<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21811

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSIGNEIEKWKEILKGLQDEFIHSDSDGSKIHPFAENNFNQIHANFKNSIANMKQHLDNILQMDNSSRILLLCQDKFQQQENCKYIKSYLRNIIESLGVHSSASDTDYIPYLEIIARSANLKFVHHGDNCFISSDMFYVEITLKNHKEVTEVKVVHGEDPKVTPVMTDLLRKRQFQEFKKHLLGLSSLYQLFGTSTEKSLAFMALQAVETDLSTLAAYQNLSGQNNPMEIINKGYVGHVTEREGGLPMKLTFYISPKDMFDNNTSEKINLEDAIIKGRAIGFSASVLIEQGKKCLLPKLPVVVLPTQVTDVPSYKKLCNENSAELPASFVLVFDDFIPVDASIMAKIYKIVKGQDKVYINSSSATIEDLLASNFREEKAKNGFHRNRNSSFVVKLPDQKQKYVFCKSLDSVPLGTLNVKRIPFLNPQQVPRIITLLRQQIVFNELISSCVCGQPNDLRDDEVGITTFEVITFPPNLLCLTFQHPLSDFLMSVEISVNENGTVSGRACVCPGDVSFCTDEYITRILQACLSIPVTLRAILRKSVSYSANQQGDSHDIAIPSSAGSTDAENQVMQFSNILSPTTSLSMKLTDAVEQNPTKRKRNDSEIEEANVNDFGQESAVRVVEAGTGSVTETKSASNDNNEIETPPTKVFIEDTDVMESPIVGETEYSKMSEMNDKPEDENNHEPEPVVENIVTSAIEEPADARVVSELEAFVHNTVHDSPSTLSKDPATYLQTVDLSNTTAESNSEPINDVSIPESDRDEIDRLPNPASIGEMDSDGNIMITSIDEVITGSILSVEDSMVATSDPGMEGADLLSAISDLAGSGSVNLEKSDDPSSLPSINDPTISKLLGLSREDETELDEEMIAGAEQNLLGLASYNSPEMDDSFAQIGSIIGEPDKELEEEENN
Length907
PositionMiddle
OrganismTrichoplax sp. H2
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax.
Aromaticity0.06
Grand average of hydropathy-0.336
Instability index48.73
Isoelectric point4.56
Molecular weight100181.22
Publications
PubMed=30042472

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21811
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.03|      38|      52|     462|     500|       1
---------------------------------------------------------------------------
  462-  500 (64.30/54.14)	VGITTFEVITFPPNlLCLTFQHPLSDFL.MSVEISVNENG
  513-  551 (61.72/46.60)	VSFCTDEYITRILQ.ACLSIPVTLRAILrKSVSYSANQQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.35|      29|      53|     811|     844|       2
---------------------------------------------------------------------------
  811-  844 (45.28/34.26)	GADllsaiSDLAGSGSVNLEKSDDP.SSLPS.INDP
  867-  897 (43.08/23.06)	GAE.....QNLLGLASYNSPEMDDSfAQIGSiIGEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.99|      20|      54|     592|     611|       3
---------------------------------------------------------------------------
  592-  611 (33.13/20.70)	VEQNPTKRKRNDSEIEEANV
  643-  662 (34.86/22.16)	IETPPTKVFIEDTDVMESPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21811 with Med1 domain of Kingdom Metazoa
Unable to open file!