<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21634

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSLNDAPTKTFLSLKPVPIADKEPKNLADLISRVNAQPGGFRQLTEAQLRDAIVENDSSNNEDVSVEDVVMVDAANDDDADTTVEDAALARLEVLKNVDCAGNAAMLVLDSLSLLLSKQNPTQASLTLSQQLRDMVGIGTLGVDRLDEPTMDEQRSKDAGQVAIGWTLMEINRTRDAAVKAAALLEKEVDIESRYWSDVMAIKNAGWSICRVPHQRHTLGVRFGFSETSSEFKNSGLAPLRRSEDGSVELDLGRLGGVSECLVVTYLHNDQVVGRSVPTRRRRQGSSSLEARVLEARNTIFAQELWHELIKEARTLAAYDVRLQGSRLRCQTGPDAAIIIELLPLASCPSAEEDESLPHNGVAEAISLGLHILLSYAHRHSELMRTRPMPPHISRSRQQNQTYALLRPVIGRLASTRSIESCTKLVGNLSKALRKAGLASSFILRSPPPAPPADAPSSSHASASQVLVRRLLQPREFAIDFTILTDVSLTLRGRTFLFPITSTHFNATLPPDSPLSPSCVPCPDGYPDLSALAAYLDTTVARALTSHFLARLLSSPSCSRRPWAENVVGTSIVDKESQHWSLRLSAHREDDETSSVVLASTVVYPEDDSRVRRRIWKWTSSSSSPATAGLESESRPLADVVDEAAAMSPS
Length650
PositionHead
OrganismOphiocordyceps polyrhachis-furcata BCC 54312
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.04
Grand average of hydropathy-0.244
Instability index62.31
Isoelectric point5.71
Molecular weight70906.27
Publications
PubMed=26511477

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.73|      13|      38|     239|     251|       1
---------------------------------------------------------------------------
  239-  251 (23.11/12.28)	PLRRSEDGSVELD
  278-  290 (23.62/12.69)	PTRRRRQGSSSLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     200.99|      56|      56|     403|     458|       2
---------------------------------------------------------------------------
  374-  397 (29.17/11.34)	...........................LSYAHRHSELMRT.........RPMPPHISRSR
  403-  458 (94.21/52.11)	YALLRPV.IGRLASTRSIESCTKLVGNLSKALRKAGLASSFILRSP...PPAPPADAPSS
  460-  516 (77.61/41.70)	HASASQVlVRRLLQPREFAIDFTILTDVSLTLR..GRTFLFPITSThfnATLPP.DSPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.15|      26|      50|       4|      29|       3
---------------------------------------------------------------------------
    4-   29 (43.19/29.93)	NDAPTKTFLSLKPVPIADKEPKNLAD
   56-   81 (39.24/26.49)	NDSSNNEDVSVEDVVMVDAANDDDAD
   85-  101 (16.72/ 6.93)	EDAALARLEVLKNVDCA.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      38|     163|     175|       4
---------------------------------------------------------------------------
  163-  175 (24.53/14.74)	AI...GWTLMEINRTR
  201-  216 (21.60/12.22)	AIknaGWSICRVPHQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21634 with Med17 domain of Kingdom Fungi
Unable to open file!