<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21642

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTVLINNIASIAFRVYESPADTSSHSLASAVLDVENTLRLDGHVVFYDGARRGLWHFQILAQDQVNSNNLNATLDLCGHELVLVEEGLLEPASLQKTRSQQQQPVQTPTSSRSSSSALDQSHRSGLLPLAPPGNPSTSQEQDPSGVELKPTSSSHRLVYENFITALLLSISCTFCRRTSAIPLNYRTLLLLSETLEVGNPLDSCPQQCPIAGTLKAYVTTTGVLIVSLALSRCKGLSSLAELVTSSLPRSGTAVLAAPFGVVANNHLSPAGEPGTASIAQTPITQALSLRVVSDGEDSLWKQACLKVLKLRGVVSSVVADCAWVNLSVPRPRLQDIKPEAKRQQPSSSTVTIPWPSPLCFRKKTVDLPCTSRVGDTLRSVFEESHDPLSSARGWFNSAADREQKVSRRRAERALALKEAQTLEARAPKPSSPSPAAVRRPSAAAGGTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLPAAPSSDFIASTVGDAADMSDEAKRQRVDHNLLGEADDTFGEMGGDMFGDHDITEADFSFFDEQPGDMDLDTAMDTTTLPTEAVREEEAASQCRVTTVPERDDAVFAKPELRHARSSCNDATPGQRGLEARSQPMKREASPFDPHTVYKRLRASLATTTHRRNVKGQPSTRGQRVFDAMKVDASLIRSINKKYEQGGLFDYTKVTRLDKPKAQEAALPETDYLKRHGKQRKRSWNGQFKAETFMKGLMSSEPSGLQAKVDSDDDDSSASSDDDNSSYSAEEPMSPVKSSIKLMPVEDDVASQVTSLRDGDAMEEPDQHLAVELPRLCKPDSPELPLSLLFLDPEPLSLELCLADDDLIQVAQLLTDQAATGLLDMFSAQEGGAAATKLDSPTLATCARNSVQVLRELMPSLLKGAAPVNLKGFLDVADVPLLGQPTRVQQRPVVPGKDPGAEPLRPSNLYQIPGPHLEVRRSETKLSVLPSAVLFWESLGLAPSSGGKDVNAVCVFPGWSGMADNVKAFLGCLKSVYEMLKLGSFERLALPAGLEAGALPYEVDRISTSPGAAVTGALAESMETLLSAVSSADTPAANMVVYFVYSPNMPASIMEACIAFQRLASSYRTRTSTMTATTATTAAAAAAAAAAAAAATPKSPTTQTEVVLQLVSAKLVSSPTCVVVTPAPELVRLSMETYDRCVGKAMPSPAIRLEQPLPRIIDFKLTVSPSASLMRENSCIHIAYAQSIDDRWITAAWTDDRGNRQETASYCLGRKGRPPSRSISDVARDMWELTVDLISVWKVHWRVVITKCSPMDQQEMDFWADRARTEVKASVTMILMTVDTNPSLQLLPPAVKLSATTMTTTMPPTAATTTTTTASPDQTESESEAVLADVTDQTWGAVVSHRFNVSLSALDLRSSSLASGYLIKRTGSRAEDAPVLMEVNLVHADASPRSYEPLLREMLSYFRGLATLARARGVVQREMDVRPWHIAAAEKAVRALYLLM
Length1479
PositionKinase
OrganismOphiocordyceps polyrhachis-furcata BCC 54312
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.238
Instability index50.67
Isoelectric point5.47
Molecular weight159559.82
Publications
PubMed=26511477

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21642
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.51|      19|      22|     562|     582|       1
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  561-  579 (32.84/14.33)	TTTLPTEAV..REE..EAASQCR
  582-  604 (23.67/13.41)	TVPERDDAVfaKPElrHARSSCN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.07|      16|      18|     520|     537|       2
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  514-  532 (28.16/24.67)	DHNllgEAD.DTFGEMGGDM
  535-  553 (24.91/11.68)	DHD.itEADfSFFDEQPGDM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.00|      16|      18|     920|     937|       4
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  919-  936 (24.36/19.71)	QPTRVQQRPVVPGkdPGA
  937-  952 (29.63/16.60)	EPLRPSNLYQIPG..PHL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.02|      12|      18|     472|     483|       5
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  472-  483 (23.29/12.39)	PSMDGTLSSPGN
  489-  500 (21.73/11.07)	PSSDFIASTVGD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.87|      17|      18|     782|     798|       7
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  782-  798 (27.95/15.69)	DD.VASQVTSLRDGDAME
  801-  818 (25.92/13.98)	DQhLAVELPRLCKPDSPE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.30|      36|     258|    1039|    1074|       9
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 1039- 1074 (60.54/39.46)	DRISTSPGAAVTGAL.....AESMETLLSAVS.SADTPAANM
 1300- 1341 (51.76/32.50)	DRARTEVKASVTMILmtvdtNPSLQLLPPAVKlSATTMTTTM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.30|      37|     258|     109|     149|      10
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  109-  149 (61.40/44.08)	QQQPVQTPTSSR...SSSSALDQSHRsgllPLAPP.G..NPSTSQEQ
  369-  411 (49.90/27.09)	RKKTVDLPCTSRvgdTLRSVFEESHD....PLSSArGwfNSAADREQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.54|      22|      22|     665|     686|      11
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  635-  663 (24.10/13.00)	RLRASLATTTHRRNVKGQpstrgqrV..FDA
  665-  686 (36.90/24.33)	KVDASLIRSINKKYEQGG.......L..FDY
  688-  707 (20.54/ 9.85)	KV....TRLDKPKAQEAA.......LpeTDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.17|      21|      22|     288|     308|      12
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  279-  302 (27.17/15.96)	GEpgtASIAQTPITQALSLRVVSD
  303-  323 (36.00/23.73)	GE...DSLWKQACLKVLKLRGVVS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.63|      28|     258|     849|     877|      17
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  849-  877 (43.77/30.53)	LTDQAATGLLDMFSAQEGGAAATKlDSPT
 1109- 1136 (44.87/26.75)	MTATTATTAAAAAAAAAAAAAATP.KSPT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21642 with Med13 domain of Kingdom Fungi
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