<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21649

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSTKSRNRNSLLSSHSRSSYSNSSTKDEILAMKYLMQEPDLPIYPLSDHARKSSSASSTTNVTDTKTHTLQDQVEPAYPDFMPWKDHTQLSAEQQEKEHQKLNNASYLNKGYFETPQVANEYYSARNLILATVFLSNDNCNTVVKELSAYLTNAYKTRNEVINKIRGDSNHFKIPNRVTLTSNKKEAWLKELSNCSIPLQKIGEKIPHGLRNKVLIDAVCSRGVPINRSIWLTKCVLYGELISLRRKHQNRMSVSGTIPQISDFNTLEKFEIHWLQEWTQQVADYVLKFSREMAAINSIEKKAQYLRKFNYLINYVKSLYVESLLDKSFFLSLVLRFLKDGLPLQHKHVGELLSASAYDSNRSMSSNNDGEDGGDDDNDDDDDLKARQGSWLNDVEMNYGQRLAALTLIKIFWNDLIKVDYLSKELSELLLLNYFFIDRWATSSSTPASYEKFALPDGLRFKLLKLISDTVKYLFEFNCNIFIIPNYWMLIESSLVKIMLSPFQKGGSEKEHEEILKQLELIKYRNESLILNMKNEANVTVESNRMANRSSSFSGFNSTAVSPAPSANVDNDYTFINRNSDDILNIIEKLDTLKFNEEFSNLLKPGRKGNKNWRLNLKVVLYWCVSPSRAYRDSIGDILFICNFLRNNVLAGLNKALKTEFDNEILEIIYQIAEDTNLNFVNSNLYVLINELYQLKLITIAAYLRKLIASGIFYLEPGTHQDLNNLPPVARTHLEILENLPVLNNRQCDSILKKWTPSGFDFKGKFTNGQAMLKKSIIDPIFNNSLSHHENVECTNHIRSLNVGLQFLLINWLTSEIKSTGSSATRLIHFTPAVVTNLYRFYSQTAGLTVFFKVIIPTILKNDGGMIIFYLDTLFLISKLTVRHFKLIKFIAGTHESGCTAYDIFKLIIQAYKDLSTRECDYFKFDHLWNFMDAVTEKAPESMDSNANGGYHNNEQPLNKHSSSLVGKDSLESPMHINTVEVPTTRLHTETRSASKRYTSTDFRNDIAYLRGSVPQSLSSEDAQEVRGAFDTDFSGSELQYWYDNFESLSEEKETGLVKLLRSIMVSDHAFSTKIKDFIVELVKTSTDFQRITTFLKKMSIYDIVRMHELVKILLPVCSELGQESIIDEIILGTEDSETKELTGSQQVLLQLNRHFYRVRSIKPYTMIILRGLLKGGAAYSNDFFFKYKYPVLRFLNLAIATNTKVILSELYVKLPRDDCLELLNIQLGRTEDNFIKTLSDFEKFALEIDEYNLPVCQVLLGVISNSLVSLDFVIVKEQLEHFIGVLLTSMNLRFSDNNSFFGELFSLMVWSHKVCILELLETKFLTETKFDNGIELFVTPTSQQNLLPPLNDFFKKFATSSSSSANSVASDKSLLQRLSDFINKLVEVVNSEAITEPTPNISSAISVFLRILIIHKLSLCEYISSWTTDELVISFVSKLIELLNSNYLSNNADKLRILLYDLLLLMKSGITQEIHSSRDTELSDTTSPQTQPHQPLKQQPQHQDKDDHSEGTSPKSKDSKIENASMVSLIQNLFDLPEPSTANPFSAYLNDGLVKCSIMLDNNELEHGGDISVFNNRGLVLKSTRNDNPELPPFEQNNLMKSKLKQLKEFKFKSFEVLEDIGANSLNDGCLNLQLFDAYTTRENPP
Length1647
PositionKinase
OrganismCandida viswanathii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.279
Instability index39.76
Isoelectric point6.01
Molecular weight188003.98
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.13|      22|      25|    1410|    1434|       1
---------------------------------------------------------------------------
 1410- 1434 (26.70/26.12)	LRILIihKLSLCEYISSwTTDELVI
 1437- 1458 (35.43/19.68)	VSKLI..ELLNSNYLSN.NADKLRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.58|      20|      25|    1547|    1566|       2
---------------------------------------------------------------------------
 1547- 1566 (36.54/23.61)	SAYLNDGLVKCSIMLDNNEL
 1573- 1592 (36.03/23.17)	SVFNNRGLVLKSTRNDNPEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.08|      24|      25|    1343|    1366|       3
---------------------------------------------------------------------------
  430-  448 (22.68/ 9.87)	....LL..LNYFFiDRWATSSSTPA
 1343- 1366 (42.42/25.22)	SQQNLLPPLNDFF.KKFATSSSSSA
 1371- 1394 (35.99/20.23)	SDKSLLQRLSDFI.NKLVEVVNSEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.76|      19|      25|    1473|    1492|       5
---------------------------------------------------------------------------
 1473- 1492 (29.05/21.72)	QEIHSSRDtELSDTTSPQTQ
 1500- 1518 (35.71/22.20)	QPQHQDKD.DHSEGTSPKSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.59|      27|      29|     982|    1009|       6
---------------------------------------------------------------------------
  982- 1009 (42.27/29.38)	VPTTrLHTETRSASKRYTSTDFR.NDIAY
 1014- 1041 (41.32/23.99)	VPQS.LSSEDAQEVRGAFDTDFSgSELQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      31|      31|      15|      45|       7
---------------------------------------------------------------------------
   15-   45 (56.22/30.23)	HSRSSYSNSSTKDEILAMKYLMQEPDLPIYP
   49-   79 (53.96/28.76)	HARKSSSASSTTNVTDTKTHTLQDQVEPAYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      12|      25|    1261|    1273|       8
---------------------------------------------------------------------------
 1261- 1273 (15.84/12.32)	LGVISNSLvSLDF
 1284- 1295 (20.96/11.60)	IGVLLTSM.NLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.78|      21|      26|     879|     903|      10
---------------------------------------------------------------------------
  879-  903 (32.63/28.46)	KLTVRHFKLIkfiaGTHESGCTAYD
  906-  926 (37.15/22.12)	KLIIQAYKDL....STRECDYFKFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.89|      15|      26|    1193|    1207|      11
---------------------------------------------------------------------------
 1193- 1207 (22.79/11.92)	LRFLNLAIA.TNTKVI
 1221- 1236 (20.68/10.13)	LELLNIQLGrTEDNFI
 1318- 1331 (18.42/ 8.23)	LELLETKFL.TETKF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.95|      22|      26|     453|     478|      12
---------------------------------------------------------------------------
  453-  478 (28.89/25.13)	FALPDglrFKLLkLISDTVK.YLFEFN
  482-  504 (37.06/19.07)	FIIPN...YWML.IESSLVKiMLSPFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.24|      14|      29|     537|     551|      13
---------------------------------------------------------------------------
  537-  551 (19.70/16.36)	ANVTvESNRMANRSS
  567-  580 (25.54/16.29)	ANVD.NDYTFINRNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.16|      33|     121|     616|     692|      14
---------------------------------------------------------------------------
  140-  172 (59.09/21.89)	CNTVVKELSAYLTNAYKTR..N...EVINKIRGDSN.HF
  642-  680 (44.07/11.83)	CNFLRNNVLAGLNKALKTEfdNeilEIIYQIAEDTNlNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      16|      25|     391|     406|      17
---------------------------------------------------------------------------
  391-  406 (28.52/20.27)	WLNDVEMNY.GQRLAAL
  413-  429 (22.85/14.58)	WNDLIKVDYlSKELSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.33|      20|      37|     192|     213|      22
---------------------------------------------------------------------------
  192-  213 (30.19/27.79)	LSNCSIPLQK.........IGEKIphGLRNK
  219-  247 (28.14/17.14)	VCSRGVPINRsiwltkcvlYGELI..SLRRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21649 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PLSDHARKSSSASSTTNVTDTKTHTLQDQVEPAY
2) SSRDTELSDTTSPQTQPHQPLKQQPQHQDKDDHSEGTSPKSKDSKI
45
1477
78
1522










Molecular Recognition Features






MoRF SequenceStartStop




1) ILAMKYLMQEPDLPIYPL
29
46