<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21787

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSNVQDDVVGTFGVSTLNDNSATTDTLGQSEPTIEELERELPTVYDGQIPLGDLLSRVVQSIYAELAELAETMPNMSDSARKRTLADWVVKTKKQVVKLYAVAKWARDAETVQKCMNITAFLMTQNQQFEGAMEGLKYARESLDPARLRNHDLLTSLDVLTTGSYLRLPTCIKKAIIPVVPLSDDEVSKTLSDMEDIIRYRLRVSELIPVEMSRFRIADGRVSFTVPKMFETSLCLRGAERDDGWFFVHVEFLISVGGDLTGLQEFPRIPTGIMKRHITDEADARLAYYLPIPEDAHPPGVEIPSRPQLPQGVFDAPLVRVYNFLQMMSLSYQLEILWYQAARMRSLGWADYLTVQMSPDRKMMTVSYWIRSAPPQLQGRSRLKLPSLGGTVTISIVETSGPARTPKSRAFARIQHKSKFGNATPSDEVEGLRFQTRWEPAKGALGVNLPVTDSTIPDDALHVDADNLDFESLLRSVIERHARSILKIFQLQLQHGPTRTVFSPPGVVTLVGDALRVHLCADEVVIITIDSRTGRMNLRDTGDLAAAGRGPRFTAISERLNENPTILFDALNRLRHHTITDLAEQKANYLGLQSFRRRNFQNEEMIKLGPSARGTLYIQLSNFPNHYLVLVITDERFRYALITTRVLSESMFSHMVMEDIAWLDFDRIHGEDVVITAYTGRSDVRIGKRKRDSDDAFGREIGMEPDSGFNLETQVLRELYSYCCARVAYMNVERQFKLRGIPFTHVNPTKNTPVTMEMAHIQSSLARSVPALCVQSEHILSGAPAAEAAMPNIRVIPLNWWSEKNAQVATCVKLKYVQQPMGKTAGTSTVIRPSKRIIYDTTQAVVSFLSENVNTCVDEFLEEWARVSKMVVIAREVGQMAKEGTWQDVRLLSFDLQTVEFVYALDYTVSISCEDQLSPMGGNFDLRFSRCRTGLGSSENHDRFNPHDDAEPFLRNILRHGHGRLAPSLHRLVALLRDTLPIVRELEEIRLKGDTEGRTVDTFAKAAGWYRLLYGDLRHALDFRLMSDQRVAILDASHSLFDSTASGSFDALSHDKVDDVLGLRPIPRFAEIVMEVVRDAISHGTLQPGKVAVVDVGIVCDTSTVSELGRAIHTKVMQRFPNQS
Length1125
PositionTail
OrganismHypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Hypsizygus.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index44.44
Isoelectric point6.13
Molecular weight126407.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21787
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.99|      61|     335|     127|     198|       1
---------------------------------------------------------------------------
  127-  190 (94.46/70.09)	NQQFEGAMEGL..KYARESL..DPARLR.NH....DLLTSLDVLT.TGSYLRLPTCIKKAIIPVVplsDDEVSK
  468-  536 (76.67/47.07)	NLDFESLLRSVieRHARSIL..KIFQLQlQHgptrTVFSPPGVVTlVGDALRVHLCADEVVIITI...DSRTGR
  551-  593 (47.87/35.14)	GPRFTAISERL..NENPTILfdALNRLR.HH....T.ITDLAE.Q.KANYLGL.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.03|      55|     199|     839|     900|       2
---------------------------------------------------------------------------
  839-  900 (79.55/71.11)	IYDTTqAVVSF..LSENvntCVDEF..LEEWARVSKMVV.IAREVgqmAKEGTWQDVRLLSFDLQTV
 1041- 1100 (79.48/50.62)	LFDST.ASGSFdaLSHD...KVDDVlgLRPIPRFAEIVMeVVRDA...ISHGTLQPGKVAVVDVGIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.83|      73|     247|      42|     123|       3
---------------------------------------------------------------------------
   42-  123 (106.77/105.82)	LPTVYDGQIPLGDLLSR..VVQSIY.AELAELAETMPNMSDSARKRTLadWVvktkkQVVKLYAVAkWArDAETVQ.....KCMNITAFL
  291-  371 (120.06/88.63)	LPIPEDAHPPGVEIPSRpqLPQGVFdAPLVRVYNFLQMMSLSYQLEIL..WY.....QAARMRSLG.WA.DYLTVQmspdrKMMTVSYWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.17|      18|     207|     402|     423|       5
---------------------------------------------------------------------------
  375-  392 (31.91/12.42)	P...PQLQGRSRLKLPSLGGT
  403-  423 (27.27/17.09)	PartPKSRAFARIQHKSKFGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21787 with Med14 domain of Kingdom Fungi
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