<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21745

Description Uncharacterized protein
SequenceMTSRPPIVGVPPRQSHRAPASHSAVQRPSTHHQRSLSQQYLAPSASPAVRRDSHPEAPGEPSDVPQPAAAAAQARHHASTPRRGSSKLRLELSNVDWDPDLATTSDSPQILTPSRTAPVLAPPVSDADKVSPAQSRGSQYDDNPPIPLPKRRLQLPERTVSTPRPSAAIVAPTKKDARPRPYTVEVPSSAPRFVSIRKNDTPNRDPFSKGLHTGHADFFPWSGHHHEDEWSSEAIQKGTWDRGAQNETSSARLAVLPALKQKSGLNALSTIFMGVMNQRRFRGQILSPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVETVVSAFGEPDWKTRVTYAIRLATNLYSEHLMDRDHYLDWITSNLESSPQSRMPMWILIAQITWADLVRSRKYGRRLVYTLLAQLNSIHNDPDRDILIQLSSQLTGLLKTLLRSNPESFVAPQLWPKHREALKAFLPPDDGVSQDAWQCVDGRNARLSVGCNTASPPAGRQHLIKLLDSTIQGHSDRELAAKCLAVTNDKAELVKTLVEWATSIHRPGLAKLYIAVSLIKEWAASDVTSVIVDLLDHVSSSDRLRKKAIFHLVSELIRAGLFSVSKYVKWLIGRGGLHDAAEIDPDEGPCSSRLLVELPIHCLTESQRLQRTNLLWRAGHYSTAEEAKDIANALRCVDGSLGLSQHLGNTDAASAKCLSMPKLLRRISNSSKAVQTSIGAHLRDVLTPELLAKVEPVVALSTFSSARLVLETARDFTCLSQVLKSYAAASDVEVLAACADTVNSLLDVFLAMGTADALFSALAGRLKSLNREQAAAARPLLVALASLARRLPNRGSLAQQLQRELAQSERSKAIDACSPVSDSMAMQAAPTGESEVSEQIDKLLASGNTVDPPTMNRLFRNIIPKLEAGWAKTDGRRRVFASLLARLRIFDAQHFDKLMADWVSHVGTLKDRPRLLELFPLLMSLGCLSIPTVLRSANSASSTDPGSASDASSIYLQELLQLIVMKLPRAGCLDTVETYRFEVQQRTARLEHAGALLSLIRNAVAEYAAVMGSRNDCPLDDTFCRDCLVETLRYLVATDSSAVAKVLDVGTLAAGAVEFVDQMVTRLLAPDGDGGSQESFDQLLSLSNELTMPFCQLKLDVYLSGAEKSTARLEGFARAMDRAIEARNISWTKMLPCLSQDITRSLSMQAHARFLGLVPSLKSEGEASSEQAVDLAENLLGVIEAITSPQSAQLTTALAEKLCDLWGIIASQKEEGTTTTTTTTTTTTTTTLTEMVLDRWLPALLRFVVLHGVCAEGSQDDAVRSRIILVLCGLLLELDSRPRGSLSQHVLDVATLLVDGLPDEARIQCAKNILFLPGGGSVGGPSGVNTSSDPRLYYLFSLQQPTWAENLKLAHKERASIAYSAAARGMSTLYGIGPASSERLSPYVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKMQ
Length1522
PositionKinase
OrganismOphiocordyceps sp. 'camponoti-leonardi'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.188
Instability index44.42
Isoelectric point8.62
Molecular weight166376.00
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21745
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1025.93|     242|     244|     940|    1183|       1
---------------------------------------------------------------------------
  548-  762 (236.86/147.30)	.....RLSVG.....CNTASPPA.GR..QHLI..KLL...DSTIQGHS..DRELAAKCLAVTN..DKAEL...VKTLVEWatsihrpglaklyiavslikewaasdvtsvivdlLDHVSS..SDRLRKKA.IFHLVSELIRAGLFSVSKY..VKWLIG.................R..GGLHDAAEIDPDEgpCSSR..LLVELP.IHCL..TESQRL...QRTNLLWRAG........HYSTAEEAKDIA.NALRC.VDGSL...GLSQHL.G...NTD.....AASAKCL.......................................SM
  763-  937 (151.04/90.38)	PKLLRRISNS.....SKAVQTSIGAHL.RDVLtPEL......LAKVEPvvALSTFSS..ARLVLETARDFtclSQVLKSY................................aaASDVEVL.AACADTVNsLLDVFLAMGT...ADALFSalAGRLKS.................LNREQAAAARPLLVA....LAS..LARRLPNRGSLAQ......QLQRELAQSERSKAIdaCSPVSDSMAMQAAPTGeSE...............................................................................
  940- 1182 (377.94/249.54)	.EQIDKLLAS.....GNTVDPPTMNRLfRNII.PKLE...AGWAKTDG..RRRVFASLLARLRIFDAQHF...DKLMADW..................................VSHVGTL.KDRPRLLE.LFPLLMSLGCLSIPTVLRS..ANSASS.................TDPGSASDASSIYLQE..LLQL..IVMKLPRAGCLDTVETYRFEVQQRTARLEHAGAL..LSLIRNAVAEYAAVMG.SRNDCpLDDTFCRDCLVETL.RYLVATDS....SAVAKVLDVGTLAAGAV..EFVDQMVTRLLAPDGDG......GSQESF
 1183- 1434 (260.09/162.64)	D.........qllslSNELTMPFCQL........KLDvylSGAEKSTA..RLEGFAR..AMDRAIEARNI........SW..................................TKMLPCLsQDITRSLS.MQAHARFLGL..VPS.LKS..EGEASSeqavdlaenllgvieaiTSPQSAQLTTAL.AEK..LCDLwgIIASQKEEGTTTTTTTTTTTTTTTLTEMVLDRWL..PALLRFVVLHGVCAEG.SQDDA......VRSRIILVLcGLLLELDSrprgSLSQHVLDVATLLVDGLpdEARIQCAKNILFLPGGGsvggpsGVNTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.51|      21|      21|     156|     176|       2
---------------------------------------------------------------------------
  108-  126 (30.73/16.95)	PQ...ILTPSRTAPVLAPPVSD
  133-  152 (25.48/12.50)	AQS.RGSQYDDNPPIPLPKRR.
  156-  176 (34.56/20.20)	PER.TVSTPRPSAAIVAPTKKD
  179-  200 (27.73/14.40)	PRPyTVEVPSSAPRFVSIRKND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.35|      21|      21|     433|     453|       3
---------------------------------------------------------------------------
  433-  453 (38.65/23.08)	IT.SNL.ESSPQSRMPMWILIAQ
  454-  476 (26.69/13.61)	ITwADLvRSRKYGRRLVYTLLAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.44|      10|      22|      18|      27|       4
---------------------------------------------------------------------------
   18-   27 (18.25/ 9.74)	APASHSAVQR
   42-   51 (18.19/ 9.69)	APSASPAVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.14|      16|      21|     500|     517|       5
---------------------------------------------------------------------------
  500-  517 (24.64/18.21)	LKTLLrsNPESFVAPQLW
  524-  539 (30.49/16.29)	LKAFL..PPDDGVSQDAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.11|      15|      17|     326|     342|       6
---------------------------------------------------------------------------
  326-  342 (22.89/20.27)	PHgiRGRTLLDQCLNKN
  344-  358 (27.22/16.41)	PT..ERAVWLAKCVGAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21745 with Med12 domain of Kingdom Fungi
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