<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21673

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDKELVNRHLLDVTRTSDLIAWSRNGFIAYIPPTPTSKSNMLLTYLENVNGVTWQLSKPLPINVKVDNSVNFLPQLSLVSWSTLSTDLAISDIYGNFYILLAGVRMLESKDTTSPSFELTSYNHMEMIYRDIINDDINSPVNPGALVIAYKWLNIEKTQVWNKPATRVNLDTPSNDGNSFIYAYGVNQHQAHGVCHPIPTKQAVLVLRKNGQLMLYYQGEHKVEYHKIFENLTEEFQIIKKASIGFTNDKKVIITTWDSLTNNINTYAVEINWGFLTESAKRQKVDAHYHTPKEAQKPPKLIIKKIHQMKPLECYHEGEKEGGHLDVTGLTSIDLISANPEQNSSLSILITYDSSVIYRYTLDTSVVSDVFTNLGLEKNAQCQGKESITVTLVDKMTRGGPIESISSGFLDYTFSILYKDGRVEVVDTRTFKIQNIEKEDTKPNHITSIFDIGFEVPKVEHVKPLIMAVSPNLTAVVYTELFADTLNLKLEMFKRTRNLGLLKGDLYTTAVGLAYCHALALYSSSGSDDLVVLMQIEAQRLRSSLAATDQKDVEAEVKKFIGTLTTECHKAINFQIDSYSKDAIDRLLSTNTSLQKLLSLLFILGEVQQNHKAADISLIVLHLKSTSLGIMFSLSNIYRQISKKKPSEDTLQDSINRGEYIVSLLGSFKWLIDLLAYLNQELLQLTYIKNNNLKNSKLTLKNSIAIPILMGKVPRLFLMYAITSMGRTHEILKKVLKELTDANKLFTPMKESLNRYFAICNTAPVTVNLFENFLRECDALCTKELATRFTSKEQALRFEQKLVCQGELPDEFLDVALSLLDRFTMNSSREMKVAELVLYPTEWLDIGVMRKKTWIDPSKILNDAPQKVILRWDFEGGHIDSLRKIYMDDDFARAAASNNGLRQCTRCRGISAVTDNNVFEVQTPAGLWTMLFQRNCLCGNPWITDLSI
Length948
PositionTail
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.163
Instability index30.01
Isoelectric point6.72
Molecular weight107321.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21673
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.76|      53|      84|     584|     639|       1
---------------------------------------------------------------------------
  584-  639 (81.36/57.75)	IDRLLSTNtslQKLLSLLFILGEVQQNHK...AADISLIVLHLKSTSLGIMFSLSNIYR
  672-  727 (84.40/52.77)	IDLLAYLN...QELLQLTYIKNNNLKNSKltlKNSIAIPILMGKVPRLFLMYAITSMGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.52|      23|     516|     131|     153|       6
---------------------------------------------------------------------------
  131-  153 (41.74/26.95)	DIINDDINSPVNPGALVIAYKWL
  649-  671 (40.78/26.17)	DTLQDSINRGEYIVSLLGSFKWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.31|      19|     553|     371|     389|       9
---------------------------------------------------------------------------
  371-  389 (33.76/22.30)	FTNLGLEKNAQCQGKESIT
  898-  914 (24.91/14.50)	..NNGLRQCTRCRGISAVT
  928-  944 (35.64/23.96)	WTML.FQRNCLC.GNPWIT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21673 with Med16 domain of Kingdom Fungi
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