<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21616

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTPGDDGQPLSVRPPPVADRKPRNIADFIARVNAQPGGFRAISEAKLREEIAQENAAGGDSQHKDVDMAEADEDDNDDDDDHDATRDPQEVRMEMFKNLDIAGNTALLTLDFLSLLISKQNPTQAGVTLSQGLRDMVGIGTIGADKLDNPPTTSAKTQEQENIALGFTLMQTNKVRDAAEAASSFLQKEVTSEGNYWEDIIAVQKSGWSITRVPMERHILGVRNSLAPMRRGDGGTVQLDCGKLGGVSERVVVTYEKNGQITGRSALPAETAVDAPLEEHVLEARNTIFSQELWHELTREARSLASYGVKPDGSRLTCDIDPASKSRIILELVPLGTQASSDDHLPDSQVAETISLALHILLGYAHRQNELMRTRPLPPHMARARGQQSHVLLRPIIGRLMHLDNVEVVTKHVGALVQSLQRAGISSRFVLKTPKTSPSDSDPSNQGPHQLASSQTMMRNMLHPIEFNIKLTILPDVTCTVRGRTFHVPVTATYYSVILPPNSPLSSVCAPYKDGYPNPSALAHYLGTATSRLLVEHYLSKLSSPWTRSIQGNVIRNQDNEEFELSFAVTDTPALRVRSTSLVDGKLVRHEWAWSDDTTKESVEAVVDQEIRKIRS
Length616
PositionHead
OrganismFusarium sp. FIESC_28
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.05
Grand average of hydropathy-0.424
Instability index44.53
Isoelectric point5.62
Molecular weight67699.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21616
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.45|      13|      60|     214|     226|       1
---------------------------------------------------------------------------
  214-  226 (24.34/15.82)	PMERHILGVRNSL
  276-  288 (23.11/14.68)	PLEEHVLEARNTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.64|      62|      98|     326|     391|       5
---------------------------------------------------------------------------
  326-  391 (95.59/71.39)	SRIILElVPLGTQASSDdhlPDSQVAETISLALHILLGYAHRQNELMRTRPLPPHMARARGQQSHV
  427-  488 (109.05/68.82)	SRFVLK.TPKTSPSDSD...PSNQGPHQLASSQTMMRNMLHPIEFNIKLTILPDVTCTVRGRTFHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.96|      19|     106|      53|      71|       8
---------------------------------------------------------------------------
   53-   71 (35.45/29.65)	QENAAGGDS..QHKDV.DMAEA
  160-  181 (24.51/17.93)	QENIALGFTlmQTNKVrDAAEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.89|      33|      35|     547|     579|       9
---------------------------------------------------------------------------
  547-  579 (54.74/35.00)	TRSIQGNVIRNQ....DNEEFELSFAVTDTPALRVRS
  580-  616 (47.14/29.23)	TSLVDGKLVRHEwawsDDTTKESVEAVVDQEIRKIRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21616 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRAISEAKLREEIAQENAAGGDSQHKDVDMAEADEDDNDDDDDHDATRDPQEVRMEMF
2) MTPGDDGQPLSVRPPPVADRKPRNIADFIA
39
1
96
30










Molecular Recognition Features






MoRF SequenceStartStop




1) VRPPPVADRKPRNIADFIARVNAQPGGFRAISEAKLREEI
12
51