<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21776

Description Uncharacterized protein
SequenceMTSRPLIGVPPRQPQRAPASHSTAQRPPPHHQRSLSQQYLAPSGSPANRRDSHPEAPGESSEVPQPAAQARHHASTPRRGSSKLRLELSNNDWDPDLATTSDSPQILTPSRAAPALAPPVSDADKVSPAQSRGSQYDDNPPIPLPKRRLQLPERTAPRPRPPAATLAPIKKDARPRPYTVEVPSSAPRFVSIHKHDTPNRDPFSKGLHTGHADFFPWSGNHHEDEWSSEAIQKGTWDRGAQNETSSARLAVLPALKQKSGLNALSTIFMGVMNQRRFRGQILSPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVETVVSGFGEPDWKTRVTYAIRLATNLYSEHLMDRDHYLDWITSNLESSPQSKMPMWILIAQITWADLVRSRKYGRRLVSTLLAQLNNIHNDPDRDILIQLSSQLTGLLKTLLRNNPESFVAPQLWPKHRDALKAFLAPDDGVSQDAWQRVDGRNARLSVGCNTTSPPAGRQHLIKLLDSTIQGYNDRELAVKCLAVTNDKAELVKTLVEWATSVHRPGLAKIYVAVSLIKAWAASNATSVIVDLLDHVSSSDRLRKKAVFHLISELIRAGLFSVPQYIKWLIGRGGLHDAIEIDPDEGPCSSRLLVELPIHCLSESQRLQRTNLLRRAGHYSTADEAKDTANALRCVDGSLGLSQHLGNADVASSKCLSMPKLLRRISNSSKAVQTSIGAHLGDVLTPEVLAKVEPVVALSTFSSARLVLETAQDFTCLSQVLKSYAAASDVEVLAACADTVNSLLDVFLAMGSADALFGALTGRLKSLNREQAAAARPLLVALASLARRLPNRGSIAQQLQRELAQSERSKAIDACSPVSDSMALQAQNGESEVSEQIDKLLASGNTVDPPTMNRLFRNIIPKLEAGWAKADGGRRVFASLLARLRIFDAQHFDKLMADWVSHIGTLKDRPRLLELFPLLISLGCLSMPTVLRSANSVSSTAATDLGSPSDASSVYLQELLQLIVMKLPRIGCLDTVETYRFEIQQRTARLEHAAALLSLIRNAVAEYAAVVGSRDDCPLDEASCRDRLVETLRYLVVADSSAVAKMLDVGTLTAGAVEFIDQMVTRLLAPDGDGGSQESFDQLLSLSNELTMPFCQLKLDVYLSGAEGSSSRLEGFARAMDRAIEARNIAWTKMLPCLSQDITRSLSTQAHARFLGLIPALKSDEEASSSEQQVDLAENLLGVIEAITSPKSAQLTTTLAEKLCDLWGIVASQQEEGIAAATMETVLDRWLPALLRFVVLHCACSDGSQDEVVRGRIILILCGLLLELDSRPRESLSQQVLDVATLLVDGLSDEARMQCAKSILFLPGGGGGGAPSVNVSSDPRLYYLFSIQQPTWAENLKLAHKERASIAYSAAARGMSTLYGIGPASSERLSPYVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKMQ
Length1509
PositionKinase
OrganismOphiocordyceps sp. 'camponoti-saundersi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.206
Instability index47.41
Isoelectric point8.46
Molecular weight164993.32
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1021.96|     239|     242|     920|    1158|       1
---------------------------------------------------------------------------
  499-  713 (190.86/100.47)	....................LLRNNPESFVAP....QLwpkhrDALkafL....APDDGVSQDAWQRVdGRN..ARLSVGcnTTSPPAGR...............QHLIKL...L.D....STIQGY....NDRELAVkclavtndkaELVKTLVEWAtSV..HRPGLAKIYVAVSLIKA...WAASNATSV........IVDLLDHVSSSD...............RLRKKAVfhLISeLIRAglfSVPQYIKwLIGRgglHDA..........IE.IdpDEGPCSSRLLVELPIHCLSESQRLQRtnLL
  723-  918 (175.98/92.02)	DEAKDTANALRcvdGSLG..LSQHLGNADVASskclSM.....PKL...LrrisNSSKAVQTSIGAHL.GDVLTPEVLAK...VEPVVALSTFSS..ARLVLETAQDFTCLsqvLKSYaaASDVEVLaacaDTVNSLL..........DVFLAMGSAD.ALfgALTGRLKSLNREQAAAARPL..........LVALASL.ARRLPNRGSIAQQLQRELA.QSERSKAIDACSP..V..........................................................................
  920- 1147 (354.59/193.32)	..............DSMA..LQAQNGESEVSE....QI.....DKL...L....ASGNTVDPPTMNRL.FRNIIPKLEAG..WAKADGGRRVFASLLARLRIFDAQHFDKL...MADW..VSHIGTL....KDRPRLL..........ELFPLLISLG.CL..SMPTVLRSANSVSSTAATDLGSPSDASSVYLQELLQLIVMKLPRIGCLDTVETYRFE.IQQRTARLEHAAA..LLS.LIRN...AVAEYAA.VVGS...RDD..........CP.L..DEASCRDRLVETLRYLVVADSSAVAK..ML
 1148- 1387 (300.53/162.66)	DVGTLTAGAVE.fiDQMVtrLLAPDGDGGSQE....SF.....DQL...L....SLSNELTMPFCQLK.LDVYLSGAEGS..SSRLEGFARAMDRAIEARNIAWTKMLPCL...SQDI..TRSLST.....QAHARFL..........GLIPALKSDE.EA..S......SSEQQVDLAENLLGVIEAITSPKSAQLTTTLAEKLCDL..WGIVASQQEEgIAAATMETVLDRW..LPA.LLRF...VVLHCAC.SDGS...QDEvvrgriililCGlL..LELDSRPR..ESLSQQVL.D...VAT..LL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.98|      12|      15|     149|     161|       2
---------------------------------------------------------------------------
  149-  161 (20.48/13.50)	LQlPERTAPRPRP
  166-  177 (21.50/ 9.50)	LA.PIKKDARPRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      15|      18|      43|      57|       3
---------------------------------------------------------------------------
   43-   57 (28.25/14.03)	SG...SPANRRDSHPEAP
   60-   77 (22.08/ 9.35)	SSevpQPAAQARHHASTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.98|      16|      18|      95|     111|       5
---------------------------------------------------------------------------
   95-  111 (25.95/22.50)	PDLA.TTSDSPQIlTP..SR
  114-  132 (20.04/10.66)	PALApPVSDADKV.SPaqSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21776 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPLIGVPPRQPQRAPASHSTAQRPPPHHQRSLSQQYLAPSGSPANRRDSHPEAPGESSEVPQPAAQARHHASTPRRGSSKLRLELSNNDWDPDLATTSDSPQILTPSRAAPALAPPVSDADKVSPAQSRGSQYDDNPPIPLPKRRLQLPERTAPRPRPPAATLAPIKKDARPRPYTVEVPSSAPRFVSIHKHDTPNRDPFSKGLHTGHADFFPWSG
1
219










Molecular Recognition Features






MoRF SequenceStartStop




1) TLAPIKKDA
165
173