<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21764
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDGSDESKAALQTSWRYWTHFMFKCIVHSPKPEIDQFRGFAQYLNRQYPLPPIFIADVFLKPIYGNITLTPQFPIYVKALCQLGLVDVSSVLVALCKYSSLNAYIRHPSRTGEDAEDHVQSPNNLEQRRIWRVSSWFEEFFFYQLIRTLVDGSAFRDIRSTLVLVKIVCKWMALFTAASAAVATDILAEVQQARERDGLPRGQEDLETSRAAFLPFLTRLVETPALVDALRHPIARDVRRELLETLTRFRHTLPPDTNFGERLDMFRCETLARLDPLPKNRQADAMDEFLEPVMRLENFAIPDIPIPNSRAGLYVYLNAALVGRPLIDDAMLISFLHNRYQGETQSSAIDLIVASFDILANTVFRSEGPKDAHLLRSFLINKLPLLLCQLFASQFSTASSEYCITEALNQVDTSVFPTASLMFDETRSNNPYTESVREDFCTACALHGLVRREHVERILGETSMSYEPSLEKYSKDKLVQSCLSDPDRIQGLVRDIDKMDGNVGAICQALVELMRQLCDSKETMSLKLLCSQLAHKPQSLDILLLFERLPAVLEPLCQLLDNWRYDDDQGEYQPIYEEFGGILLLVLAYAYRYNLRAADIGIVSSDSCVAKILDRAHISRPLDELTEQEKTHVNGWIHGLFGSETGGLGDDLMSSCPPQDFYLVVASLFQYIVSAYTHGYLNVESLKSGIEYVVDTFLLPSLVPAIRFLADYLWVDQKEQKSVIKILQLILLPSSISGEASAMLSSVKNLIAKPLEYSLRSYQKQDPKNQDIEPLLRALRDNLPLSRRTGGAEHHELDSWSNSSSSGLSGAIRHTVQGLVQMHHGVNVMPTSYTHRQTIAACRIVGTRRVLRAMLDEIRHQPEAYDVVTMLVCAPDVTIESPASGLLEAAGSAASQRRLTLREALKAESESCLKPNKKEEAETVVRLHRRVEAMLALPAAATMLEAPDIPSLDLSGGPGALVTGGMAAVAQGAGGGMMMEAVGLDMALGSASSDLGLGGVGGGGLEAANEGEMFCRTLDPQLEIYWGDGMNTSGG |
Length | 1035 |
Position | Tail |
Organism | Ophiocordyceps sp. 'camponoti-saundersi' |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.079 |
Instability index | 44.52 |
Isoelectric point | 5.26 |
Molecular weight | 114987.31 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21764
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.16| 15| 18| 662| 676| 1
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662- 676 (26.61/17.18) YLVVASL...FQYIVSAY
680- 697 (21.55/12.63) YLNVESLksgIEYVVDTF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.97| 16| 18| 779| 795| 5
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779- 795 (25.68/23.57) LrDNLPLSRRTG..GAEHH
797- 814 (25.28/16.86) L.DSWSNSSSSGlsGAIRH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 74.89| 18| 19| 220| 237| 6
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220- 237 (31.72/20.24) LVETPALVDALRHPIARD
242- 256 (26.29/15.40) LLET...LTRFRHTLPPD
268- 281 (16.89/ 7.03) .CETLARLDPL..PKNR.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 101.01| 35| 228| 56| 117| 9
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56- 94 (53.47/27.97) ADV...FLKPIY..GNITLtPQFPIyvkALCQLGL.VDVSSVLVA
283- 323 (47.54/ 6.17) ADAmdeFLEPVMrlENFAI.PDIPI...PNSRAGLyVYLNAALVG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.08| 21| 192| 446| 468| 13
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446- 468 (33.44/28.50) LHGLVRREhvERILGETSMSYEP
637- 657 (38.65/25.32) IHGLFGSE..TGGLGDDLMSSCP
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