<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21626

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGSDKSNAALSRSLHYWTSFMLSCVNSSPNPEIDEFRNFVRIIYQEYPMPPIFIADVFLKPLYSDITLAPQFPIYIKALTQLGFVDVSSVLLTLCKYSSLNGHVLDPPPTGDDTQLIVTLPDHHGERRSWRVRKFWRLSTWFEEFFFYQLIRFLVDGSAYRDIRSTLMLVKVVCKWMALFTSVSAAFAPDPLTGVQRLRRTEDCEFSRGEEDLVITRAAFLPFLTRLVETPALVDALRHPIAQDIRRELFDTLTRFRQTLPPDTNFSERLDMFRCETLARLNPLPKNRQSDGMDELLEPAMRLENFVIPDIPISNSRAGLYIYLNAAVCHFGLDFYSLVGRPLIDDAMLLSFLHHRYQGETQSGAIDLIVASFDILANTVFRSEGPKDAHLLRSFLINKLPLLLCQLFAAQFSTASSEYCITAALNQVDTSVFPTASLMFDESRSNNPYTESVREDFCTACALHGLVRREHVERILGETSMSYEPSLEKYSKDKLVQSCLSDPDKIQGLVRDIDKMDGNVGAICQALVELIRQLCDSKETMSLKLLCSQLAHKPQSLDILLLFERLPTVLEPLCQLLDNWRYDDDQGEYQPIYEEFGGILLLVLAYAYRYNLRAADIGIVSPDSCVVKILDRAHISRPLNELTEQEKTHVNGWIHGLFGSETGGLGDDLMSSCPPQDFYLIVASLFQYIVAAYTHGYLNDDSLKSGIEYVVDTFLLPSLVPAIRFLADYLWVDQKEQKSVIKILQLILLPSSISGEASAMLSSVKNLIAKPLEYSLRSYQKQDPKNQDIEPLLRALRDNLPLSRRTGGAEHHELDSWSNSSSSGMSGAIRHTVQGLAQMHHGINVMPTSYTHRQTMAACRMVGTSRVLRAMLDEIRQQPEAYDVVAMLVCAPDVTMEPPSSGMLEAAGSAAPQRRLTLREALKAEAESCLKSDKKEEAETIVRLYRRVEAMMALPAAATMLEAPDIPPLNLTGASTGLVDGSMTGVAHGDDGEMMIHRVNLDLALSGASSGLGLGPGPRGGLHAPGDEGMFCRTLDPTMELYWGEGMDTSGE
Length1053
PositionTail
OrganismOphiocordyceps polyrhachis-furcata BCC 54312
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.08
Grand average of hydropathy-0.093
Instability index42.64
Isoelectric point5.20
Molecular weight117715.56
Publications
PubMed=26511477

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21626
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.22|      30|      31|     690|     719|       1
---------------------------------------------------------------------------
  664-  693 (33.90/17.42)	...GGL.GDDLMSSCPPqdfYLIVASLFQYIVAA
  694-  723 (50.86/29.57)	YTHGYL.NDDSLKSGIE...YVVDTFLLPSLVPA
  726-  752 (27.46/12.82)	FLADYLwVDQKEQKSVI...KILQLILLPS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.97|      16|      17|     797|     813|       2
---------------------------------------------------------------------------
  797-  813 (25.68/19.28)	LrDNLPLSRRTG..GAEHH
  815-  832 (25.28/13.75)	L.DSWSNSSSSGmsGAIRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.95|      39|     152|     138|     221|       3
---------------------------------------------------------------------------
  155-  195 (65.60/68.59)	LVDGS....AYRDirSTLMLVKVVCKWMALFTSVSA.AFAPDPLTG
  979- 1022 (59.35/ 7.79)	LVDGSmtgvAHGD..DGEMMIHRVNLDLALSGASSGlGLGPGPRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.18|      32|     152|     347|     421|       5
---------------------------------------------------------------------------
  387-  420 (51.11/80.36)	PKDAHLLrsFLINKLPLL...LCQLFAA.QFSTASSEY
  555-  590 (48.07/ 8.34)	PQSLDIL..LLFERLPTVlepLCQLLDNwRYDDDQGEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      19|      29|     833|     851|       9
---------------------------------------------------------------------------
  833-  851 (35.10/22.62)	TVQGLAQMHHGINVMPTSY
  865-  883 (32.40/20.35)	TSRVLRAMLDEIRQQPEAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.71|      24|      54|     899|     922|      11
---------------------------------------------------------------------------
  899-  922 (40.61/25.87)	PPSSGMLEAAGSAAPQRRLTLREA
  931-  950 (22.42/10.91)	LKSDKKEEAETIVRLYRRVE....
  956-  975 (33.68/20.17)	PAAATMLEAP.DIPP...LNLTGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21626 with Med5 domain of Kingdom Fungi
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