<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21751

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTVLINNIASIAFRVYESPSDTSSHSFASAALEVENTLRRDGHVVFYDGARRGLWHFQILAQDQINSNNLNATLDLCGHELVLVEEGILEPASLQKTRSQQQQPVQTPTSSRSSSSALDQSQRSGLLPLAPPGNPSTSQEQDPSGVEPKPTTSSYRLVYENFITALLLSISCAFCRRTGAIPLNYRTLLLLSETLEVGNPLDSCPQQCPIAGTLKAYVTTTGVLVVSFALSRCRGLSSLAELVSCTLPRSGTPVLAAPFGVVASIHLSPAGEPGTASIAQTPITQALSLRVVSDGEDSLWKQACLKILKLRGVISSVVADCAWVNLSVPRPRLQDVKSEAKRQQPSSSTVTIPWPSPLCFRKKTVDLPCTSRVGDMLRSGFEESHDPLSSAKGWFNSAADREQKVSKRKAERALALKETQILEARAPKPSSPSPAAVRRPSAAAGSTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAPSSDFLTSTVGDAMDMSDESKRQRADNNLLGEADDTFGEMGGDMFGDHDITEADFSFFDEQPGDMDLDTAMDAATLPTEAVVGAEEAASQCQATNVPARDDAVFAKPELRHARSSCMDITPGQRGRETRSAPMKREASPFDPHTVFKRLRASLATTTGGRNVKGQTSSRGQRVFDTMKVDASLIRSINKKYEQGGLFDYTKMANLEKPKVQQATLPETDYLKRHGKQRKRSWNGQFKAETFMKGLMGSEPSGLQAKVDSEDEDSSASSDDADSSYSAEEPMSPVKSSIKMMPVEDDVASQVTSVRDGDPMEEPDQHLAAELPRLSKPDFPELPLSLLFLDPEPLSLELCLADDDFIQVAQLLTDQAATGLLDMFSGQEGGAAVGTNLDSPTLTTCARNSVQVLRELMPTLLKGAAPANLKGFLDVADVPLLGQPTRLQQRPVVPGRDPGTESLRPSNLYQIPGPHLEVRRSETKLSVLPSAVLFWESLGLAPSSGGKDVNAVCVFPGWSGMADNVKAFLGCLKSVYEMLKLGSFERLALPAGLEAGALPYEVDRISTSPGAAVTGALAESMETLLSAVSSADTPAANMVVYFVYSPNMPASIMEACIAFQRLASSYQIKTSTITATTAPTTTTTTTTTTTTTTTTTSTAATPKSPTTQSEVVLQLVSAKLVSSPTCVVVTPAPELVRLSMETYDRCAGKAMPSPAIRLEQPLPRIIDFKLTVSPSASLMRENSCIHIAYAQSVDDRWITAAWTDDRGNQQETASYCLGRKGRPPSRSISDVAKDMWELTVDLISMWKVHWRVVITKCSPMDQQEMDFWADRARTEVKASVTMILMTVDTNPSLQLLPPAVKLSMMTTTTTTTPPTAETTTTTTAATSTVSPDQTETESEAVLSDVTDQTWGAVVSHRFNVSLSALDMRSSSLASGYLIKRTGSRAEDAPVLMEVNLVHADASPRSYEPLLREMLSYFRGLGTLARARGVVQREVDVRPWHVAAAEKAVRALYLLM
Length1493
PositionKinase
OrganismOphiocordyceps sp. 'camponoti-leonardi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.253
Instability index49.87
Isoelectric point5.29
Molecular weight161030.30
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21751
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.25|      11|      25|    1108|    1119|       1
---------------------------------------------------------------------------
 1116- 1126 (23.33/ 6.73)	APTTTTTTTTT
 1350- 1360 (21.91/10.59)	TPPTAETTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.02|      16|      18|     520|     537|       2
---------------------------------------------------------------------------
  520-  537 (28.73/25.96)	EAD.DTFGEMGGDMfgDHD
  540-  556 (28.28/17.20)	EADfSFFDEQPGDM..DLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     459.77|     155|     224|     950|    1173|       3
---------------------------------------------------------------------------
  950- 1154 (220.44/244.91)	PGPHLEV.....RRSETKLSVLPSAVLFWESlGLAPSSGGKDVNAVCVFPGWSGMADNvkaflgclksvyemlklgsferlalpaglEAGALPYEVDRISTSPGAAVTGALAESMETLLSAVSSADTPAanMVVYFVYSP...............NMPASI......MEACIAFQRLASSyqIKTSTItattaptttttttttTTTTTT.............TTSTaATPKSPTTQSEVVLQLV
 1190- 1383 (239.33/150.86)	PSPAIRLeqplpRIIDFKLTVSPSASLMREN.SCIHIAYAQSVDDRWITAAWTDDRGN.............................QQETASYCLGRKGRPPSRSISDVAKDMWELTVDLISMWKVHW..RVVITKCSPmdqqemdfwadrartEVKASVtmilmtVDTNPSLQLLPPA..VKLSMM...............TTTTTTtpptaettttttaATST.VSPDQTETESEAVLSDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.92|      66|     222|     197|     266|       4
---------------------------------------------------------------------------
  197-  266 (101.38/52.23)	LLLSET..LEVGNPLDSCPQqcPIAgtLKAYVTTTGVLVVSFALSRCRGLSSLAELVSCTLPRSGTPVLAAP
  422-  489 (111.54/48.15)	LALKETqiLEARAPKPSSPS..PAA..VRRPSAAAGSTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.04|      24|      33|     608|     640|       5
---------------------------------------------------------------------------
  608-  633 (39.96/35.67)	TPGqrGRETRSAPMKREASPFDPHTV
  644-  667 (42.08/17.55)	TTG..GRNVKGQTSSRGQRVFDTMKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.13|      32|     224|     683|     721|       7
---------------------------------------------------------------------------
  676-  707 (55.77/44.91)	NKKYEQGGLFD.YTKMANL..EKPKVQQATLPETD
  715-  749 (47.36/23.03)	QRKRSWNGQFKaETFMKGLmgSEPSGLQAKVDSED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      16|     631|     375|     390|      10
---------------------------------------------------------------------------
  375-  390 (31.48/21.49)	LPCTSRVGDMLRSG.FE
 1007- 1023 (25.80/16.21)	LGCLKSVYEMLKLGsFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21751 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDVASQVTSVRDGDPMEEPDQHLAAELPRL
2) GSEPSGLQAKVDSEDEDSSASSDDADSSYSAEEPMSPVKSSIKMMPV
3) HDITEADFSFFDEQPGDMDLDTAMDAATLPTEAVVGAEEAASQCQATNVPARDDAVFAKP
4) PAVKLSMMTTTTTTTPPTAETTTTTTAATSTVSPDQTETESEAVL
5) QSQRSGLLPLAPPGNPSTSQEQDPSGVEPKP
6) RHARSSCMDITPGQRGRETRSAPMKREASPFDP
7) SAKGWFNSAADREQKVSKRKAERALALKETQILEARAPKPSSPSPAAVRRPSAAAGSTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAPSSDFLTSTVGDAMDMSDESKRQRADNNLLGEADDTFGEMGGDMFG
8) TATTAPTTTTTTTTTTTTTTTTTSTAATPKSPT
9) TVFKRLRASLATTTGGRNVKGQTSSRGQRVFD
783
735
536
1336
128
598
398
1112
632
812
781
595
1380
158
630
534
1144
663










Molecular Recognition Features






MoRF SequenceStartStop




1) HDITEADFSFF
2) TQILE
3) VFKRLRA
536
427
633
546
431
639