<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21652

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTEANASSISTHYYKLAHLGSINYIIYESAVNNDQALLELELTIRHQFPEILITYYNKNLYYFTFGHNAESSIDLVKEFPQLSVKQSDTATTEKFANPLKVPNEYLTYAGLSFLKAIKKMILYNLSLQGSVKLFGNYCVLSNNDQSYSILCIDPVLFQNGDLLLSCLEKPSIRLFNSSLAYPQECAIETNYVIYLVPSGIRCHLFDATSLRNNLVEKPQVENEKLLELLKLTTGVDCNMSNLWVKLIPNLKHLNNQTSFIGKFIHSVDNKKFILWPWELCLLQFGKFENLQQEVISDTPDINNPLNLISDFLDFLISYNTQLQHQKLLEQEQQQQQELLLQSQQQNQLQQMTHAPFSVGSAHSNSGIGSIAEMPKDIGSIGMSATTPMDADLFNLQNTEEFFKTDHDHLQSGDQEGTEQKVEQLDEDDMEIDDLFGGDDSDDESKNENTEIVISSAKVETDDLDDLFADGSHSEEPREEQQSDQPKAEPLPPTPAKEAENDKENLKPKEVKPSYIDILRDQMTIKKMDSSPDYKDPGAPLPIVPTPLVLSTVTQSAGPTNPPTVGPYEASYDSSSNNTSNVYGQSAPPLQMPQQKSVFSPILFNPIIKSDIDTKYGKGGKFYVDKESAKDIDFETKKRTLRATSVSGMELSFSTDDKKKLQQQFDAIESSTTSSVLQEELDEDEDDEDEESDEDEEPDIGDSTPLKLNTYNESMAYLQSNNPATVNNIVTGGQEFQNNGMEKPAFANASLNADGFGSPFASQINKFTMKPESPFSANEIQTSMSPMYFEPSQSQQSPQLQPSVGNTENKSGILDSPSKISESSNYLPLLLRNINIASVPTLFLMNNLTSSKLLPTFSINDDDLENDLDITKSNEMIVKLEYLREFLSFITPNIVFDLGATNFDNFDYYMSNVKDVSDGAKELRLPSETFFKSLSKVFPYMYPVKLIELLHDAKTLELEDPLDNQLNFLNDVENEDESFADPKTLYKKLKSLEWDSFDLSNQNKTKFEKYKDTIEKLNAGNTINDDDYFKLPVVKIRVLKNNNIVNLNNVGLDFWKYLNFAPVKKPKNFQILLIAETQGISSSYASEFLDQLVQNYKESNFGTISKVNLSTVETRTDLDPISDGLVLINKDLNQLYNDFYIQTNKKLISLVELIKLDLINKTNNFEFDRPLLLFFVNFNESLNSSLQICKIFRNFKVALMSHQLPLVEIFTKIAPSSLLVKKVNHESTLRVFNNHRLTKISMNLYNECPNDLANKTIAKNVFTNIVKEPPSMIQFKFINNSYRDNGFNDDIFLHLAYERSIDKNWFVASWSDPLGQVVHTKSWYCSTNSSGSMTGQQRPNYRNDAMDIMAITDDMWNISTELFKFLNDEMNLAGGSTFGGKKFLVLTRVNSIIPDDELIHWKRLSLKHKEISLIVLSVCQTPKVVSSSELKEITSKSGASTSPMSMSHEKDAFFNFKTGFSISSNSSPASGGALVTSPNGLSFHSPQQFLNAPANFLSPQDLTPGGTASGGIEIDPDMVLHHLDDDVHGFVPRLPLPSFNSPTRFCMKTGYLMMNIDDAVEEENGDGSEETKKKSYLLFEINILSCSNYWNLDVLMRLLMLQYKKMIVLNDILCMESIDSEFEDSKNLERSSQIIPWHVNAVGKLLNYLVHIYVDEE
Length1656
PositionKinase
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.421
Instability index47.53
Isoelectric point4.71
Molecular weight187066.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      27|      29|     415|     443|       1
---------------------------------------------------------------------------
  415-  443 (41.91/29.48)	EGTEQKVE..QLDEDDMeiDDLFGGDDSDDE
  447-  475 (40.02/22.11)	ENTEIVISsaKVETDDL..DDLFADGSHSEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.88|      28|      30|     905|     933|       3
---------------------------------------------------------------------------
  905-  924 (23.48/ 9.07)	..........................FDY.YMSNVKDVSDGA.....KELRL
  925-  957 (30.77/19.21)	PsETFFKSL..............skvFPYmYPVKLIELLHDA.....KTLEL
  960-  980 (28.54/13.11)	P.........................LDN.QLNFLNDVENED.....ESFAD
  981- 1030 (26.08/11.29)	P.KTLYKKLkslewdsfdlsnqnktkFEK.YKDTIEKLNAGNtinddDYFKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     219.72|      49|      50|     185|     234|       4
---------------------------------------------------------------------------
  138-  182 (72.46/40.89)	CVLSNNDQSYSILC.IDPVLFQNGDLLLSCLEKPSI...RLF....N.SSLAYP
  185-  234 (76.59/48.08)	CAIETNYVIYLVPSgIRCHLFDATSLRNNLVEKPQVENEKLL....ELLKLTTG
  237-  285 (70.67/39.69)	CNM.SNLWVKLIPN.LK.HLNNQTSFIGKFIH..SVDNKKFIlwpwELCLLQFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.88|      32|      38|    1440|    1471|       5
---------------------------------------------------------------------------
 1440- 1471 (59.91/34.31)	TSPMSMS.HEKDAFFNFKTGFSISSNSSP...ASGG
 1475- 1510 (50.97/27.99)	TSPNGLSfHSPQQFLNAPANFLSPQDLTPggtASGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.43|      31|      31|    1201|    1231|       7
---------------------------------------------------------------------------
 1169- 1206 (19.07/ 8.50)	..........P..LLLFFVNFneslNSSLQICkifrnfkvalmsHQLPLV
 1207- 1239 (47.99/35.20)	EIFTKIA...PSSLLVKKVNH....ESTLRVF..........nnHRLTKI
 1259- 1278 (16.37/ 6.02)	NVFTNIVkepPSMIQFKFIN..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.88|      43|     170|     672|     737|       8
---------------------------------------------------------------------------
  692-  737 (67.43/75.37)	DEDEEPDIgDSTplKLNTYNESMAYLQSNNPATVNNIV..TGGQEFQN
  860-  904 (69.45/32.48)	DDDLENDL.DIT..KSNEMIVKLEYLREFLSFITPNIVfdLGATNFDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.68|       9|      51|     485|     494|       9
---------------------------------------------------------------------------
  485-  494 (17.35/13.15)	PKAePLP..PTP
  536-  546 (17.33/ 7.75)	PGA.PLPivPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.44|      14|      30|     644|     657|      11
---------------------------------------------------------------------------
  644-  657 (24.05/14.77)	SVSGMELSFSTDDK
  674-  687 (23.39/14.14)	SVLQEELDEDEDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.02|      25|      41|    1090|    1120|      13
---------------------------------------------------------------------------
 1090- 1120 (37.46/40.39)	QLVQN.YKESNFGTISKVNLstvetrTDLDPI
 1133- 1158 (37.56/25.53)	QLYNDfYIQTNKKLISLVEL......IKLDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.34|      30|     170|     576|     615|      15
---------------------------------------------------------------------------
  576-  605 (55.56/22.21)	NNTSNVYGQSAPPLQMPQQKSVF.....SPILFNP
  747-  778 (39.18/12.11)	NASLNADGFGSP...FASQINKFtmkpeSPFSANE
  788-  816 (41.60/26.10)	FEPSQ..SQQSPQLQ.PSVGNTE...nkSGILDSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21652 with Med13 domain of Kingdom Fungi
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