<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21779

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTTDKMPLMLDTAMSVDLQDVDDLFGDDVGLPISLRPQGKQLLARLDELRSRGCCSYVTLLTTPAAITDDAAIRSVAWSRSGTIASLTPDGQTLQLRFLSCQPENGSWELSEPTTCEAIKGTPAIPLVHLEWSGTANPDLAVVDATGRVAIAGFPISLNQPFVTRKWDTDVVDDSHAVVGSYWLPVTPSSQQKQPYNIIHGPAKRHGNTYQYETSFLHAGGPSHPHSSKSALLCVTMGGMLKMYWSQNNNRTEETLLELESVNSSDELVTHAALASDKKFLLVALATSSFALKLLRLDLRWAGLAGPSDKAALPQNNRLSPTLEETHLAYASWLYSGPNDANHDPSVAALSYLHVLPSILDNTGKNTVPPVIVTIRSRAATEGSFETALSILDRWEAVDERQAVPAAFEQLGNRRHSVSSDLPNLTRLRKLEPIIINKVVIGFQTIQFGKILLITMSDGTVEYRDRYSFEEVFNTEDLTRVMNLRQVGWTFADNVPCQQVAFSPTQCSMMLLADDGKLRWSKLQHPVVDAANYVPDVRYVATVAALAVTAASSIWYQSNYDDLLAVVHPMTMRKRFTQEWVSELIRILKIQIDYTEELHHDTLMRNAPLQACFSIMNSLGFQGEAVKRTFQSKLAWVVLNVRNVVVLITLASNTPVSVRDKMSPLDEHEVVDTLTGCVKWSLALLSWLADSLFALIKDENFMQRLAVQRFTEIATYLHENNEVALHLILCSSSRSFLSALCRRIAHLEALSNKAIEFYKRQGAAKDANNGARLMNPQLQDAYLRMQQVTTSSLINVVEFEKLLSTLGSDIRQAYQTILPSRIKSGPNPPQGKQLEAAIKTTQVQFEVGMMLTPSPPMAFLGVLKKLMGHDVGAFRELTDPAALFFADYSILGLLDDETSLSAQKASGGSVDLFRKVELKPGALRLGRKRCARCTAVMEDVYVSKAGFTFILSQQRRCSCAGHWTLPVVEGKGAS
Length974
PositionTail
OrganismOphiocordyceps sp. 'camponoti-saundersi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.081
Instability index40.26
Isoelectric point6.29
Molecular weight107657.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21779
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.11|      31|     276|     365|     399|       1
---------------------------------------------------------------------------
  365-  399 (42.97/39.04)	KNTVppVIVTIRSraATEGSFETALSILDRWEAVD
  642-  672 (53.14/32.98)	RNVV..VLITLAS..NTPVSVRDKMSPLDEHEVVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.12|      35|     149|       7|      41|       2
---------------------------------------------------------------------------
    7-   36 (41.73/23.65)	......................PLMLDTA.MSVDLQDVDDLFGDDVGLPISLR
   37-   88 (44.26/25.53)	PQGKQllarldelrsrgccsyvTLLTTPA.AITDDAAIRSVAWSRSGTIASLT
  829-  878 (47.12/27.65)	PQGKQ...leaaikttqvqfevGMMLTPSpPMAFLGVLKKLMGHDVGAFRELT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.05|      50|     149|     115|     195|       3
---------------------------------------------------------------------------
  129-  181 (82.08/61.02)	HLEWSGTANPdlaVVDATGRVAIAGFPISLNQPFVTRK...WDTDVVDDSHAVVGS
  299-  332 (51.72/18.29)	.LRWAGLAGP....SDKAALPQNNRLSPTL.................EETHLAYAS
  517-  567 (71.24/27.93)	KLRWSKLQHP...VVDAANYVPDVRYVATVAALAVTAAssiWYQSNYDDLLAVV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.82|      46|      65|     697|     744|       8
---------------------------------------------------------------------------
  697-  744 (73.33/51.45)	KDENFMQRLAVQRFTEiaTYLHENNEVALHLILCSSSRSFLSALCRRI
  765-  810 (75.48/47.32)	KDANNGARLMNPQLQD..AYLRMQQVTTSSLINVVEFEKLLSTLGSDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21779 with Med16 domain of Kingdom Fungi
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