<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21751

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTVLINNIASIAFRVYESPSDTSSHSFASAALEVENTLRRDGHVVFYDGARRGLWHFQILAQDQINSNNLNATLDLCGHELVLVEEGILEPASLQKTRSQQQQPVQTPTSSRSSSSALDQSQRSGLLPLAPPGNPSTSQEQDPSGVEPKPTTSSYRLVYENFITALLLSISCAFCRRTGAIPLNYRTLLLLSETLEVGNPLDSCPQQCPIAGTLKAYVTTTGVLVVSFALSRCRGLSSLAELVSCTLPRSGTPVLAAPFGVVASIHLSPAGEPGTASIAQTPITQALSLRVVSDGEDSLWKQACLKILKLRGVISSVVADCAWVNLSVPRPRLQDVKSEAKRQQPSSSTVTIPWPSPLCFRKKTVDLPCTSRVGDMLRSGFEESHDPLSSAKGWFNSAADREQKVSKRKAERALALKETQILEARAPKPSSPSPAAVRRPSAAAGSTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAPSSDFLTSTVGDAMDMSDESKRQRADNNLLGEADDTFGEMGGDMFGDHDITEADFSFFDEQPGDMDLDTAMDAATLPTEAVVGAEEAASQCQATNVPARDDAVFAKPELRHARSSCMDITPGQRGRETRSAPMKREASPFDPHTVFKRLRASLATTTGGRNVKGQTSSRGQRVFDTMKVDASLIRSINKKYEQGGLFDYTKMANLEKPKVQQATLPETDYLKRHGKQRKRSWNGQFKAETFMKGLMGSEPSGLQAKVDSEDEDSSASSDDADSSYSAEEPMSPVKSSIKMMPVEDDVASQVTSVRDGDPMEEPDQHLAAELPRLSKPDFPELPLSLLFLDPEPLSLELCLADDDFIQVAQLLTDQAATGLLDMFSGQEGGAAVGTNLDSPTLTTCARNSVQVLRELMPTLLKGAAPANLKGFLDVADVPLLGQPTRLQQRPVVPGRDPGTESLRPSNLYQIPGPHLEVRRSETKLSVLPSAVLFWESLGLAPSSGGKDVNAVCVFPGWSGMADNVKAFLGCLKSVYEMLKLGSFERLALPAGLEAGALPYEVDRISTSPGAAVTGALAESMETLLSAVSSADTPAANMVVYFVYSPNMPASIMEACIAFQRLASSYQIKTSTITATTAPTTTTTTTTTTTTTTTTTSTAATPKSPTTQSEVVLQLVSAKLVSSPTCVVVTPAPELVRLSMETYDRCAGKAMPSPAIRLEQPLPRIIDFKLTVSPSASLMRENSCIHIAYAQSVDDRWITAAWTDDRGNQQETASYCLGRKGRPPSRSISDVAKDMWELTVDLISMWKVHWRVVITKCSPMDQQEMDFWADRARTEVKASVTMILMTVDTNPSLQLLPPAVKLSMMTTTTTTTPPTAETTTTTTAATSTVSPDQTETESEAVLSDVTDQTWGAVVSHRFNVSLSALDMRSSSLASGYLIKRTGSRAEDAPVLMEVNLVHADASPRSYEPLLREMLSYFRGLGTLARARGVVQREVDVRPWHVAAAEKAVRALYLLM
Length1493
PositionKinase
OrganismOphiocordyceps sp. 'camponoti-leonardi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.253
Instability index49.87
Isoelectric point5.29
Molecular weight161030.30
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21751
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.25|      11|      25|    1108|    1119|       1
---------------------------------------------------------------------------
 1116- 1126 (23.33/ 6.73)	APTTTTTTTTT
 1350- 1360 (21.91/10.59)	TPPTAETTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.02|      16|      18|     520|     537|       2
---------------------------------------------------------------------------
  520-  537 (28.73/25.96)	EAD.DTFGEMGGDMfgDHD
  540-  556 (28.28/17.20)	EADfSFFDEQPGDM..DLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     459.77|     155|     224|     950|    1173|       3
---------------------------------------------------------------------------
  950- 1154 (220.44/244.91)	PGPHLEV.....RRSETKLSVLPSAVLFWESlGLAPSSGGKDVNAVCVFPGWSGMADNvkaflgclksvyemlklgsferlalpaglEAGALPYEVDRISTSPGAAVTGALAESMETLLSAVSSADTPAanMVVYFVYSP...............NMPASI......MEACIAFQRLASSyqIKTSTItattaptttttttttTTTTTT.............TTSTaATPKSPTTQSEVVLQLV
 1190- 1383 (239.33/150.86)	PSPAIRLeqplpRIIDFKLTVSPSASLMREN.SCIHIAYAQSVDDRWITAAWTDDRGN.............................QQETASYCLGRKGRPPSRSISDVAKDMWELTVDLISMWKVHW..RVVITKCSPmdqqemdfwadrartEVKASVtmilmtVDTNPSLQLLPPA..VKLSMM...............TTTTTTtpptaettttttaATST.VSPDQTETESEAVLSDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.92|      66|     222|     197|     266|       4
---------------------------------------------------------------------------
  197-  266 (101.38/52.23)	LLLSET..LEVGNPLDSCPQqcPIAgtLKAYVTTTGVLVVSFALSRCRGLSSLAELVSCTLPRSGTPVLAAP
  422-  489 (111.54/48.15)	LALKETqiLEARAPKPSSPS..PAA..VRRPSAAAGSTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.04|      24|      33|     608|     640|       5
---------------------------------------------------------------------------
  608-  633 (39.96/35.67)	TPGqrGRETRSAPMKREASPFDPHTV
  644-  667 (42.08/17.55)	TTG..GRNVKGQTSSRGQRVFDTMKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.13|      32|     224|     683|     721|       7
---------------------------------------------------------------------------
  676-  707 (55.77/44.91)	NKKYEQGGLFD.YTKMANL..EKPKVQQATLPETD
  715-  749 (47.36/23.03)	QRKRSWNGQFKaETFMKGLmgSEPSGLQAKVDSED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      16|     631|     375|     390|      10
---------------------------------------------------------------------------
  375-  390 (31.48/21.49)	LPCTSRVGDMLRSG.FE
 1007- 1023 (25.80/16.21)	LGCLKSVYEMLKLGsFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21751 with Med13 domain of Kingdom Fungi
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