVVRECKKLFSLETPPVNVISVSSETDDTCYQNELFKTVAVDHSVHVNNWDILESTKFSSPTLWSYFAGVKVDRKPLTYENQFFSTMQHSHMIEESPVFYLPTKELEINPLPSAKPTTSKTVKNRTSNAKTAVPKEITPPSSVIKPEVKATKAAPGKRQRRRSTIKEKEEKRTTPSTITVTNTISKTTAADSMRDRQYLAIGSSSGTARSNATQNNEGFQSLISKQVKVSQPVSSYTISDRSQSETRAPRKNSGTQLRDLLGDMPTAMVYPEAPNVGRSQMQTTMVTSASDYSSFQSMNNNTIANINQGIDSSFSDTLNIASHSDNLSQRSLQQGMTSSLMDNNSMVDNQISTNFMSTRMPVNRSAGRMSQNLINSNSQQSRSNDVLRRLNKFNGHQSHYR
Length1986
PositionKinase
OrganismTrichoplax sp. H2
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index47.81
Isoelectric point6.27
Molecular weight224672.21
Publications
PubMed=30042472

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21825
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.17|      56|     312|    1042|    1104|       1
---------------------------------------------------------------------------
 1042- 1104 (95.60/77.29)	NAILHVYHCGTYVRlldiatlCAEVTSYSSGLNGEWMGVLRALCCSPSSNFGFTELLTQ....LEIS
 1362- 1421 (87.56/57.56)	EAIIKVYQTSNITK.......CASRSDMSAILSQEGNISLIAPFVAKLSNFAQGHILKAagevLERS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.16|      24|     938|      68|      95|       2
---------------------------------------------------------------------------
   68-   95 (38.07/32.01)	LGSHFKaiteEKQRLNNV..YDVNKKKNQV
 1015- 1040 (42.09/25.73)	FGEEFK....EPRRICQAirYDVMKKYNFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.45|      24|     938|     648|     700|       3
---------------------------------------------------------------------------
  663-  687 (36.02/68.26)	ADISDQLKQQlSQQQEELQQLLESN
 1906- 1929 (42.43/ 9.77)	ASHSDNLSQR.SLQQGMTSSLMDNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.65|      20|     312|    1301|    1337|       4
---------------------------------------------------------------------------
  140-  159 (35.02/ 9.50)	KEEVFQLLSDNSVPLARSAW
 1318- 1337 (36.63/ 7.42)	KEDVLNLLKDINQWSLRTTW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.32|      74|     122|    1658|    1744|       8
---------------------------------------------------------------------------
 1658- 1744 (110.91/93.02)	DRKPLTYENQffSTMQHSHMIEESPVFY.LPTKELEInplpsAKPTTSKTVKNRTSNAKTAVPKEITP.........PSSVIKPEvkatkaAP..GKRQ
 1780- 1865 (109.41/64.57)	DRQYLAIGSS..SGTARSNATQNNEGFQsLISKQVKV.....SQPVSSYTISDRSQSETRAPRKNSGTqlrdllgdmPTAMVYPE......APnvGRSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     265.91|      87|     388|     769|     868|      10
---------------------------------------------------------------------------
  769-  868 (124.66/127.35)	LRNVDVGSHESRQRftVLYGVGEsrnLALQ....EVTEMWDEiNICVDYLTTCDSQNSSSNDSNRINYASylapTIRKFKT.LHIYSQYvlANTCANLIMeNVIK
 1166- 1257 (141.25/99.30)	LRLLEKPSHEVNSY..VDYNSGE...LVLKswdrSLLSTWHH.TLDLNYIYIVLKTMAAMVDSNKDNNSK....DIFNFTTnMGILDEP..DTTCANLAL.NVLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21825 with Med12 domain of Kingdom Metazoa
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