<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21749

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTADKMPLMLDNAMSVDLQDVDDLFGDDVALPITLRPQRKQLLARLDELRSRGCCSSVAWSRSGTIASLTPDGQSIQLRFISCQPENGSWELSEPTTCETIKGTPAIPLVHLEWSATTCPELAVLDAIGRVAIASFPISLNQPFVTRKWDADVVDDSHAIVGSYWLPVGPSAQQKQPYNIIHGPAKRHGNSYQYETSFLYAGGPCHPHSSKSALLCITMGGMLKMYWWQNTNRIEETLMELESVNSSDELTANDSIPEFLLVALATSSFTLKLLRLDLRWAGLGPASDKSAQLQNPRLSPKLDETHLAYASWLHSGPNEPNHDPSVAALSYLHVLPSMLDNTGKSTVPPVIVTIRSRAAEEGSFETALSILDRWEAVEERQTVPAAFEQLGNRRHGLSSDLPSLTRLRKLEPIIINKVVIGLQTIHFGKILLITMSDGTVEHRDRYSFEEVFNAEDLTRVMNLRQVGWNFADSGPCQQVAFSPTQCSMMLLADDGKLRWSKLYHPIIDSADYVQDARYVATIAALAVTVASCVWYQSNYDDLLAVVHPMATRNRFTQEWVSELIRILKIQIDYTEELHHDTLMRNAPLQACFSIMNSLGFRGEAVKRTFQSKLAWVILNVRNVVVLITLASNTPITIRDKMSPLDEHEVVDVLTGCVKWSLALLSWLADSLFALIKDENFMQRLAPQRFAEMATYLHQKNEMALHLILCSSSRSFLSALCRRVSHLEAISNKAIDFYRRQGDPDDPNNVARLSDPQLQEAYLRMQQVTTSSLIKVTDFEKLLNTLSSDIRQAYHTILHNRLKNGPNPPQGKQLEAAVKTAQVQIEVGVMLTSSPPIALMPVLKKLMGHDVGVFRGLTDPAALFFADYSLLGLLDDEMSLSARIASGVSVDLFRKIELKPGGFRPGRRRCARCTAIMGDVYVSKAGFTFILSQQRRCSCSGHWTLPLPVEDMDLS
Length954
PositionTail
OrganismOphiocordyceps sp. 'camponoti-leonardi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.106
Instability index45.88
Isoelectric point6.11
Molecular weight106400.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     342.94|     111|     130|      83|     212|       1
---------------------------------------------------------------------------
   17-  139 (161.83/115.75)	DLQDVDD...LFGdDVALPITLRPQRKQLLARLDELRSR.GccSSVAWSRSGTIASLTPDGQSIQLrfisCQPENGSWELSEPTTCETIKGTpaipLVHLEwSATTCPELAVLDAIGR...VAIASFPIS
  150-  270 (181.10/145.53)	DADVVDDshaIVG.SYWLPVGPSAQQKQPYNIIHGPAKRhG..NSYQYETSFLYAGGPCHPHSSKS.allCITMGGMLKMYWWQNTNRIEET....LMELE.SVNSSDELTANDSIPEfllVALATSSFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      10|      16|     308|     317|       2
---------------------------------------------------------------------------
  308-  317 (21.05/11.70)	AYASWLHSGP
  327-  336 (18.22/ 9.21)	AALSYLHVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.27|      41|     196|     430|     625|       4
---------------------------------------------------------------------------
  432-  473 (69.49/31.25)	LITMSDGT.VEHRDRYS.FEEVFNAEDLTRVM..NLRQVGWnFADS
  626-  670 (55.78/207.91)	LITLASNTpITIRDKMSpLDEHEVVDVLTGCVkwSLALLSW.LADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.22|      21|      21|     827|     847|       8
---------------------------------------------------------------------------
  827-  847 (37.25/19.81)	GVMLTSSPPIALMPVLKKLMG
  851-  871 (36.97/19.61)	GVFRGLTDPAALFFADYSLLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21749 with Med16 domain of Kingdom Fungi
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