<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21648
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLPFRKTETPLKADPISRVNSSSRLNQLGTTPTSSPSTPNPASYVTSSLNPQKNLPTNATNIKLKLQTQKDLDIFEQLPMVQKVKEYETLLNELSSDISQFKDDHLQLKIQQIIACNDVLKLQIEELNKHRNYSHQVDKLKEENRALENSSKTILKELVGYRNELKKLPKLPRPEKQLNQTVEVDDILKYAFKLAKFTKAPAAVANMPFQIHPNNYIWPAEDSLRRGMLAQASLQPDEIIRNELGVTEKETKEPPTKEDSDEEMEDVVATDEEKPAQAAENRLQQRGSFGGYDAAKKPEEAPAAPADLNLDLFDPDDEYSD |
Length | 321 |
Position | Middle |
Organism | Candida viswanathii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.823 |
Instability index | 47.91 |
Isoelectric point | 5.11 |
Molecular weight | 36321.43 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21648
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.55| 22| 25| 10| 33| 1
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10- 33 (34.84/28.49) PLKADPISRVNSSsrLNQLGTTPT
36- 57 (41.72/27.31) PSTPNPASYVTSS..LNPQKNLPT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 93.44| 25| 26| 148| 172| 2
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124- 141 (21.42/12.31) ........IEELNKHRNYSHQVDKLK
148- 172 (39.29/28.72) ENSSKTI.LKELVGYRNELKKLPKLP
176- 201 (32.73/22.70) KQLNQTVeVDDILKYAFKLAKFTKAP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.59| 19| 24| 266| 284| 3
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266- 284 (31.33/15.10) DVVATDEEKPAQAAENRLQ
293- 311 (32.27/15.73) DAAKKPEEAPAAPADLNLD
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