<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21671

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQHANGSPNGKLEASSSSLIPDIPHITANILPLSNIIKFYTQEAYKQLTTAVENLSMNIEEESDIKRKKYFLDIIISLRQDFIKVYTLIKWASISKDVSKFIDLLNWFRLQEFQFENLMFQLNALTGYSGAKLPNSDIITALEVLYNGRPTLPSYNHIKIKNLSLGKILEVLEDLNLVLMTRFALMDIPKKFQYEIKDGRVYINVPNEYQVSITVGNDLIIDNKEDYYKSPFYFIDFKFLFGINPETAMITYHDDKVFTKLPSSLHAKLEKIANQVLLKEGLEGLYDLLHRYSTSFKIYLIAKQFKELFNTRWRNNFQINYQTGKSLIIVNYWSLHYLSKNWKSFLELGIDRNSNLSYRWFKNGQYSVDQELNKIFHIIPQDELNDINDDEVDEEPYSDDLNVDLILNVVVNKHAELLMTQIYQKLLEKFGDDEVSTVTPHQLLLQISPNKSTVFAINPLTGFFYFIDPTPVQNQITKKINLPPPITKPFVTEADMVSHIIDQITQLRLEVFNKEINNKLATTEWINNGIIKLGDYELSKLTNFLLDYEEVVGVTKVQFYRRKNWPSSWFLINMVSGLTTKSFWWVARIKSISGDWKIQWVQIIKFKEEDEENLLGVDPEELNYKFFNELSTFSSNMIIDHMVLEELNLRKVKFLKIKKGEKEVLEKFKLHVPGESKVDSNGGTSSLGVHYESMLLIHNHDLLPIYNSSSSLFLKIQLIGKNQMYLKLFGNLRNLKIKNSEEYELKLHLKIDEVNNFFQIDNTVNLLTVINESRNNLLDLIFNTLNKLNELIKILDQLNKNKITILDNDMDNITIKVSNDINNLVIKLPEQADHSIQLVSKDETPWEIQLVLKYLNQYLQEHRSSNILGIIKYLHEINPIINSEKLIADQIDSTNKTYMKLANGLNKLNFDLVFFNLNHLQFIYFINSNISNMKKIQKDKIIINISFKSLRFDDKKRKLIKVSLKDNLNPKNMKFKKLFEIMFKNINELIVNKGAKKPQPAAVTSTIEDDLINFDVDESEPEEEPKDEQQVFIKLNYDYLVTKDNFGPIMNEITKSFIQYLQE
Length1064
PositionTail
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.11
Grand average of hydropathy-0.288
Instability index31.00
Isoelectric point5.99
Molecular weight124203.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21671
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     396.94|      75|     130|     716|     790|       1
---------------------------------------------------------------------------
  598-  641 (43.54/18.48)	...............KI.QWV...QI................IKFKEE...DEENL.L....GVDpeELNyKFF....................NELSTF..SSNMI.ID........
  642-  712 (31.64/11.31)	........................HMVLEE.L.NLRKvkfLKIKKGEKevlEKFKLHVpgesKVD..SNG.GTS.....SLGvhyesmlliHNHDLLPIYNSSSS.............
  716-  788 (114.36/61.12)	...............KI.QLIGKNQMYLKL.FGNLRN...LKIKNSEE...YELKLHL....KID..EVN.NFF.....QID.........NTVNLLTVINESRNNL.LDLIFNTLNK
  789-  858 (83.68/42.65)	LN..........eliKIlDQLNKNKITI.L.DNDMDN...ITIKVSND...IN.NLVI....KLP..E...........QAD.........HSIQLVSK.DETPWE..IQLVLKYLNQ
  859-  920 (60.55/28.72)	..........................YLQ....EHRS...SNILGIIK...Y...LH.....EIN..PII.NSEkliadQID.........STNKTYMKLANGLNKLnFDLVFFNLNH
  921-  989 (63.18/30.30)	LQfiyfinsnisnmkKI.Q...KDKIIINIsFKSLR......FDDKKR...KLIKVSL....K..............................DN.LNPKNMKFKKL.FEIMFKNINE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     387.07|     103|     107|     153|     259|       2
---------------------------------------------------------------------------
  153-  239 (137.16/76.54)	...........................................LPSYNHIKIKNLS....LGKILEVLEDLNLVLMTRFALM..DIPKKFQYEIKDGRVYINVPNEYQVSITVGNDLIIDNKEDYYK.SP....FYFIDFK
  240-  344 (137.84/88.97)	FL.FGINPETAMiTYhddKVF....................tkLPSSLHAKLEKIAnqvlLKEGLEGLYDLLHRYSTSFKIY..LIAKQFK.ELFNTRW....RNNFQINYQTGKSLIIVN...YWS.LH....YLSKNWK
  346-  469 (112.07/61.96)	FLeLGIDRNSNL.SY...RWFkngqysvdqelnkifhiipqdeLNDINDDEVDEEP....YSDDLNVDLILNVVVNKHAELLmtQIYQKLLEKFGDDEVSTVTPHQLLLQISP.......NKSTVFAiNPltgfFYFID..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.94|      15|      15|      78|      92|       3
---------------------------------------------------------------------------
   78-   92 (26.84/17.56)	SLRQDFIKVYTLIKW
   94-  108 (26.10/16.85)	SISKDVSKFIDLLNW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21671 with Med14 domain of Kingdom Fungi
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