<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21781

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASKLHAAHSMPSSAPPQISLADQLLSSRIPLPHDPYVSFVVFIPTTSSTIRPHENIELARRSILSRNASATLLDSFLFSIHIGTNSCLYVFRVSCKEDVADAASKLASLSFDGLTGTETSSFALQDLYPCSPSCSLLSQPCPSCINGASSRVTSSPASLLPRKPLRNVYSHFLEAVRLRLLSDVADASTTAGTQRSVKRLKGGFLLGSQPSTSEWGASWEYRVLSRPLLYCQLQIHFSMPHLIIHPLLHQTPFLPLSYSLPLPQGTPIMLLPHGTPAYFLTHYAGPTSALTKQFQESLQGMGVSGWDNPLTAPKPEYIIAWLNVENKQGEDKGIICIYPTALCLSFVPSFSSISEYGSRTPLDYIPELPAPLQPSPQMTAAHAHAPSHAGIGVSQPTSPSPSATIFSVPVSIHTPTPGPASATPTTASFPRNTSPHPSFPPLTSLPIRSPNPILPLTPTTATLRAFRTLTLSHSKDIRGVATEVGGYVDAVVRERERERERLRREREAGTSASASASGSGIGSASGMGSAGVRTPATAMPTPATTITTEAPTPLPMAGPVAGPSQHTTPTSAQTASQNFYPSPPQTNPPIVSAHVPVRGGVALPTPSTTGTTPSVSASAPDTTNLPVPIAPHPPNAVASTSHAAGAGVGYDAWSMPTQQQYLNMGMDIDMDMNFDMDIGMDMNMNLGMGMGMDFGDSSGDGGRGGPGGGDASMGGLGMGMGFDADEGDAAFTDDDFSFFDRPSAAAPAPTIGAVRGVVNSGRGNARGDTRTGREGMFVNLSGPGPPPAPPPAIPSSSQAPISFTQLHGNLSESQLGQHVSSSSWVATAGAGPDSFTGGLIPGFDYPGDGNTNQNNPYTNTNTTTIVTHSSTHQSTHPRTNIHLSLLPPSPGPTPRSTSSVSVPGTPTVAVHLESSLEPSSASIPDRRSIFDPIPFAPYHRVLDGKYAVGKFSLPSPPEEPSDMDHDRSDARPELPLGTGRGLAKGFELRNEKRTGSEIGKGWRSKYMAATDPRIGVVRKLIGVKRKNASEHGGRDAAVIIGGVPGPNLMPRPKLYSPSSWIREHEDWEKNGAGEEQKKGAEERLGVMKAGEQVLKLEADEDDDEDAESDEDMLEDDESPVISRPSTPLPAYLPLGPTLLHTQFQHSELLPLSTPLRPPGSAVAPTNMITATLIASVPTPVSPAAMLGATSEKSKSLEAAAFTVATEVVENPPWAEAWRASSVRGCLTGQKIETRLADVRTVARLLADVHGLEAPLDVGTLFGFRNASSTAGGEAASSKVKPLQLQEAPLFAIGKGDSVVHLLPTAARFWEKLALGPRAGKKNGVSFVLYEDDGEQRQVQVEAWLGLVTAAYEGKHFGTLVPGKSTCCPRDGIFPLRFDSSFRKTLASFIASLPASQSSLIFFIVTPMAIMSFASPVLRQVFSAIKKAAKTYSEAQIHFQFVPEQLVRGSLGNPSTDFSDLEVLCASVYNRILLPVDRVMSRRFFEHGERVRSYFEEPMTTLARPEYSKVTFTRAGHAPLDVVDRATFVHVGYGVSGGGRWLVAACIDQRGEGHDLGVWMIGGGTGAGDGEVDVEADAEAEGGGEMVFIVRKVWEFVVQFARKADVEWRVVIAKLGYMGGGELDAWASFLDANVATSHDLRVVNVTVLSVEPEAPWTFCTTSAASPTAPSALSRPNLKPSPTKPPSHPARSASTSKLNNHHHPQNIFTDVTTMIYTLAPYTHLPQSLPPSLGDLGIALSYICEPPANVDAPTASISALAMASEQDRFPHPLSLRPRSSTALICIPASSPSPTAIAMIGVHLLHISTPRTPHPTHAHSEADVPALHMEITRNFYELGVLAGLRYRMGNGTWNAGGMAGGDGNAGLPFHLAAVRTMARVVACAGEQEGSIGEG
Length1891
PositionKinase
OrganismHypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Hypsizygus.
Aromaticity0.07
Grand average of hydropathy-0.193
Instability index47.05
Isoelectric point6.08
Molecular weight200508.07
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21781
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.78|      26|      27|     676|     701|       1
---------------------------------------------------------------------------
  649-  678 (31.77/15.69)	VGYDawsmptqqqyLNMGMDIDMDMNF..........DMD
  679-  707 (47.11/26.92)	IGMD..........MNMNLGMGMGMDFGDSSGD.ggrGGP
  708-  736 (43.90/24.57)	GGGD..........ASMG.GLGMGMGFDADEGDaaftDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     424.29|      90|     122|    1612|    1701|       2
---------------------------------------------------------------------------
  361-  431 (49.84/13.89)	..............................................TPLDYIPELPAPL.Q.PSpqmtaahahapshagigvsqpTSPSPSA.TIFSVP.VSIH..TP.TP.GPASAtPTTASFP...
  841-  926 (101.46/36.41)	IPGFDYP..GDGNTNQNNPYTNTNTTTivthssthqsTHPRTNIHLSLLPPSP.GPTPR.S.TS.....................SVSVPGTPT......VAVHleSSLEPS.SASI.PD........
 1612- 1701 (149.95/57.58)	IAKLGYM..GGGELDAWASFLDANVAT..........SHDLRVVNVTVLSVEPEAPWTF.C.TT.....................SAASPTAPSALSRPNLKPS..PTKPPSHPARS.ASTSKLNNHH
 1736- 1825 (123.05/45.84)	IA.LSYIcePPANVDAPTASISALAMA..........SEQDRFPH..PLSLRPRSSTALiCiPA.....................SSPSPTAIAMIGVHLLHIS..TPRTP.HPTHA.HSEADVPALH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.62|      48|      68|     529|     576|       3
---------------------------------------------------------------------------
  253-  315 (63.72/22.86)	PFLPLSYSLPLPqgtpimlLPHGTPAYFLTHYAGPTSALTK......qfqeslqgmGVSGWDN.PL...TA.PK
  543-  606 (70.11/25.94)	PATTITTEAPTP.......LPMAGPVAGPSQHTTPTSAQTAsqnfypsppqtnppiVSAHVPVrGG...VALPT
 1150- 1179 (30.79/ 6.99)	...................LPLSTPLRPPGSAVAPTNMITA.........................tliASVPT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.77|      20|     124|     614|     641|       4
---------------------------------------------------------------------------
  435-  454 (41.38/11.76)	SPHPSFPPLTSLPI....RSPNPI
  615-  638 (31.40/26.14)	SVSASAPDTTNLPVpiapHPPNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.67|      64|     124|    1216|    1283|       5
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  181-  225 (37.90/13.64)	LLSDV..ADASTTAGTQRsvkrlkgGFLLGSQPSTSEwGASWEYRVL...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1218- 1244 (28.94/10.33)	...............................................srpllycqlqihfsmphliihpllhqtpflplsyslplpqgtpimllphgtpayflthyagptsaltkqfqeslqgmgvsgwdnpltapkpeyiiawlnvenkqgedkgiiciyptalclsfvpsfssiseygsrtpldyipelpaplqpspqmtaahahapshagigvsqptspspsatifsvpvsihtptpgpasatpttasfprntsphpsfppltslpirspnpilpltpttatlrafrtltlshskdirgvatevggyvdavvrererererlrrereagtsasasasgsgigsasgmgsagvrtpatamptpattitteaptplpmagpvagpsqhttptsaqtasqnfypsppqtnppivsahvpvrggvalptpsttgttpsvsasapdttnlpvpiaphppnavastshaagagvgydawsmptqqqylnmgmdidmdmnfdmdigmdmnmnlgmgmgmdfgdssgdggrggpgggdasmgglgmgmgfdadegdaaftdddfsffdrpsaaapaptigavrgvvnsgrgnargdtrtgregmfvnlsgpgpppapppaipsssqapisftqlhgnlsesqlgqhvsssswvatagagpdsftgglipgfdypgdgntnqnnpytntntttivthssthqsthprtnihlsllppspgptprstssvsvpgtptvavhlesslepssasipdrrsifdpipfapyhrvldgkyavgkfslpsppeepsdmdhdrsdarpelplgtgrglakgfelrnekrtgseigkgwrskymaatdprigvvrkligvkrknasehggrdaaviiggvpgpnlmprpklyspsswirehedwekngageeqkkgaeerlgvmkageqvlkleadedddedaesdedmleddespvisrpstplpaylplgptllhtqfqhsellplstplrppgsavaptnmitatliasvptpvspaamlgatseksksleaaaftvatevvenppwaeaWRASSVRGCLTGQKIETRLADVRTVAR
 1245- 1283 (42.24/21.51)	LLADVhgLEAPLDVGTLF.......GFRNASSTAGGE.AASSKVKPL...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1850- 1876 (32.59/10.17)	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................qlqeaplfaigkgdsvvhllptaarfweklalgpragkkngvsfvlyeddgeqrqvqveawlglvtaayegkhfgtlvpgkstccprdgifplrfdssfrktlasfiaslpasqssliffivtpmaimsfaspvlrqvfsaikkaaktyseaqihfqfvpeqlvrgslgnpstdfsdlevlcasvynrillpvdrvmsrrffehgervrsyfeepmttlarpeyskvtftraghapldvvdratfvhvgygvsgggrwlvaacidqrgeghdlgvwmigggtgagdgevdveadaeaegggemvfivrkvwefvvqfarkadvewrvviaklgymgggeldawasfldanvatshdlrvvnvtvlsvepeapwtfcttsaasptapsalsrpnlkpsptkppshparsastsklnnhhhpqniftdvttmiytlapythlpqslppslgdlgialsyiceppanvdaptasisalamaseqdrfphplslrprsstalicipasspsptaiamigvhllhistprtphpthahseadvpalhmeitrnfyelgvlaglryrmgngtWNAGGMAGGDGNAGLPFHLAAVRTMAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.54|      14|      15|    1539|    1553|       7
---------------------------------------------------------------------------
 1539- 1553 (22.70/19.48)	GRWLVAACIDQrGEG
 1557- 1570 (27.84/18.35)	GVWMIGGGTGA.GDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.52|      13|     130|     380|     393|      13
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  380-  393 (21.08/15.16)	TAAHAHApSHAGIG
  511-  523 (23.44/11.20)	TSASASA.SGSGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.38|      13|     591|    1125|    1139|      15
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 1125- 1139 (22.61/15.61)	PSTPLPAYLPlgPTL
 1719- 1731 (27.77/12.98)	PYTHLPQSLP..PSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21781 with Med13 domain of Kingdom Fungi
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