<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21824

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDTNPIVNGSHGKQKIKLSTLMDFIIQKAYHDLNVLTEILPRKGDVERKIAIYRYSASMRQQFVRLLAIVKWATKAEKIEKCFQLCDFLEQEGKIFVDTADELYRIANEMLPQAKLPYFDLISAAEVLSRGSYSLLPTCIKDKIIPLPPMTRDDKKTTLQKLNEVIKDRLLRSNIPQGISKTVIGNGQLTLTVEGEFEVVLTLLGDDPALPWRLLSIKILIEEADIGAGKSLMHTLQIQYVQRLMQSRLFDSDEPLKDLYTSLHYLCLSLQLEVLHSQAENLVAHRWAGYVKLIDHLPGGKLILSYWRKKEIQDQLTLSEDRVDYTLTVYIDQEKNDTPLSVEHFPVQEELNTSLNKLDLKKRGGLSIETLLMEAIEKRSLSKLMEVKHALQSSGLNLPVKLERDRIPSLVVNLIDDDDSSERLLLSVDTKSGDTKAMFSSDLSLIDENVNVNKLCNIIADAKIEAHLRICLQALAPLPVTCNRRLPIHCDSFDLLDKISKHRLFVKLHDLDQYYLIIGVECSKDLNVKESFYLMNVNDSTLGNSSKDVAFHCASFIKIRDVKSCQISDSEYHLMNVTEGVKNSPSKKRKFEAAFGLSVGSIKHIKFARTRVVDMIHFTLSTVAHAQLCKGLQRANFLYEKIYKDIHGDNVLKILWPPKFPDLCSPIIMDSILKNLIDFRVRLVDDGFQWKWLAEVTFKNHPVTALKASKSIEEEHIRFIVSYDTNHKWNPSTGDISLKLLDDWKGIIILYRLTSDLAEALQDSSNCWKHYFLVYEFSPQCLTLLYGPKSKYIVRISWCDKMFKLRFSSISNANANFGENPHNLILDHLQHKLNNSKDIVKLLEILHGTFTPLKALLNVSKPRFSSGINPKLSTAALAFTVLPLSCDHLRIQFRHFFIMDVHLKNSNSVIIHDMGKNTEVAVIPGFKEFITKFIETVDTSMAFTNDISESNIMDTEDTYPNRPNSADNSHADATLAIEALKEMTSTVESPTLPFSTSPFISGHNSSPLFIFSTSDFIQADNSPSGRRIGENHSSPQASVPNQLAAIVSGNENQTFTGNYLNNPPTKLQKQEYWASLSKVSTLTSARSDSVEISQAAFAKLLEPVSTDESLSGCLLSPFERYLSCAFLLQQIKRSAKSCDVSVGNETSRIVNLRFSMDNMSAEAMIDVSHLPTLRLGLLSSRDNFMKEDDVRTLVEFFRLKVASYPYKAGSLSSFLTLITAPIKILEDCINIMKLELFPDPKRSWKVCWCLTIPPNCPKIAPLGFQAVALKAKLLIVLQFWKYGVTPLVIPIVCSVQDGSVNVLDSVYPDGVDSNLLSAVKSILKSRKDVYPSSRDRCQLFETVREILAKL
Length1350
PositionTail
OrganismTrichoplax sp. H2
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax.
Aromaticity0.08
Grand average of hydropathy-0.120
Instability index38.12
Isoelectric point7.35
Molecular weight152446.34
Publications
PubMed=30042472

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21824
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.54|      41|      61|     489|     534|       1
---------------------------------------------------------------------------
  489-  534 (62.15/53.75)	HCDSFDLLDKISKhrlfVKLHDlDQYYLII...GVE..CSKDLNVKESFYL
  552-  597 (61.39/38.37)	HCASFIKIRDVKS....CQISD.SEYHLMNvteGVKnsPSKKRKFEAAFGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.77|      57|      63|     933|     992|       2
---------------------------------------------------------------------------
  933-  992 (85.27/69.92)	FIETVDTSMAFTndISESNIMDTEDTYPNRPNSADNSHADATLAiEALKEMTSTVESPTL
  999- 1055 (97.50/67.94)	FISGHNSSPLFI..FSTSDFIQADNSPSGRRIGENHSSPQASVP.NQLAAIVSGNENQTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.96|      23|      23|     335|     357|       3
---------------------------------------------------------------------------
  335-  357 (39.01/24.24)	KNDTPLSVEHFPVQEELNTSLNK
  361-  383 (35.95/21.79)	KKRGGLSIETLLMEAIEKRSLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.52|      27|      63|       6|      32|       4
---------------------------------------------------------------------------
    6-   32 (48.12/33.01)	IVNGSHGKQKI.KLSTLMDFIIQ..KAYHD
   69-   98 (40.40/26.48)	IVKWATKAEKIeKCFQLCDFLEQegKIFVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.80|      21|      23|     733|     753|       5
---------------------------------------------------------------------------
  733-  753 (36.65/22.87)	TGDISLKLLDD...WKGIIILYRL
  754-  777 (33.15/19.98)	TSDLAEALQDSsncWKHYFLVYEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.29|      24|      59|     804|     829|       6
---------------------------------------------------------------------------
  804-  829 (39.63/36.03)	KLRFSS.....ISNANANFGENPhnLILDHL
  861-  889 (38.67/26.78)	KPRFSSginpkLSTAALAFTVLP..LSCDHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.27|      10|      23|     136|     145|       7
---------------------------------------------------------------------------
  136-  145 (18.23/11.42)	LPTCIKDKII
  162-  171 (16.04/ 9.11)	LNEVIKDRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21824 with Med14 domain of Kingdom Metazoa
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