<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21713

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHDGLQQARAPIYDVPFATEVLRTGSYRKLPKCIEEIGTQNMLLQDERRPTLKKLNTLVRAKLLEMPLPKEISEVSVTDGIANLRVDGEFKVLLTLGYRGHFSLWRVLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTDNPFMILYTVLHELCISLVMDTVIRQANVLRQCRWKDAIKSELISDSSAAQGGNAPVQLGQDGELDLSGFRIPGLKVHYWLDENSSGSAEPDLSPFISIEAGKDMLISCLHSTFILDPLTDKEANLSIDLRCIDVEALILKAIACNRHTRLLDIQRELSKNIQISQSPTDVVLKRGVHVEGLGKKVDGKNFENSCTDEVLQIRAYGQLYIHLGMNIRSGRLLLQSSKNILLPSALLESEEALNKGSSTAIEVFVSLRTKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLHGSDFVVMGFPQSANAYYLLIQLDNYLRPVFHLLETQTDESNNSNADANQVIRFNRIDISHMQIGEDEYSVNLFDTGKVLQDIEGRSFRPSGNGKLLPLTPSFSPSFSSLVDEVFEHNTSSSTIENQLLPPSSLPSTHLSSFQVGPEGLSGTACLPELDGNLMHSDINNSEVTPDVSLNSDPLSNSSGPARISSMSSDCKSGHGLSSLRSLGGHNIVHGSKSLQLFYSDGQEVLGNISTTKLGGPSRKRSLSEILLNTPSLQQSRISNGPRKRRKASELMKDGVLYKEYSSGKPLTYGNIFTEENHCVTSAIYASVLRHVIKHCSVCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGRMSWDVRINDPYYGSLWKVHGGSTATEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEVTSVHRLVSDLQRLSNARAFSCRMRRLIGVKVDDKRDEKVTSAGTNLLPARKGSKHRLSDQIRKIFRIEAVGLMSLWFSYVAAPMVHFVVEWESGNDGCTIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTSYSSVPKQNIFRAQGAPANDSSSTTMQNVSASLGPSAAHITQNVSAPLSPSAAHSNNHNLQSSVLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRIIYRKIFSVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFESNYMSARHSGAQLKANVNTASGSQQSAPALNRFHGAHGVAISRPTANVGNQVAPTFTRTGSAMVASSKFASGIAGAPHLSPGSNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELATSEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKIQSQAHGEIASAQRVRVELCLEKHHGSESNDHTESSSSSKSNIKHDRANRSVDFGLTFVLDQALKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVTFLAMEGSHGGRACWLQYEDWERCKQAVDLAVESANGSPATGEIGQGRLRLVAEMIHKQLQLSLQQLRNGQLSAS
Length1613
PositionTail
OrganismSetaria italica (Foxtail millet) (Panicum italicum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Cenchrinae> Setaria.
Aromaticity0.07
Grand average of hydropathy-0.195
Instability index52.34
Isoelectric point7.93
Molecular weight177168.48
Publications
PubMed=22580951

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     269.38|      76|     156|    1034|    1109|       1
---------------------------------------------------------------------------
  531-  568 (27.79/10.28)	....................................................................PLTPSFSPSFSslvdevfeHNTSSSTIENQ......LLPPSSLP
 1034- 1109 (131.10/78.98)	KQNIF....RAQGAPANDSSSTTMQNVSASL........................GPSAAHITQNVSAPLSPSAAHSNN........HNLQSSVLSATGRGGPGLVPSPSLP
 1164- 1267 (110.49/65.28)	QFRPFimehVAQGLNAFESNYMSARHSGAQLkanvntasgsqqsapalnrfhgahGVAISRPTANVGNQVAPTFTRTGS........AMVASSKFASGIAGAPHLSPGSNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.12|      19|      43|     569|     611|       2
---------------------------------------------------------------------------
  569-  599 (23.27/43.45)	STHLSSfQVGPEGLSGtaclpeldgnlMHSD
  613-  631 (34.85/ 9.35)	SDPLSN.SSGPARISS...........MSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      21|      42|     177|     204|       5
---------------------------------------------------------------------------
  177-  204 (32.22/31.41)	WKDaikseliSDSS.AAQGGNAP...VQLGQD
  222-  246 (28.90/14.76)	WLD.......ENSSgSAEPDLSPfisIEAGKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.24|      34|      41|       5|      45|       7
---------------------------------------------------------------------------
    8-   42 (56.17/43.53)	ARAPIYDvPFATEVLRTGSYRKLPKCIEEI....GTQNM
   47-   84 (50.07/20.84)	ERRPTLK.KLNTLVRAKLLEMPLPKEISEVsvtdGIANL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.49|      24|      27|     677|     703|      11
---------------------------------------------------------------------------
  648-  664 (20.84/ 7.95)	......NIVHGSKSLQLF.YSDGQ
  680-  703 (39.53/29.96)	RKRSLSEILLNTPSLQQSRISNGP
  705-  727 (36.13/17.37)	KRRKASE.LMKDGVLYKEYSSGKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.42|      10|      28|     396|     405|      12
---------------------------------------------------------------------------
  396-  405 (17.61/12.01)	VSLR.TKSILH
  424-  434 (13.81/ 7.48)	VTLKiPKSVLH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21713 with Med14 domain of Kingdom Viridiplantae
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