Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSIGNEIEKWKEILKGLQDEFIHSDSDGSKIHPFAENNFNQIHANFKNSIANMKQHLDNILQMDNSSRILLLCQDKFQQQENCKYIKSYLRNIIESLGVHSSASDTDYIPYLEIIARSANLKFVHHGDNCFISSDMFYVEITLKNHKEVTEVKVVHGEDPKVTPVMTDLLRKRQFQEFKKHLLGLSSLYQLFGTSTEKSLAFMALQAVETDLSTLAAYQNLSGQNNPMEIINKGYVGHVTEREGGLPMKLTFYISPKDMFDNNTSEKINLEDAIIKGRAIGFSASVLIEQGKKCLLPKLPVVVLPTQVTDVPSYKKLCNENSAELPASFVLVFDDFIPVDASIMAKIYKIVKGQDKVYINSSSATIEDLLASNFREEKAKNGFHRNRNSSFVVKLPDQKQKYVFCKSLDSVPLGTLNVKRIPFLNPQQVPRIITLLRQQIVFNELISSCVCGQPNDLRDDEVGITTFEVITFPPNLLCLTFQHPLSDFLMSVEISVNENGTVSGRACVCPGDVSFCTDEYITRILQACLSIPVTLRAILRKSVSYSANQQGDSHDIAIPSSAGSTDAENQVMQFSNILSPTTSLSMKLTDAVEQNPTKRKRNDSEIEEANVNDFGQESAVRVVEAGTGSVTETKSASNDNNEIETPPTKVFIEDTDVMESPIVGETEYSKMSEMNDKPEDENNHEPEPVVENIVTSAIEEPADARVVSELEAFVHNTVHDSPSTLSKDPATYLQTVDLSNTTAESNSEPINDVSIPESDRDEIDRLPNPASIGEMDSDGNIMITSIDEVITGSILSVEDSMVATSDPGMEGADLLSAISDLAGSGSVNLEKSDDPSSLPSINDPTISKLLGLSREDETELDEEMIAGAEQNLLGLASYNSPEMDDSFAQIGSIIGEPDKELEEEENN |
Length | 907 |
Position | Middle |
Organism | Trichoplax sp. H2 |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.336 |
Instability index | 48.73 |
Isoelectric point | 4.56 |
Molecular weight | 100181.22 |
Publications | PubMed=30042472 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21811 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 126.03| 38| 52| 462| 500| 1 --------------------------------------------------------------------------- 462- 500 (64.30/54.14) VGITTFEVITFPPNlLCLTFQHPLSDFL.MSVEISVNENG 513- 551 (61.72/46.60) VSFCTDEYITRILQ.ACLSIPVTLRAILrKSVSYSANQQG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 88.35| 29| 53| 811| 844| 2 --------------------------------------------------------------------------- 811- 844 (45.28/34.26) GADllsaiSDLAGSGSVNLEKSDDP.SSLPS.INDP 867- 897 (43.08/23.06) GAE.....QNLLGLASYNSPEMDDSfAQIGSiIGEP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.99| 20| 54| 592| 611| 3 --------------------------------------------------------------------------- 592- 611 (33.13/20.70) VEQNPTKRKRNDSEIEEANV 643- 662 (34.86/22.16) IETPPTKVFIEDTDVMESPI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DSFAQIGSIIGEPDKELEEEENN 2) LPNPAS 3) MIAGAEQNLLGLASY 4) NEIEKWKEI 5) SKLLGLSRE | 885 766 864 5 847 | 907 771 878 13 855 |
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