<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21804

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMADVVFVVEATANLAEHFTQLKESYLLPAMEAVSFLLIIPSNSSTLSNIFHPTLFIAIMPMLNGILSPDIFLIFPPSFHSPIQYGLIAFSTLHNSPESTILSWKPPTNNLNVCKQWLDSLSQISQRNGENEATQAQSPIQYGLIAFSTLHNSPESTILSWKPPTNNLNVCKQWLDSLRFNGGGVEEYSAIEDGLGVALQCFDDMQAKYHKENGTIRDKFCILVCNSSPCGIPSSACYQYCGYSCERIAELIGSRKVNLSVISPRRISTLCKLYDKSIIEDLHVMPSQDYATSPHHLVLLKGFKLATKERSEPKTTVEPKPQPVVTNGTKEHRTVNDATANTRNFIPPSTSINSPPKNTPVVVTAASETIMPPVRSSVTNAVPMVAPVSLVTPPQTAFNPTPRDIPPVKVANRDKPNSNEAIPEIRKDNISRSYPHTNPSTTKASLEITNRFPNTNPTVPPNVRHPQPNLNVQRHLIWSGLLSWERHNNKVDRRSGETLSVNGYAYSNENIRGEDWPRQLILRFVPGNLLAEMMPLLRKSIQILFHISMTDNNTKNLIQTLTQNKVVAFISFQGISLNPEEKLRLLILTYNPKKNFTGYIPRDQMDFVQKFQVVMKKSRETQKQKQQMQSGGYPPHSVGQPQMYVNQQQQQPQPQPQQSLLQSHSMKTPVGAQQLSSLSTSQSGPITSTKNSMVNMTRSSNFELGANSLGKLQHLTSLDSQSKDLVKNYESRSQVSSIESILQQQPDVLSRFQHLNQQRQGNTMQQQQQSQVRNFLNQQQQSNVTQPPQQQLLNQQQQQQQQRQSMSHQHNWALQQRLQRMQSAQNQSQQLANTLNSAQNRAPSEDWYP
Length848
PositionUnknown
OrganismTrichoplax sp. H2
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax> unclassified Trichoplax.
Aromaticity0.06
Grand average of hydropathy-0.569
Instability index59.88
Isoelectric point9.28
Molecular weight95400.88
Publications
PubMed=30042472

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21804
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.01|      37|      56|      79|     128|       1
---------------------------------------------------------------------------
   79-  115 (82.79/37.57)	HSPIQYGLIAFSTLHNSPESTILSWKPPTNNLNVCKQ
  136-  172 (82.22/54.82)	QSPIQYGLIAFSTLHNSPESTILSWKPPTNNLNVCKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     221.58|      37|      37|     733|     769|       2
---------------------------------------------------------------------------
  599-  627 (29.17/ 8.91)	.......IP..RDQM.....................DFVQ..KFQVvM...KKSRE..TQKQKQ...QM
  628-  662 (50.46/20.53)	QSGGYPPHS..VGQP.....................QM.......Y.V...NQQQQQPQPQPQQsllQS
  673-  732 (30.28/ 9.51)	QLSSL.STS..QSGPitstknsmvnmtrssnfelgaNSLG..KLQH.LtslDSQSKDLVKNYES...RS
  733-  769 (68.06/30.13)	QVSSIESIL..QQQP.....................DVLS..RFQH.L...NQQRQGNTMQQQQ...QS
  770-  804 (43.59/16.78)	QV...RNFLnqQQQS.....................NVTQppQQQL.L...NQQQQ...QQQQR...QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.64|      36|      36|     312|     347|       3
---------------------------------------------------------------------------
  331-  367 (48.27/19.11)	H..RTVNDATANTRNFIP..P.....STSINspPKNTPVVVTAASE
  368-  403 (38.78/14.11)	TimPPVRSSVTNA...VPmvA....PVSLVT..P.PQTAFNPTPRD
  407-  446 (47.60/18.76)	V..KVANRDKPNSNEAIP..EirkdNISRSY..PHTNPSTTKASLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.74|      12|      33|     227|     239|       4
---------------------------------------------------------------------------
  227-  239 (21.36/18.40)	SPCGIpSSACYQY
  262-  273 (23.38/13.86)	SPRRI.STLCKLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.25|       9|      56|     116|     128|       5
---------------------------------------------------------------------------
  116-  128 (14.21/16.51)	WLDSLsqisQRNG
  173-  181 (20.04/10.74)	WLDSL....RFNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.89|      16|      34|      26|      41|       6
---------------------------------------------------------------------------
   26-   41 (26.98/14.53)	LLPAMEAV....SFLLIIPS
   58-   77 (24.91/12.94)	IMPMLNGIlspdIFLIFPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.03|       9|      21|     463|     474|       7
---------------------------------------------------------------------------
  463-  474 (12.64/12.40)	RHpqpNLNVQRH
  485-  493 (17.39/ 6.66)	RH...NNKVDRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.89|      15|      22|     185|     200|       8
---------------------------------------------------------------------------
  185-  200 (22.01/21.98)	EEYSAIEDGLGVaLQC
  210-  224 (27.87/21.94)	KENGTIRDKFCI.LVC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21804 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERSEPKTTVEPKPQPVVTNGTKEHRTVNDATANTRNFIPPSTSINSPPKNTPVVVTAASETIMPPVRSSVTNAVPMVAPVSLVTPPQTAFNPTPRDIPPVKVANRDKPNSNEAIPEIRKDNISRSYPHTNPSTTKASLEITNRFPNTNPTVPPNVRHPQPNL
2) PDVLSRFQHLNQQRQGNTMQQQQQSQVRNFLNQQQQSNVTQPPQQQLLNQQQQQQQQRQSMSHQHNWALQQRLQRMQSAQNQSQQLANTLNSAQNRAPSEDWYP
3) SRETQKQKQQMQSGGYPPHSVGQPQMYVNQQQQQPQPQPQQSLLQSHSMKTPVGAQQLSSLSTSQSGPITSTKNSMVNMTRSSNFELGANSLGKLQHLTSLDSQSKDLVKNYESRS
308
745
617
469
848
732










Molecular Recognition Features






MoRF SequenceStartStop




NANANA