<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21808

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMNGSNNYRQSQEDWHSSEFRQHVINQIMEAMRNSCNPTTKSAREMEAHIFGNADCKERYLNLVARLILHMKDNRKSDGPGTRRTSQTAPMLSQAFAQNQCNPTGNQTVPPVSRPNIQASVGGGANVNNPPALLTSALLSSSSNGPQPPTSISSQGQGLGYSQVSIASANAYCQQGQGTNQSQYPHQVQPNPSPCSQTVAFPNPSPYSQQPIMKSPHSSQPSQSPYALQQPIKSPHSNQSAQFAYVQQPIKSPHTQPQVGPSAYVQQQAIRSPHPSPQVNSGKGHHSQAHQQIIKSPLTTGHPANSYQQQQPSLKSPAHPQSVINNRSPYPAQNIKSPVQQPPMLNNRSPYPQPSIKSPYPQSQPQQQQSSKSPFYPQIVQAPTKSPLLAPSPVTNVTTPNSVTVSQSPATNANPGSVGSVGGSVPASSPLQSVNPSDDAAYMEKLRDLTKYIAPLRRLIDRTTKEGRKKEIHKMKSLLEILANPQKRVPLATLTKCESVLEKLQASFSPQSQPPSVAIGTTTNGIAATNTNGVTSIATTTSNSSSNTIVSTTSVGSAPVTTSSGLAPSQDVCKPLIDIIAANLNSPALAYALQQTCGPAFTTMRGPMTPLTEQTVKRKRIKYSDSKMRSEQENVIETEMTELDDLFVIEKNVHPLMDSESFLLKCSIDDASLPPVPSIYVIIPEDYPYSSAQCQTTTVEYRANPFFVTIIEDLSSRLLKMPRVTLTGILNAWKLSILKAYSKDEHEFENLHQQNSFIPESISSGLA
Length766
PositionTail
OrganismTrichoplax sp. H2
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax.
Aromaticity0.05
Grand average of hydropathy-0.595
Instability index69.67
Isoelectric point9.20
Molecular weight83056.20
Publications
PubMed=30042472

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21808
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.11|      17|      18|     201|     217|       1
---------------------------------------------------------------------------
  190-  211 (30.75/ 9.87)	NPSPCSqtvafPNPSPYS.QQPI
  212-  231 (26.36/ 7.37)	MKSPHS...sqPSQSPYAlQQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     130.76|      16|      18|     243|     258|       2
---------------------------------------------------------------------------
  243-  258 (34.78/15.11)	AYV.QQPIKSPH..TQPQV
  262-  278 (25.25/ 8.67)	AYVqQQAIRSPH..PSPQV
  287-  302 (21.66/ 6.24)	QAH.QQIIKSPL..TTGHP
  328-  343 (27.61/10.26)	PYP.AQNIKSPV..QQPPM
  349-  365 (21.46/ 6.11)	PYP.QPSIKSPYpqSQPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.54|      19|      20|     520|     538|       4
---------------------------------------------------------------------------
  520-  538 (30.46/19.96)	TTTNGIAATNTNGVTSIAT
  543-  561 (30.08/19.62)	SSSNTIVSTTSVGSAPVTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.68|      65|     159|     454|     518|       7
---------------------------------------------------------------------------
  454-  518 (109.49/57.90)	PLRRLIDRTTKEGR.KKEIHKMKS...............LLEILANPQKRV.PLA.TLTK.CESVLEKLQASFSPQSQPPSVAI
  562-  604 (37.21/15.10)	..........SSGL.APSQDVCKP...............LIDIIAANLNSP.ALAyALQQtCGPAFTTMR..............
  606-  678 (76.98/38.65)	PMTPLTEQTVKRKRiKYSDSKMRSeqenvietemtelddLFVI....EKNVhP....LMD.SESFL..LKCSIDDASLPPVPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      11|      41|     382|     392|       8
---------------------------------------------------------------------------
  382-  392 (21.25/ 8.43)	PTKSPLLAPSP
  425-  435 (20.90/ 8.18)	PASSPLQSVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.74|      26|      72|      25|      53|       9
---------------------------------------------------------------------------
   28-   53 (48.10/36.02)	MEAMRNSCNPTTK......SARE...MEAHIFGNA
   70-   95 (26.88/ 9.68)	MKDNRKSDGPGTR......RTSQtapMLSQAF...
   97-  124 (26.76/12.89)	....QNQCNPTGNqtvppvSRPN...IQASVGGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.55|      14|      56|     308|     322|      10
---------------------------------------------------------------------------
  308-  322 (24.75/15.12)	QQQPSlKSPAHPQSV
  366-  379 (28.79/13.73)	QQQSS.KSPFYPQIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21808 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MKDNRKSDGPGTRRTSQTAPMLSQAFAQNQCNPTGNQTVPPVSRPNIQASVGGGANVNNPPALLTSALLSSSSNGPQPPTSISSQGQGLG
2) NAYCQQGQGTNQSQYPHQVQPNPSPCSQTVAFPNPSPYSQQPIMKSPHSSQPSQSPYALQQPIKSPHSNQSAQFAYVQQPIKSPHTQPQVGPSAYVQQQAIRSPHPSPQVNSGKGHHSQAHQQIIKSPLTTGHPANSYQQQQPSLKSPAHPQSVINNRSPYPAQNIKSPVQQPPMLNNRSPYPQPSIKSPYPQSQPQQQQSSKSPFYPQIVQAPTKSPLLAPSPVTNVTTPNSVTVSQSPATNANPGSVGSVGGSVPASSPLQSVNPSDDAAYMEKLR
70
169
159
446










Molecular Recognition Features






MoRF SequenceStartStop




1) IIKSPL
2) PFYPQIV
292
373
297
379