<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21675

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTEANASSISTHYYKLAHLGSINYTIYESAVNNDQALLELELTIRHQFPEILITYYNKNLYYFTFGHNAESSIDLVKEFPQLSVNQSDTATTEQFANPLKVPNEYLTYAGLSFLKAIKKMILYNLSLQGSVKLFGNYCVSSNTDQSYSILCIDPVLFQNGDLLLSCLEKPSIRLFNSSLAYPQECAIETNYVIYLVPSGIRCHLFDATSLRNNLVEKPQVENEKLLELLKLTTGVDCNMSNLWVKLIPNLKHLNNQTSFIGKFIHSVDNKKFILWPWELCLLQFGKFENLQQEVISDTPDINNPLNLISDFLDFLISYNTQLQHQKLLEQEQQQQQEQQLLLQVQQQSQLQQMTHAPFSVGSAHSNSGIGSIAEMPKDIGSIGMSATTPMDADLFNLQNTEEFFKTDHDHLQSGDQEGAEQKVEQLDEDDMEIDDLFGGDDSDDESKNENKETVASSAKVETDDLDDLFADGSPSEEPPEEHQSDQPKAEPLPPTPAKEAENDKENLKPKEVKPSYIDILRDQMTIKKMDSSPDYKDPGAPLPIVPTPLVLSTVTQSAGPTNPPTVGPYEASYDNSSNNTSNVYGQSAPPLQMPQQKSVFSPILFNPIIKSDIDTKYGKGGKFYVDKESAKDIDFETKKRTLRATSVSGMELSFSTDDKKKLQQQLDAIESSTTSSGLEEELDEDDDDEDEESDEDEEPDIGDSTPLKLNTYNESMAYLQSNNPATVNNITTDGQEFQNNGMEKPAFANTSLNADGFGSPFASQINKFTMKPESPFSTNEIQTSMSPMYFEPSQSQQSPQLQPSVGNTENKSGILDSPSKISESSNYLPLLLRNINIASVPTVYLMNNLTSSKLLPTFSINDDDLENDLDITKSNEMIVRLEYLREFLSFITPNIVFDLGATNFDNFDYYMNNVKDVSDGAKELRLPSETFFKSLSKVFPYMYPVKLIELLHDAKTLELEDPLDNQLNFLNDVANEDESFADPKTLYKKLKSLEWDSFDLSNQNKAKFEKYKDTIEKLNAGNTINDDDYFKLPVVKTRVLKNNNIVNLNNVGLDFWKYLNFAPVKKPKNFQILLIAETQGISSSYASEFLDQLVQNYKESNFGTISKVNLSTVETRADLDPISDGLVLINKDPNQLYNDFYIQTNKKLISLVELIKLDLINKTNNFEFDRPLLLFFVNFNESLNSSLQICKIFRNFKVALMSHQLPLVEIFTKIAPSSLLVKKVNHESTLRVFNNHKLTKISMNLYNECPNDLANKTIAKNVFTNIVKEPPSKIQFKFINNSYRDNGFNDDIFLHLAYERSIDKNWFVASWSDPLGQVVHTKSWYCSTNSSGSVTGQQRPNYRNDAMDIMAITDDMWNISTELFKFLNDEMNLAGGSTFGGKKFLVLTRVNSIIPDDELIHWKRLSLKHKEISLIVLSVCQTPKVVNSSELKEVTSKSGASTSPMSMSHEKDAFFNFKTGFSISNNSSPASGGVLVTSPNGLSFHSPQQFLNAPANFLSPQDLTPGGTASGGMEIDPDMVLHHLDDDVYGVVPRLPLPSFNSPTRFCMKTGYLMMNIDDAVDEENGDATEETKKKSYLLFEINILSCSNYWNLDVLMRLLMLQYKKMIVLNNILCMESIDSKFEDSKNQERSSQIIPWHVNAVGKLLNYLVHIYVDEE
Length1658
PositionKinase
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.448
Instability index46.44
Isoelectric point4.70
Molecular weight187092.00
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21675
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.51|      19|      29|     434|     452|       1
---------------------------------------------------------------------------
  409-  432 (23.61/ 9.98)	DHLQSGDQEGAEQKveqldEDD...ME
  434-  452 (33.11/17.26)	DDLFGGDDSDDESK.....NEN...KE
  466-  483 (29.10/14.19)	DDLFA.DGSPSEEP.....PEE...HQ
  490-  511 (21.70/ 8.52)	EPLPPTPAKEAEND.....KENlkpKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.42|      14|      29|     645|     658|       2
---------------------------------------------------------------------------
  645-  658 (24.58/12.64)	TSVSGMELSFSTDD
  673-  686 (23.84/12.06)	TTSSGLEEELDEDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     340.30|      52|      53|     929|     980|       3
---------------------------------------------------------------------------
  841-  878 (32.24/11.84)	...........PTVY...LMNNLTSSKLLPTfsinDD.DLE..NDL....DITKSNEMI
  882-  924 (55.94/26.05)	EYLREFLS....FITP....NIVFDLGATNF.....D.NFD..YYMNNVKDVSDGAKEL
  929-  980 (80.89/41.02)	ETFFKSLSKVFPYMYPVKLIELLHDAKTLEL....ED.PLD..NQLNFLNDVANEDESF
  984- 1027 (50.39/22.72)	KTLYKKLKSLEWDSFD...LSNQNKAKFEKY....KD.TIE...KLNAGNTI.NDD...
 1029- 1070 (36.33/14.29)	..YFK.........LPVVKTRVLKNNNIVNL....NNvGLDfwKYLNFAP..VKKPKNF
 1099- 1135 (41.14/17.18)	ESNFGTISKV.....NLSTVETRADL..........D.PIS..DGLVLIN..KDPNQ..
 1139- 1178 (43.37/18.51)	DFYIQTNKKLISLVELIKL.DLINKTNNFEF....DR.PL....LLFFVN.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.42|      27|      31|    1222|    1252|       4
---------------------------------------------------------------------------
 1222- 1252 (43.34/33.23)	KKVNHEstlrVFNN...HKLTKISMNLYNECPND
 1256- 1285 (42.09/23.28)	KTIAKN....VFTNivkEPPSKIQFKFINNSYRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.27|      24|      45|     241|     264|       5
---------------------------------------------------------------------------
  241-  264 (42.50/27.18)	NLWVKLIPNLKHLNNQTSFIGKFI
  289-  312 (40.76/25.72)	NLQQEVISDTPDINNPLNLISDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.75|      36|      51|     530|     569|       6
---------------------------------------------------------------------------
  530-  565 (67.75/36.51)	DSSPDYKDPGAPL..........PIVPTPLVLSTVTQSAG...PTNPPT
  579-  618 (35.85/18.66)	NTSNVYGQSAPPLqmpqqksvfsPILFNPIIKSDIDTKYG.........
  696-  726 (43.15/18.75)	DEEPDIGD..................STPLKLNTYNESMAylqSNNPAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.19|      32|      36|    1438|    1473|       7
---------------------------------------------------------------------------
 1442- 1473 (60.24/33.12)	TSPMSMS.HEKDAFFNFKTGFSISNNSSP...ASGG
 1477- 1512 (50.95/20.18)	TSPNGLSfHSPQQFLNAPANFLSPQDLTPggtASGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.24|      28|      38|     156|     183|       8
---------------------------------------------------------------------------
  120-  149 (18.54/ 7.51)	......MILYNLSlQGSVKLFgnycvssNTDQSYSI
  156-  183 (49.29/35.05)	LFQNGDLLLSCLE.KPSIRLF.......NSSLAYPQ
  204-  220 (18.41/ 7.40)	LFDATSLRNNLVE.KPQV..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.44|      33|      40|     727|     760|       9
---------------------------------------------------------------------------
  727-  760 (55.81/41.06)	VNNITTDGQ.EFQNNGME...................KPAFANTSlNADG.FGSP
  765-  818 (39.63/23.18)	INKFTMKPEsPFSTNEIQtsmspmyfepsqsqqspqlQPSVGNTE.NKSGiLDSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21675 with Med13 domain of Kingdom Fungi
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