Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKLIDSRFERLEKALSNLVDSVTKYHPSVAQAEELHAADAQLSLGLEEVQVHQNNNLHIQQLRRTSAALDTQIRDTLTSLATTRKDIVATQTTKFSAKPSYPVAYDELLAYARRISKTTLPPAASLLTAAPSPETSTPTAATAAAEQPPSAVTPSGRTPSRTESPVANGASVQLSNAEQPAQQTSASQNTSLPEGMSQYLNPLSGQVFFPWPLEDKIRSGALASYQILVEQGIDPRGYDPATEEERKRKEEEERKAKEEREKAEREERERQLREERDKLRIERDKQREKDQEAWRKTSIATGVPGAAVPVRSASGAGDKKQFQFTNLDDDDDDDDEG |
Length | 338 |
Position | Middle |
Organism | Ophiocordyceps sp. 'camponoti-leonardi' |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.891 |
Instability index | 53.07 |
Isoelectric point | 5.08 |
Molecular weight | 37395.74 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21757 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.90| 15| 15| 252| 266| 1 --------------------------------------------------------------------------- 252- 266 (25.14/16.02) EEERKAKEEREK..AER 268- 284 (20.76/11.92) ERERQLREERDKlrIER --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 85.60| 29| 29| 142| 170| 2 --------------------------------------------------------------------------- 128- 159 (42.81/19.50) LTAAPSPETSTptaATAAAEQPPSAVTPSGRT 160- 191 (42.79/19.49) PSRTESPVANGasvQLSNAEQPAQQTSASQNT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGDKKQFQFTNLDDDDDDDDEG 2) AWRKTSIATGVPGAAVPVRSA 3) VAYDELLAYAR | 317 294 104 | 338 314 114 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab