<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21766

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTILINNIASIAFRVYESPSDTSSHSFVSAVLDVENTLRRDGNLVFYDGARRGLWHFQILAQDQVNSNNLNATLDLCGHELVLVEEGILEPASLQKTRFQQQQPVQTPTSSRSSSSAIDQAQRGGLFTLAPSGNPPAPQEQDPSGVEPKPTSSSHRLVYENFITALLLSISCTFCLRTGAIPLNYRTLLLLSETFEVGSPLDSCLQQCPIAATLKAYVTTTGVLVVSLALSRCRGLSSLAELVTSNLPRSGTPILAAPFGVVANNQISPVGEPGTASLAQTPITQALSLRVVSDGEDSLWKQACLKILKLRGVVSSVVADCAWVHLSVPRPRLQDIKSEAKRQQSSSSSSVTIPWPSPLCFRKKTVDLPCTSRVGDTLRSGFEESHDPLNGARAWFNSAADRDIKVSRRKAERALAVKEAQTMEARAPKPSSPSPAAVRRPSAAAGGTIYPTPPDGIQHHSGVTPSMDGTLSSPGNTLPTAPANDFLASAVGDVVDMGDESKRQRTDNNLLGEADDTFGEMGGDMFGDHDITEADFSFFDEQPGDMDLDTAMNAATLPTEAVIGAEEAPTQCKATTVVPERDDAVFAKPELRHARSSCNDTTSRQRGREARPGSMKREASPFDPHTVFKRLRASLATRRNNKGQASSREPGVFDTMKVDASLIRSINRKYEQGGLFDYTKMAMLEKPKVQPGMLPETDYLKRHGKQRKRSWNGQLKAETFVKGLTGADPPGLQAKADSDDDDSSVSSNDDDSSYSAEEPMSPVKSSIKLMPAEDDVASQVTSLRDADPMEEPDQHLAVELPRLSKPDSPELPLSLLFLDPEPLSLELCLADDDFIQVAQLLTDQAATGLLEVFSGQEAGVTATNVDSPTLATCSRNAVQVLRELMPSLLKGATPANLKGFLDVADVPLLGQPTRLPQRPAVPGRDPGAEPLRPSNLYQIPGPHLEVRRSETKLSVLPSAVLFWESLGLAPSSGGKDVNAVCVFPGWSGMADNVKAFLGCLKSVYEMLKLGSFEKLPLPAGLEAGALPYEVDRISTSPGAAVTEALAESMETLLSAVSSADTPAANMVVYFVYSPNMPATIMEACIAFQRLVSSYRSRTSTMTTATATATATTKPATENEVVLQLVSAKLVSSPTCVVVTPASELVRLSMETYDRCAGKAMPSPAIRLEQPLPRIIDFKLTVSPSASLMRENSCIHIAYAQSVDDRWITAAWTDDRGNQQETVSYCLGRKGRPPSRSISDVAKDMWELTVDLISVWKVHWRVVITKCSPMDQQEMDFWADRARTEVKASVTMILMTVDTNPSLQLLPPAVKLTTTTMTTTTTSTPTPTSTAATTATAATTAATTTLSPEQTESEAEAVLSDVTDQTWGAVVSHRFNVSFSALDLRSSSLASGYLIKRTGSRTEDAPVLMEVNLVHADASPRSYEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHIAAAEKAVRALYLLM
Length1479
PositionKinase
OrganismOphiocordyceps sp. 'camponoti-saundersi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.243
Instability index49.56
Isoelectric point5.29
Molecular weight159662.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21766
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.23|      23|      28|     624|     650|       1
---------------------------------------------------------------------------
  624-  650 (35.92/31.15)	KREASPFDPHTVFkrlrASLATRRNNK
  655-  677 (40.31/24.67)	SREPGVFDTMKVD....ASLIRSINRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.99|      26|      27|     455|     480|       2
---------------------------------------------------------------------------
  455-  480 (50.21/25.90)	GTIYPTPPDGIQHHSGVTPSMD.GTLS
  483-  509 (40.78/19.74)	GNTLPTAPANDFLASAVGDVVDmGDES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      13|      21|     521|     539|       3
---------------------------------------------------------------------------
  521-  533 (26.70/27.68)	EAD.DTFGEMGGDM
  541-  554 (22.50/ 6.60)	EADfSFFDEQPGDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.44|      20|      21|    1320|    1339|       4
---------------------------------------------------------------------------
 1320- 1339 (34.88/18.79)	TTTTMTTTTTSTPTPTSTAA
 1343- 1362 (32.56/17.01)	TAATTAATTTLSPEQTESEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.57|      26|      28|     245|     272|       5
---------------------------------------------------------------------------
  245-  272 (39.23/24.72)	SSLAELVTSNLPRsgTPILAA.PFGVVAN
  276-  302 (40.33/19.67)	SPVGEPGTASLAQ..TPITQAlSLRVVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.82|      14|      29|     790|     808|       8
---------------------------------------------------------------------------
  790-  808 (15.95/24.39)	SLRDADPmeEPdqhLAVEL
  822-  835 (25.87/15.06)	SLLFLDP..EP...LSLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.17|      18|      25|     568|     590|      10
---------------------------------------------------------------------------
  558-  575 (29.54/11.67)	TAMNAAT.LP..TEAVIGAEE
  578-  598 (23.63/24.90)	TQCKATTvVPerDDAVFAKPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.42|      30|     143|    1013|    1047|      11
---------------------------------------------------------------------------
  917-  949 (49.21/22.63)	LGQPTRLPQrPAvpGRDPGAEPLRPSNLYQIPG
 1017- 1046 (54.21/27.52)	LGSFEKLPL.PA..GLEAGALPYEVDRISTSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.64|       8|      25|     963|     974|      12
---------------------------------------------------------------------------
  963-  974 ( 9.84/12.36)	VLPSavlfWESL
  990-  997 (17.80/ 8.34)	VFPG....WSGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.10|      72|     294|      81|     158|      13
---------------------------------------------------------------------------
   81-  158 (110.00/72.80)	TLDL.C....GHELVLVEEGILEPASLQKTRFQQQQPVQTPTSSRSSSSAIDQAQRGGLFTLAPsgNPPAPqeqDPSGVEpKP
  373-  449 (113.10/59.17)	TVDLpCtsrvGDTLRSGFEESHDPLNGARAWFNSAADRDIKVSRRKAERALAVKEAQTMEARAP..KPSSP...SPAAVR.RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.43|      13|      34|    1085|    1100|      15
---------------------------------------------------------------------------
 1085- 1100 (15.44/25.34)	PATimEACIAFQrLVS
 1122- 1134 (22.99/17.00)	PAT..ENEVVLQ.LVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21766 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDVASQVTSLRDADPMEEPDQHLAVELPRLS
2) HDITEADFSFFDEQPGDMDLDTAMNAATLPTEAVIGAEEAPTQCKATTVVPERDDAVFAKPELRHARSSCNDTTSRQRGREARPGSMKREASPFDP
3) KMAMLEKPKVQPGMLPETDYLKRHGKQRKRSWNGQLKAETFVKGLTGADPPGLQAKADSDDDDSSVSSNDDDSSYSAEEPMSPVKSSIKLMPA
4) SRRKAERALAVKEAQTMEARAPKPSSPSPAAVRRPSAAAGGTIYPTPPDGIQHHSGVTPSMDGTLSSPGNTLPTAPANDFLASAVGDVVDMGDESKRQRTDNNLLGEADDTFGEMGGDMFG
5) TTTMTTTTTSTPTPTSTAATTATAATTAATTTLSPEQTESEAEAVL
6) TVFKRLRASLATRRNNKGQASSREPGVFDTMKV
782
537
688
415
1321
634
812
632
780
535
1366
666










Molecular Recognition Features






MoRF SequenceStartStop




1) HDITEADFSFF
2) HTVFKRLRA
537
633
547
641