<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21649

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSTKSRNRNSLLSSHSRSSYSNSSTKDEILAMKYLMQEPDLPIYPLSDHARKSSSASSTTNVTDTKTHTLQDQVEPAYPDFMPWKDHTQLSAEQQEKEHQKLNNASYLNKGYFETPQVANEYYSARNLILATVFLSNDNCNTVVKELSAYLTNAYKTRNEVINKIRGDSNHFKIPNRVTLTSNKKEAWLKELSNCSIPLQKIGEKIPHGLRNKVLIDAVCSRGVPINRSIWLTKCVLYGELISLRRKHQNRMSVSGTIPQISDFNTLEKFEIHWLQEWTQQVADYVLKFSREMAAINSIEKKAQYLRKFNYLINYVKSLYVESLLDKSFFLSLVLRFLKDGLPLQHKHVGELLSASAYDSNRSMSSNNDGEDGGDDDNDDDDDLKARQGSWLNDVEMNYGQRLAALTLIKIFWNDLIKVDYLSKELSELLLLNYFFIDRWATSSSTPASYEKFALPDGLRFKLLKLISDTVKYLFEFNCNIFIIPNYWMLIESSLVKIMLSPFQKGGSEKEHEEILKQLELIKYRNESLILNMKNEANVTVESNRMANRSSSFSGFNSTAVSPAPSANVDNDYTFINRNSDDILNIIEKLDTLKFNEEFSNLLKPGRKGNKNWRLNLKVVLYWCVSPSRAYRDSIGDILFICNFLRNNVLAGLNKALKTEFDNEILEIIYQIAEDTNLNFVNSNLYVLINELYQLKLITIAAYLRKLIASGIFYLEPGTHQDLNNLPPVARTHLEILENLPVLNNRQCDSILKKWTPSGFDFKGKFTNGQAMLKKSIIDPIFNNSLSHHENVECTNHIRSLNVGLQFLLINWLTSEIKSTGSSATRLIHFTPAVVTNLYRFYSQTAGLTVFFKVIIPTILKNDGGMIIFYLDTLFLISKLTVRHFKLIKFIAGTHESGCTAYDIFKLIIQAYKDLSTRECDYFKFDHLWNFMDAVTEKAPESMDSNANGGYHNNEQPLNKHSSSLVGKDSLESPMHINTVEVPTTRLHTETRSASKRYTSTDFRNDIAYLRGSVPQSLSSEDAQEVRGAFDTDFSGSELQYWYDNFESLSEEKETGLVKLLRSIMVSDHAFSTKIKDFIVELVKTSTDFQRITTFLKKMSIYDIVRMHELVKILLPVCSELGQESIIDEIILGTEDSETKELTGSQQVLLQLNRHFYRVRSIKPYTMIILRGLLKGGAAYSNDFFFKYKYPVLRFLNLAIATNTKVILSELYVKLPRDDCLELLNIQLGRTEDNFIKTLSDFEKFALEIDEYNLPVCQVLLGVISNSLVSLDFVIVKEQLEHFIGVLLTSMNLRFSDNNSFFGELFSLMVWSHKVCILELLETKFLTETKFDNGIELFVTPTSQQNLLPPLNDFFKKFATSSSSSANSVASDKSLLQRLSDFINKLVEVVNSEAITEPTPNISSAISVFLRILIIHKLSLCEYISSWTTDELVISFVSKLIELLNSNYLSNNADKLRILLYDLLLLMKSGITQEIHSSRDTELSDTTSPQTQPHQPLKQQPQHQDKDDHSEGTSPKSKDSKIENASMVSLIQNLFDLPEPSTANPFSAYLNDGLVKCSIMLDNNELEHGGDISVFNNRGLVLKSTRNDNPELPPFEQNNLMKSKLKQLKEFKFKSFEVLEDIGANSLNDGCLNLQLFDAYTTRENPP
Length1647
PositionKinase
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.279
Instability index39.76
Isoelectric point6.01
Molecular weight188003.98
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.13|      22|      25|    1410|    1434|       1
---------------------------------------------------------------------------
 1410- 1434 (26.70/26.12)	LRILIihKLSLCEYISSwTTDELVI
 1437- 1458 (35.43/19.68)	VSKLI..ELLNSNYLSN.NADKLRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.58|      20|      25|    1547|    1566|       2
---------------------------------------------------------------------------
 1547- 1566 (36.54/23.61)	SAYLNDGLVKCSIMLDNNEL
 1573- 1592 (36.03/23.17)	SVFNNRGLVLKSTRNDNPEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.08|      24|      25|    1343|    1366|       3
---------------------------------------------------------------------------
  430-  448 (22.68/ 9.87)	....LL..LNYFFiDRWATSSSTPA
 1343- 1366 (42.42/25.22)	SQQNLLPPLNDFF.KKFATSSSSSA
 1371- 1394 (35.99/20.23)	SDKSLLQRLSDFI.NKLVEVVNSEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.76|      19|      25|    1473|    1492|       5
---------------------------------------------------------------------------
 1473- 1492 (29.05/21.72)	QEIHSSRDtELSDTTSPQTQ
 1500- 1518 (35.71/22.20)	QPQHQDKD.DHSEGTSPKSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.59|      27|      29|     982|    1009|       6
---------------------------------------------------------------------------
  982- 1009 (42.27/29.38)	VPTTrLHTETRSASKRYTSTDFR.NDIAY
 1014- 1041 (41.32/23.99)	VPQS.LSSEDAQEVRGAFDTDFSgSELQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      31|      31|      15|      45|       7
---------------------------------------------------------------------------
   15-   45 (56.22/30.23)	HSRSSYSNSSTKDEILAMKYLMQEPDLPIYP
   49-   79 (53.96/28.76)	HARKSSSASSTTNVTDTKTHTLQDQVEPAYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      12|      25|    1261|    1273|       8
---------------------------------------------------------------------------
 1261- 1273 (15.84/12.32)	LGVISNSLvSLDF
 1284- 1295 (20.96/11.60)	IGVLLTSM.NLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.78|      21|      26|     879|     903|      10
---------------------------------------------------------------------------
  879-  903 (32.63/28.46)	KLTVRHFKLIkfiaGTHESGCTAYD
  906-  926 (37.15/22.12)	KLIIQAYKDL....STRECDYFKFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.89|      15|      26|    1193|    1207|      11
---------------------------------------------------------------------------
 1193- 1207 (22.79/11.92)	LRFLNLAIA.TNTKVI
 1221- 1236 (20.68/10.13)	LELLNIQLGrTEDNFI
 1318- 1331 (18.42/ 8.23)	LELLETKFL.TETKF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.95|      22|      26|     453|     478|      12
---------------------------------------------------------------------------
  453-  478 (28.89/25.13)	FALPDglrFKLLkLISDTVK.YLFEFN
  482-  504 (37.06/19.07)	FIIPN...YWML.IESSLVKiMLSPFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.24|      14|      29|     537|     551|      13
---------------------------------------------------------------------------
  537-  551 (19.70/16.36)	ANVTvESNRMANRSS
  567-  580 (25.54/16.29)	ANVD.NDYTFINRNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.16|      33|     121|     616|     692|      14
---------------------------------------------------------------------------
  140-  172 (59.09/21.89)	CNTVVKELSAYLTNAYKTR..N...EVINKIRGDSN.HF
  642-  680 (44.07/11.83)	CNFLRNNVLAGLNKALKTEfdNeilEIIYQIAEDTNlNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      16|      25|     391|     406|      17
---------------------------------------------------------------------------
  391-  406 (28.52/20.27)	WLNDVEMNY.GQRLAAL
  413-  429 (22.85/14.58)	WNDLIKVDYlSKELSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.33|      20|      37|     192|     213|      22
---------------------------------------------------------------------------
  192-  213 (30.19/27.79)	LSNCSIPLQK.........IGEKIphGLRNK
  219-  247 (28.14/17.14)	VCSRGVPINRsiwltkcvlYGELI..SLRRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21649 with Med12 domain of Kingdom Fungi
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