<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21764

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGSDESKAALQTSWRYWTHFMFKCIVHSPKPEIDQFRGFAQYLNRQYPLPPIFIADVFLKPIYGNITLTPQFPIYVKALCQLGLVDVSSVLVALCKYSSLNAYIRHPSRTGEDAEDHVQSPNNLEQRRIWRVSSWFEEFFFYQLIRTLVDGSAFRDIRSTLVLVKIVCKWMALFTAASAAVATDILAEVQQARERDGLPRGQEDLETSRAAFLPFLTRLVETPALVDALRHPIARDVRRELLETLTRFRHTLPPDTNFGERLDMFRCETLARLDPLPKNRQADAMDEFLEPVMRLENFAIPDIPIPNSRAGLYVYLNAALVGRPLIDDAMLISFLHNRYQGETQSSAIDLIVASFDILANTVFRSEGPKDAHLLRSFLINKLPLLLCQLFASQFSTASSEYCITEALNQVDTSVFPTASLMFDETRSNNPYTESVREDFCTACALHGLVRREHVERILGETSMSYEPSLEKYSKDKLVQSCLSDPDRIQGLVRDIDKMDGNVGAICQALVELMRQLCDSKETMSLKLLCSQLAHKPQSLDILLLFERLPAVLEPLCQLLDNWRYDDDQGEYQPIYEEFGGILLLVLAYAYRYNLRAADIGIVSSDSCVAKILDRAHISRPLDELTEQEKTHVNGWIHGLFGSETGGLGDDLMSSCPPQDFYLVVASLFQYIVSAYTHGYLNVESLKSGIEYVVDTFLLPSLVPAIRFLADYLWVDQKEQKSVIKILQLILLPSSISGEASAMLSSVKNLIAKPLEYSLRSYQKQDPKNQDIEPLLRALRDNLPLSRRTGGAEHHELDSWSNSSSSGLSGAIRHTVQGLVQMHHGVNVMPTSYTHRQTIAACRIVGTRRVLRAMLDEIRHQPEAYDVVTMLVCAPDVTIESPASGLLEAAGSAASQRRLTLREALKAESESCLKPNKKEEAETVVRLHRRVEAMLALPAAATMLEAPDIPSLDLSGGPGALVTGGMAAVAQGAGGGMMMEAVGLDMALGSASSDLGLGGVGGGGLEAANEGEMFCRTLDPQLEIYWGDGMNTSGG
Length1035
PositionTail
OrganismOphiocordyceps sp. 'camponoti-saundersi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.08
Grand average of hydropathy-0.079
Instability index44.52
Isoelectric point5.26
Molecular weight114987.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21764
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.16|      15|      18|     662|     676|       1
---------------------------------------------------------------------------
  662-  676 (26.61/17.18)	YLVVASL...FQYIVSAY
  680-  697 (21.55/12.63)	YLNVESLksgIEYVVDTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.97|      16|      18|     779|     795|       5
---------------------------------------------------------------------------
  779-  795 (25.68/23.57)	LrDNLPLSRRTG..GAEHH
  797-  814 (25.28/16.86)	L.DSWSNSSSSGlsGAIRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.89|      18|      19|     220|     237|       6
---------------------------------------------------------------------------
  220-  237 (31.72/20.24)	LVETPALVDALRHPIARD
  242-  256 (26.29/15.40)	LLET...LTRFRHTLPPD
  268-  281 (16.89/ 7.03)	.CETLARLDPL..PKNR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.01|      35|     228|      56|     117|       9
---------------------------------------------------------------------------
   56-   94 (53.47/27.97)	ADV...FLKPIY..GNITLtPQFPIyvkALCQLGL.VDVSSVLVA
  283-  323 (47.54/ 6.17)	ADAmdeFLEPVMrlENFAI.PDIPI...PNSRAGLyVYLNAALVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.08|      21|     192|     446|     468|      13
---------------------------------------------------------------------------
  446-  468 (33.44/28.50)	LHGLVRREhvERILGETSMSYEP
  637-  657 (38.65/25.32)	IHGLFGSE..TGGLGDDLMSSCP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21764 with Med5 domain of Kingdom Fungi
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