<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21714

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGLMVRVAAEESYLALRELVERSRAEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCRQLASTLSVHETCFTQTADSLFFMHDGLQQARAPIYDVPFATEVLRTGSYRKLPKCIEEIGTQNMLLQDERRPTLKKLNTLVRAKLLEMPLPKEISEVSVTDGIANLRVDGEFKVLLTLGYRGHFSLWRVLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTDNPFMILYTVLHELCISLVMDTVIRQANVLRQCRWKDAIKSELISDSSAAQGGNAPVQLGQDGELDLSGFRIPGLKVHYWLDENSSGSAEPDLSPFISIEAGKDMLISCLHSTFILDPLTDKEANLSIDLRCIDVEALILKAIACNRHTRLLDIQRELSKNIQISQSPTDVVLKRGVHVEGLGKKVDGKNFENSCTDEVLQIRAYGQLYIHLGMNIRSGRLLLQSSKNILLPSALLESEEALNKGSSTAIEVFVSLRTKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLHGSDFVVMGFPQSANAYYLLIQLDNYLRPVFHLLETQTDESNNSNADANQVIRFNRIDISHMQIGEDEYSVNLFDTGKVLQDIEGRSFRPSGNGKLLPLTPSFSPSFSSLVDEVFEHNTSSSTIENQLLPPSSLPSTHLSSFQVGPEGLSGTACLPELDGNLMHSDINNSEVTPDVSLNSDPLSNSSGPARISSMSSDCKSGHGLSSLRSLGGHNIVHGSKSLQLFYSDGQEVLGNISTTKLGGPSRKRSLSEILLNTPSLQQSRISNGPRKRRKASELMKDGVLYKEYSSGKPLTYGNIFTEENHCVTSAIYASVLRHVIKHCSVCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGRMSWDVRINDPYYGSLWKVHGGSTATEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEVTSVHRLVSDLQRLSNARAFSCRMRRLIGVKVDDKRDEKVTSAGTNLLPARKGSKHRLSDQIRKIFRIEAVGLMSLWFSYVAAPMVHFVVEWESGNDGCTIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTSYSSVPKQNIFRAQGAPANDSSSTTMQNVSASLGPSAAHITQNVSAPLSPSAAHSNNHNLQSSVLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRIIYRKIFSVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFESNYMSARHSGAQLKANVNTASGSQQSAPALNRFHGAHGVAISRPTANVGNQVAPTFTRTGSAMVASSKFASGIAGAPHLSPGSNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELATSEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKIQSQAHGEIASAQRVRVELCLEKHHGSESNDHTESSSSSKSNIKHDRANRSVDFGLTFVLDQALKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVTFLAMEGSHGGRACWLQYEDWERCKQAVDLAVESANGSPATGEIGQGRLRLVAEMIHKQLQLSLQQLRNGQLSAS
Length1726
PositionTail
OrganismSetaria italica (Foxtail millet) (Panicum italicum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Cenchrinae> Setaria.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index51.08
Isoelectric point7.90
Molecular weight190064.20
Publications
PubMed=22580951

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.41|      33|      42|     670|     711|       2
---------------------------------------------------------------------------
  670-  702 (59.08/27.88)	IEN.QLLPPSSLPSTHLSSFQVGPEGLSGTA..CLP
  713-  745 (36.39/26.27)	INNsEVTPDVSLNSDPLSN.SSGPARISSMSsdC..
 1200- 1222 (30.49/10.55)	...........LQSSVLSATGRGGPGLVPSP..SLP
 1360- 1380 (26.46/ 7.72)	.............SSKFASGIAGAPHLSPGS..NLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.57|      30|      41|     118|     158|       4
---------------------------------------------------------------------------
  121-  155 (44.68/44.56)	ARAPIYDvPFATEV....LRtgsyRKLPKCIEEI....GTQNM
  160-  197 (39.89/13.53)	ERRPTLK.KLNTLVraklLE....MPLPKEISEVsvtdGIANL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.68|      34|      37|     336|     372|       5
---------------------------------------------------------------------------
  337-  371 (54.73/36.77)	DENSSGSAEP..DLsPFISIEAGKDMLISCLHSTFIL
  372-  407 (52.95/31.19)	DPLTDKEANLsiDL.RCIDVEALILKAIACNRHTRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.53|      22|      38|     746|     770|       6
---------------------------------------------------------------------------
  746-  770 (29.45/24.85)	KSGhGLSSLRSLGghNIVHGSKSLQ
  787-  808 (39.08/20.10)	KLG.GPSRKRSLS..EILLNTPSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.57|      14|      16|    1143|    1157|       8
---------------------------------------------------------------------------
 1143- 1157 (21.77/16.47)	SSVPKQNIFRAQGaP
 1162- 1175 (24.81/13.99)	SSTTMQNVSASLG.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.86|      13|      30|     415|     429|      10
---------------------------------------------------------------------------
  415-  429 (18.36/19.53)	KNIQisQSPTDVVLK
  444-  456 (24.49/17.49)	KNFE..NSCTDEVLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.03|      17|     160|     893|     915|      12
---------------------------------------------------------------------------
  877-  893 (29.69/13.01)	AQLTTQMDS..LGIPYAEE
  894-  912 (24.33/28.03)	AELGTPSSNlwLRLPFLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.25|      20|      30|      16|      35|      13
---------------------------------------------------------------------------
   16-   35 (31.15/22.00)	VRVAAE.ESYLALRELVERSR
   48-   68 (28.10/19.07)	VRLRSDtEKKIDLLKFVDRTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.90|      29|      36|     915|     946|      14
---------------------------------------------------------------------------
  915-  946 (46.99/49.31)	WkHVCLRLGKTGRMSWDVRINDPyyGSLWKVH
  954-  982 (50.91/38.15)	W.GIGVRIANTSEIDSHITFDDD..GVVLTYH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.24|      43|     134|    1304|    1346|      16
---------------------------------------------------------------------------
 1304- 1346 (73.56/47.60)	GAQLKANVNTASGSQQSAPALNRFHGAHGVAISRPTANVGNQV
 1439- 1481 (71.69/46.19)	GSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21714 with Med14 domain of Kingdom Viridiplantae
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