<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21763

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKLIDSRFERLEKALSNLVDSVTKYHPSVSQAEELHAADAQLSLGLEEVQVHQNNNLHIQQLRRTSAALDSQIRDTLTSLATTRKDIVATQITKFSSEPSYPVAYDELLAYARRISKTTLPPAANLLTAFPSPEMLTPAAATATAEQPPSAATPSGRTPSRTESPVANGASAQLPNAEQPAQQTSASQNTSLPEGMSQYLNPLSGQVFFPWPLEDKIRSGALASYQLLVEQGIDPRGYDPATEEERKRKEDEERKAKEEREKAEREERERQLREERERLRVERERQREKDQEEWRKTSIATGMPGAAVPVRSASGAGDKKQFQFTNLDDDDDDDDEG
Length338
PositionMiddle
OrganismOphiocordyceps sp. 'camponoti-saundersi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.919
Instability index57.41
Isoelectric point4.95
Molecular weight37686.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21763
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.94|      14|      15|     254|     267|       1
---------------------------------------------------------------------------
  254-  267 (23.77/13.46)	ERKAKEERE..KAERE
  270-  285 (20.16/10.35)	ERQLREERErlRVERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.77|      13|      29|     100|     113|       3
---------------------------------------------------------------------------
  100-  112 (23.68/17.68)	PSYPVAYDELLAY
  119-  131 (22.08/10.17)	TTLPPAANLLTAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.49|      13|      29|      30|      43|       4
---------------------------------------------------------------------------
    7-   19 (19.37/ 6.49)	SRFERLEKALSNL
   31-   43 (22.12/14.09)	SQAEELHAADAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.13|      18|      30|     199|     219|       5
---------------------------------------------------------------------------
  199-  219 (26.84/27.16)	QYLNPlSGqvFFPWPLEDKIR
  232-  249 (33.29/20.81)	QGIDP.RG..YDPATEEERKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21763 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LASYQLLVEQGIDPRGYDPATEEERKRKEDEERKAKEEREKAEREERERQLREERERLRVERERQREKDQEEWRKTSIATGMPGAAVPVRSASGAGDKKQFQFTNLDDDDDDDDEG
2) LLTAFPSPEMLTPAAATATAEQPPSAATPSGRTPSRTESPVANGASAQLPNAEQPAQQTSASQNTSLPEGMSQYLN
223
127
338
202










Molecular Recognition Features






MoRF SequenceStartStop




1) AYDEL
2) WRKTSIATGMPGAAVPVRSASGAGDKKQFQFTNLDDDDDDDDEG
105
295
109
338