<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21792

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMLGRKDDKSPQALPLYKSHPPDWLPKVHASADLGYPGFFPPRAGQDEDVLSEANVKNGFVLGHQVSAETFSAQSIINEDLRSDATISSLEALMNAVFIRRADSIPPVPSSTFRIPSRVTLNDAKRQAWFADLANPGVPLHKLGKSVPHGAKGHDLLDLLQSNNIAIPRAVWFLRVFGANETAGLRNKPSYNPVQYSVDWANVVTSYMKKQLADIALPSAPRPGLNIKQTFKGVLADSDTRERWISRFTYCLKLLRTFYSEGLVDNRTFLIWIVQQMGICNLAQTGFITRLADEYLDGIIGSRPLTRPFIDASLSKLSEIHTSSAQEFLCDTQRLLKTLLKRLCIASPDSFISPRMWKAYSSLLEEILRENVMDQSAYLHIEQHSRNVSQALHDHFTDIQRRNEALLFQRIPIESSTRLGSAVSDVKLLNSISSTTDMNTMVFFPQLTDDKTRFTEKLDMLLTWCVTPLQYGDHRPFAAVTLIRNWRTLAGDRANRRDFSPPDEFLQDRLFDWLDSSESAGEPENIRAVALLFGKLVKHELFSYASYIQRLIARGEQGLSFTSDTESRHRNFLRWIPLFQSTSSLISQRKAALYGVRARETPEDINEREIRREIRSVLPDVFGGESHIPVSSTSMLLSTCKTLVSSTRFEQVRTFRQWLLPILQKHIAGQGTAITSPMLLTTYSISVELMSHAKCFHTILDLTLSLLEHSITIDLLIAVIDTLHRFAVIWASMNAMGQIIFALDTAHQSWKARGIQSRPLLSLLLEFDNGRYLSMASRDRITTDITAFISALQPPTDIPDSVPDVLPEILLLAGDPDVDAPTLLANSLWIKYRKSSDWAWKVWDNTVASLRQIPLMTSDTSGRRACALRYGAFLWHVDQHLAMGLDNEVLQWFVGPGKNEVAALSSDAWEVLIVVMLYMSIHGALKTTTILRGLVYPAWLQAANIATVQPGPGIETLLRSANGLCRRLLLLEDINDDNLPPENIFELQCIRTRRQDVYCMPHFPFLASSIPLLICVENNEHVPEDLRADSTLLRQMICQNRDFRQGAYRNLDAIREAFEYSLQQLEQPAGPLGKHIVAGLRMILCDISDDIELSDWPSSTCLLGPWKIAATMVQLQLILKQMGQGLMQNANDRATNANLDKLILMLFHHSMTTEEAFYVGEMARGVDSVVAGKFISNGLKSIKDMMLQESSSSADVTLTPECFRRSSDLLRVLTYVAEPLREKPGTLPILEHAIQDDLLDILYSKIVSLESSTTETATPPHLMTSKEIVLLLRLLQFELGFRSTWTSKTKEINDKLACSLFKLAQFYGASENLDPIIYPLIIDTLYYIYDEIPTDPKATYDPFRNYPDIPISDLPFNLPSEYRKQLASLLPLLPVTATVLNLVNSHRDAEGKIVVGTSVVNRPWEWIENLGDPAIIDPKDDQRERETEKSRMKYQVKNSGSLSLETFGARITGDGVLRDSGQELDSRTEQNLRCFEDGLSAENIFKRDWRETRVELEDDLGSSGAGPKGEIFHDGGGTSFRSGVSRLEKRPTQRASPTSSVVSRISARGSAWQSPGQRPNSRQSNSTISDTIDVDSVTTGSSARRLPASKRKATSIAISDDEIEIIEGPVPVRPNAAKKVKAKAPAKARAKKK
Length1632
PositionKinase
OrganismHypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Hypsizygus.
Aromaticity0.08
Grand average of hydropathy-0.216
Instability index49.01
Isoelectric point6.36
Molecular weight182958.90
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21792
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.41|      43|      98|    1055|    1104|       1
---------------------------------------------------------------------------
 1055- 1104 (65.09/60.57)	EAFeYsLQQLEQPAGPL..GKHIVAGLRMIlcdisDDIELSDWPSST.CLLGP
 1154- 1199 (65.31/40.17)	EAF.Y.VGEMARGVDSVvaGKFISNGLKSI.....KDMMLQESSSSAdVTLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.04|      58|      98|    1449|    1506|       2
---------------------------------------------------------------------------
 1449- 1506 (99.53/58.32)	RITGDG.VLRDSGQELDSRTEQ.......NLRCFEDGLSAENIFKRDWRETRVELEDDLGSSGAGP
 1543- 1608 (86.50/49.70)	RISARGsAWQSPGQRPNSRQSNstisdtiDVDSVTTGSSARRLPASKRKATSIAISDDEIEIIEGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.53|      24|     100|      10|      40|       3
---------------------------------------------------------------------------
   10-   40 (38.61/41.99)	PQALPLYKSHPPDWLpkvhasADLGYPGfFP
  115-  138 (44.92/27.50)	PSRVTLNDAKRQAWF......ADLANPG.VP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.96|      53|     292|     519|     574|       9
---------------------------------------------------------------------------
  519-  574 (86.50/65.35)	AGEPENIRAVALLFGKL.VKHELFSYA....syiQRLIARGEQGLSFTSDTESRHRNFLRW
  667-  692 (27.73/11.92)	AGQGTAITSPMLLTTYS.ISVELMSHA..................................
  812-  869 (73.73/47.43)	AGDP.DVDAPTLLANSLwIKYRKSS..dwawkvwDNTVASLRQIPLMTSDTSGRRACALRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21792 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELEDDLGSSGAGPKGEIFHDGGGTSFRSGVSRLEKRPTQRASPTSSVVSRISARGSAWQSPGQRPNSRQSNSTISDTIDVDSVTTGSSARRLPASKRKATSIAISDDEIEIIEGPVPVRPNAAKKVKAKAPAKARAKKK
1494
1632










Molecular Recognition Features






MoRF SequenceStartStop




1) IAISDDEIEIIEGPVPVRPNAAKKVKAKAPAKARAKKK
1595
1632