<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21701

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAGSGPTLRRRSICSSSSHARASACFASTSSPSGASRCHLICVSGSQQNYFLSLVPLVHYCQQLGTTLSIHETCFTQTADSLFFMHEDLVKAQAPMFDVPSAIEVMLTGGYHRLPKCIEDIGSQNRLSPDEEKRALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVLRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASENPFTVLYAILHEFCISLAMDTIIRQANALRQGRWKDAIRSELISDSATGQIGNASLMQLVQDGELDSSGFKIPGLKVNYWLDEKSTSTAEPDSSPFIKIEAGQDMQIKCQHSSFVLDPFTDKEANLSLDLSCIDVEQLILRAITCNRHTRLLNIQRQLCKNVQVSQSPKDVILKRDVTAAKDPKKNAEKKGSSDCFGNEVLQVRAYGQAYISLGINIRSGRFLLQSPENILPPAALMDCEEALNKGSTSATEVFSSLRTRSILHLFAAAGRFFGLKVYQQSQGTLKIPKAILDGSDFMIMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDASDKTNANADAKEAIRFNKINVGQMQILKSESTTNPFDVKLQALQSIMSSADIMDSDLPVQNGIEPLPLLPACSPSFSSIVDEVFEYERGSTAAQNHSILPSSLPATPHLSSLSVGIQGVNARAVSPMHDGGLSHTQANNILKVHPSVSLNSYFPSNFRHLHDVNKSLQLVPSSNSNSNQIPVQSSHSGSLGNSPSDHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPIIPSLQGLQPSDPIKRRKISESARSPLPLQAYTSNLQSRASLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSNLWLTLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELNGGNTTTQWGVGIRIANTSEMDSHISFDSDGVVLTYNTVEADSVQKLVSDLRRLSNARSFACGMRRLIGVKIDDKLDDNQLSTEMKSQSVNKGNSDASDKLSDQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSSMPKQANNIPTQGPLANGSSSSSIHHAPVPSNAAAAHLSSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNAAQASGHLNNNAGAPQTAPSASRLSATPGVSLSRPTSGVANHVAASLSRAGNAMLASSALASGIGGASVRLAPGAGLPVHMKGEINTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSASADNTESTLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNNHIAFLAMDGSHGGRACWLQLEEWERCKQKVSRAVETVNVSAVAGEVGQGRLRMVAEMIQKQLQHCLQQLRDGPLSAGSTAS
Length1707
PositionTail
OrganismSetaria italica (Foxtail millet) (Panicum italicum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Cenchrinae> Setaria.
Aromaticity0.06
Grand average of hydropathy-0.134
Instability index51.76
Isoelectric point8.15
Molecular weight185572.49
Publications
PubMed=22580951

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     443.39|     146|     466|     559|     733|       1
---------------------------------------------------------------------------
  559-  714 (214.40/171.08)	DASDKTnANADAKEAIRFNKINVGQMQILKSESTTNPFDVKLQALQSIMSSADIMDSDLPV......QNGIEPLPLlpacsPSFSSIVDEVFEYERGSTAAQNHSILPSSLPATPHLSSL...SVGIQgvNARAVSPMHDGGLSHTQANNiLKVhPSVSLNSYFP
  745-  899 (228.99/176.65)	SHSGSL.GNSPSDHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPIIPSLQGLQPSDPIkrrkisESARSPLPL.....QAYTSNLQSRASLTYGDVLAERNNCVPATIYASVLLHVIrhcSLCIK..HAQLTAQMDSLAIPYVEEVG.LRT.PSSNLWLTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     375.88|     131|     404|    1099|    1240|       2
---------------------------------------------------------------------------
 1099- 1240 (209.61/141.35)	NGG.EVASFLDCIRLTagPLL....ALG.GAIRPARMPVTVSSGYssMPKQAnNIPTQGPLANGSSSSSIHHAPVPSNAAAAHLSSHNLHAA.AMLS....AAGRGGPG..LVPSSLLPFDVSVVLRgpYWI....RIIYrkkFSVDmRCFAGDQVWLQ
 1246- 1359 (133.09/67.29)	KGGpSVGGSLPCPQFR..PFImehvAQGlNALEPNFMNAAQASGH..LNNNA.GAPQTAPSASRLSATPGVSLSRPTSGVANHVAASLSRAGnAMLAssalASGIGGASvrLAPGAGLP........................................
 1604- 1645 (33.18/ 9.89)	.....................................................................................................AGG..........AAWLPYCVSVRLR..YSFgdnnHIAF...LAMD.GSHGGRACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.81|      15|      22|    1383|    1398|       3
---------------------------------------------------------------------------
 1383- 1398 (22.99/20.47)	W....VPlAALKKVLRGILK
 1404- 1422 (21.82/13.42)	WlfaqLP.ELLKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.11|      20|      22|     946|     966|       5
---------------------------------------------------------------------------
  946-  966 (31.47/27.46)	GVgIRIANTSEMDSHISFDSD
  967-  986 (33.63/23.31)	GV.VLTYNTVEADSVQKLVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.40|      16|      22|    1010|    1026|       7
---------------------------------------------------------------------------
 1010- 1026 (22.28/19.36)	DKLDDnQLSTEMKSQSV
 1035- 1050 (27.12/17.95)	DKLSD.QMRKTFRIEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.39|      48|    1405|     238|     297|       8
---------------------------------------------------------------------------
  243-  297 (66.23/77.71)	ISLAMDTIIRQANALRQGRWKDAIRSELISDsatgQIGNAslMQLVQDGELdSSG
 1656- 1703 (81.17/53.45)	VSRAVETVNVSAVAGEVGQGRLRMVAEMIQK....QLQHC..LQQLRDGPL.SAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21701 with Med14 domain of Kingdom Viridiplantae
Unable to open file!