<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21664

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMADETLSLSKLLEKAVTQKLQPKLFISLFNQLGKRKPIQPNELVSELLNIKPDNNSLKQRKWNEYQVNVVIELSFSSVENNHLFWTNLDLANESSQCTYLLKLSRTLTGPQHYEKDVLKNFISVEFMDYVLKHIRGEKFSDKVVEHIVFLFAVIVQKFDKFIEEKTSGAVLDFIVNFIRILRSLTGNDNLSSVLLLKSKKILSKAQIEQLESTRHAKMERQGSIISLSPNVQANVASLTMINKLDEFYFRMRYIWVHKTFRHFNFNDTLNFFVNNLVAAPNQKNSYLIAHDFIKALLSGLDMDGYALFNVKNFLLTRAPHLLGNLRYGEDNLEKAVNDALQNVEIDNDFKQRFVKAFDFPDEPMLQFRDKFNDKLLNVNSEFTSLEESGLVELVNALPKLCQLSKTQQEVTQVILDIVDELGYSRDFEKLNRLLLTAMNNVELVNIVLFNSNLSLLYKLLDLIDSSNFRIHDDDENFQDHYSYCGIIMLSILTIVQNFQIDLSEVTVKDSFIINYLNEFYYRSCDNLTNATPVNSDEEDKIIVENYQNLLNEWITALFDDKNEGLSDDLIKSLSIKQIYKLVPLIYKQGIVAADLNKIDWGILSNGLEYLSQPFLTPIVPIIIKSLVRDCNIDFGLKLRIIKEMINDTSNPITKLVISICGNDIIKLNPPVELKEHVQQNVHYVDVAEPFPRDYNVKDAFRSQLLGETSLLSKFITTYVLGNRGDVVNSLIQEIYNFQKSNHEDSKMFINLMVFIVLLDSIETRQDRDYWKRELPSSCKTTVQKSSEPFFEASMDHHYSSIFNDPSSNSSFGQQQDGLDGMNDFLKGVGGDDDDQMMQDDDLFNEKPKTSDQLQNLLQKAQHHLCLINQFRKKRGDLLNNALFGKSVSLLNDKLVEEMTNWRF
Length903
PositionTail
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.248
Instability index30.52
Isoelectric point5.27
Molecular weight104178.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21664
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     265.20|      84|     121|     127|     211|       1
---------------------------------------------------------------------------
  127-  207 (117.38/64.46)	...........................................MDY..VLKH.................................IRGEKFSDKV...............VEHIVFLFAVIVQKFDKFIE.EKTSGAVLDFIVNFIRILrSLTGN....D..NLSSVLLLKSKKILSKAQI
  208-  327 (103.80/53.10)	EQLEstrhakmerqgsiislspnvqanvasltminkldefyfrMRYiwVHKT.................................FRHFNFNDTL...............NFFVNNLVAAPNQKNSYLIA.H.......DFIKALLSGL.DMDGY....AlfNVKNFLLTRAPHLLGNLRY
  330-  436 (44.02/18.88)	DNLE................................................kavndalqnveidndfkqrfvkafdfpdepmlqFR.DKFNDKLlnvnseftsleesglVELVNAL........PKLCQlSKTQQEVTQVILDIVDEL....GYsrdfE..KLNRLLLT...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.93|      28|     270|     223|     250|       2
---------------------------------------------------------------------------
  223-  250 (49.15/33.84)	SIISLSPNVQANVASLT.....MINKLDEFYFR
  490-  522 (43.78/29.27)	SILTIVQNFQIDLSEVTvkdsfIINYLNEFYYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.26|      29|      35|     582|     613|       5
---------------------------------------------------------------------------
  582-  613 (43.81/42.56)	VPLIYKQgiVAADLNkIDWG....ILSNGLEYLSQP
  619-  651 (47.45/33.08)	VPIIIKS..LVRDCN.IDFGlklrIIKEMINDTSNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      15|     427|     442|     456|       9
---------------------------------------------------------------------------
  442-  456 (24.67/13.83)	ELVNIVLFNSNLSLL
  876-  890 (25.01/14.13)	DLLNNALFGKSVSLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21664 with Med5 domain of Kingdom Fungi
Unable to open file!