<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21798

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSLAELTRNCFQSGISASKWLSLCKLLISKESSISRVPDDIEINLSNSVLVLYRSYPGDPDLQEYLKAAIQDGTLSVATFVATLLQAARSPELHTAATLDTLCRIALDAHYSSGLPPIGSVVRYEESPITILGTVQDALALLRTAHSLPMTHFHQLTTSAAELVILLLSCVSDISQVSTAQAMVHFADANDLLHNFRLAPDVRQVLETFVLSLSFLIGDDAKAAREAQIMHSIQLALGKGDIHGSGSDTDITTFSLMLHRLVSYRAEAFGSGDGPGTVALLMTLFRWASWSPTVFYTQAFLSALTCMEQGSSNALVWKAFVVGRLPHLLAHFESSVNADGVGNSDWRRATQAALTAVSRHSELISHCDNIITRTKTFNAMQDEDVTPSIFRDLLRTMVRTELVGLSFAVELDPSVSSEDTHRLRGEAQDAGVDFEVYLESKIMPDIAIEDLRSFLDRLWMDVGSHHDFANVAIRRFISLANAYDVEGLSHFCKLFFTFEPILEIMALHTKVSDLLCRALLLLDQYDCETVGDPQTAVSHLGDVVLFLQYTTSRFRIDKVPFAPENRSLSSQFLHMTDATHAAERLSGEDGPAFNAWFKALFDSSSEGIEDSILRSTQPKVLLRISATLFSQAIRACLVQKIDRDVLNNGVSYFTGPLLNWTLVGVIKGLVREIQQRGLSAPTHLEILQTLLLSPACPRPVLSLCGPQVLLLFSDKTAKAKLSGIDITSVRRVVNQALNRSTEGNISEIRPAVSWIPREEEPKRAIQVVLALARAGKAPSFDVERCIKIMPPTKFLQLLWSELVISASLGEMDICRRIATFVLTTPRSSSMPPLLPIFLHIISPSLIFAIDHQQPPEHTMNVELLVTVVSSALTAALHLELAMHSVTGDHGFMLGQPSSGMARRFATELRSRQNNRTSRAIAQRLASSQSFVANFPVFMSELG
Length942
PositionTail
OrganismHypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Hypsizygus.
Aromaticity0.07
Grand average of hydropathy0.136
Instability index48.69
Isoelectric point5.90
Molecular weight103645.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21798
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.40|      11|     412|      93|     104|       3
---------------------------------------------------------------------------
   93-  104 (17.10/13.62)	LHTAATlDTLCR
  507-  517 (21.30/12.08)	LHTKVS.DLLCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.32|      24|     213|     246|     269|       4
---------------------------------------------------------------------------
  246-  269 (40.07/28.03)	GSDTDITTFSLMLHRLVSYRAEAF
  272-  295 (44.25/31.81)	GDGPGTVALLMTLFRWASWSPTVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.38|      50|     717|     105|     172|       6
---------------------------------------------------------------------------
  105-  172 (76.50/75.25)	IA...LDAHYSSGLPPIGSVVRYEESPitilgtvqdalallrtahSLPMTHFHQLTTSAAELVILLLSCVS
  817-  869 (83.88/51.03)	IAtfvLTTPRSSSMPPLLPIFLHIISP..................SLIFAIDHQQPPEHTMNVELLVTVVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      12|     345|     442|     459|       9
---------------------------------------------------------------------------
  442-  459 (19.03/21.73)	IMPDiaiedlRSFLDRLW
  788-  799 (25.48/13.78)	IMPP......TKFLQLLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21798 with Med5 domain of Kingdom Fungi
Unable to open file!