<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21613

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASIAFRIYEPSSDQSHSFQTSALEIQSTLRDQGKLVSYDADRGGIWVFQITNRDGATKAVNFGSGASIEACGHTLGMVEEGTLEPAALQKSRIPGNTTQNAPANTAATTSSTESHQRNPLISPTQTAGGGALAEGGAQLPAQANDTKTTQPVPKIIYEQFIIAIISSIAFAFCSHSMAIPLNYRTILIPPLQADANEHEKGSLQANPVIGTFKTYLTTTGSLVVSLSFSYCKNLATVEDALSGDSSLPGCSILAAPYGVFATKHGSTNGEADRSLAQTPNTQAMSVRSVPDSHDSLWKHSCLKALEYCGLNPSSFKAGSWVNLLITKPTSQDADGEPKRLRANVPWPGALCFRKKSLEVSTTHRLGETMLSGHEECHDPLGDAREWFGGASEREDRISKRKAERAQAVQKETNGANSQAQNLNGQSPLSVRRPSTAAVGVMYPTPPDAIQQHLGVTPSLDAVISSPNNLPPTLAVVDADITMPTVTPMADVDNDAWEGGHEQKRERSDSNLLGESEDIINDMDGDVFGDHDVTEDDFNFFDGPGDNDMDIDMADLQPISHAPPPQMMPPPIITHPEPQKAIEPQPEVKPKPKHHEPVFAKPELKHARSSLNDELNHKIKTERSNSNKRGSSPFDPDTVFKRVKASLASPTQENFTIQAPLRRKSSIFEKVEFDPKIPLINKKYEQGGAFDFSKEQSGGESKRDVQGLSTDEYLERQGKIKPDSRTLPGASLIRSLTGVDGSTNHANHHKTNGNASFSEDSDIDSEADDLSSLSGGPVSPIKSSVKRTVVDDDALSQATTSREVEFLDDTAEEQLAIELPKLSKTESPEMPLHRFFSDPEPLNTEVGLSNHDFVEVAQIVTEQAATGRLDIGIDHRNESSVSLATMRGHELNIARNSLQLLHSIIPANLGSATAVRLKGLLEILDLPLVGQPNRLQPRPIPGRDTNVEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGAKDVTALCIFPGWKGMADHVGSFTSRLKSVYESLKLGTFNNLALSGDWDDGILPYEIDRISTSPDATITGHGSALVESMEVLRSSLQELKSKDKNLVIYFVYSPDNPASIIEACTTFYRFFDEYSDLLAARRESPQNELVLQLVSSDLISSTTSLVVPSPAEMIKLCLETYDRCTLFLDAEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCIHVGYAESVDGRWITAAWTDNRGQRQATASYSITRSRTPDRSVSQHKAAIMAEIWATTLTMISIWKVHWRVIITKSGPMDQKEVEWWQAASTIDDKYSFTMILMSVDTSPSLQLVPPVVKIPHTATSAFYSTPVSTPQANIVSPEQTTTPATPMRETSTLAATPGAESATEPDADSFLIDATDQTWGAIVGHRLGNSTTLLEVRPALASGYLIKRTGIKIEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVTDREMDVRPWHIAAVEKGVRALHLLL
Length1516
PositionKinase
OrganismFusarium sp. FIESC_28
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.06
Grand average of hydropathy-0.386
Instability index46.67
Isoelectric point5.24
Molecular weight165327.61
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.53|      44|     163|       6|      51|       2
---------------------------------------------------------------------------
    6-   51 (69.09/53.24)	YEtnTLSINNIASIAFRIYEPSSDQSHSFQT...SALEIQSTLRDQGKL
  173-  219 (72.43/49.20)	YE..QFIIAIISSIAFAFCSHSMAIPLNYRTiliPPLQADANEHEKGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.01|      11|      15|     476|     486|       3
---------------------------------------------------------------------------
  476-  486 (20.11/14.25)	DAVISSPNNLP
  493-  503 (20.90/15.20)	DADITMPTVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.87|      21|     117|     509|     531|       4
---------------------------------------------------------------------------
  509-  531 (34.36/28.15)	NDawEGGHEQKRERSDSNLLGES
  627-  647 (38.51/23.42)	ND..ELNHKIKTERSNSNKRGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.10|      31|     117|     319|     349|       5
---------------------------------------------------------------------------
  319-  349 (54.89/34.74)	KALEYCGLNPSSFKAGSWVNLLITKPTSQDA
  434-  464 (55.21/34.99)	QAQNLNGQSPLSVRRPSTAAVGVMYPTPPDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.65|      14|     118|    1207|    1220|       6
---------------------------------------------------------------------------
 1207- 1220 (25.46/17.89)	MIDFKLTTSPSQSL
 1327- 1340 (25.19/17.61)	MILMSVDTSPSLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.29|      43|     384|     363|     405|       8
---------------------------------------------------------------------------
  363-  405 (79.86/49.45)	PGALCFRK.KSLEVSTTH.....RLGETMLSGHEECHDPLGDAREWFGG
  743-  791 (62.43/36.96)	PGASLIRSlTGVDGSTNHanhhkTNGNASFSEDSDIDSEADDLSSLSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     235.09|     107|     384|     970|    1090|       9
---------------------------------------------------------------------------
  225-  282 (50.50/22.63)	IGTFKTYLTttgSLVVSLSFSYCKNLATVEDAlsGDSSLPGC..SILAAPYGVFaTKHGS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  970- 1026 (71.87/42.55)	............................................................tngeadrslaqtpntqamsvrsvpdshdslwkhsclkaleycglnpssfkagswvnllitkptsqdadgepkrlranvpwpgalcfrkkslevstthrlgetmlsgheechdplgdarewfggaseredriskrkaeraqavqketngansqaqnlngqsplsvrrpstaavgvmyptppdaiqqhlgvtpsldavisspnnlpptlavvdaditmptvtpmadvdndaweggheqkrersdsnllgesediindmdgdvfgdhdvteddfnffdgpgdndmdidmadlqpishapppqmmpppiithpepqkaiepqpevkpkpkhhepvfakpelkharsslndelnhkiktersnsnkrgsspfdpdtvfkrvkaslasptqenftiqaplrrkssifekvefdpkiplinkkyeqggafdfskeqsggeskrdvqglstdeylerqgkikpdsrtlpgaslirsltgvdgstnhanhhktngnasfsedsdidseaddlsslsggpvspikssvkrtvvdddalsqattsreveflddtaeeqlaielpklsktespemplhrffsdpeplntevglsnhdfvevaqivteqaatgrldigidhrnessvslatmrghelniarnslqllhsiipanlgsatavrlkglleildlplvgqpnrlqprpipgrdtnveqlrannLYQIPV..PHLEVRRSETklSVLPSS.MSFWEGLGLSP...SWGAKDVTALCI...FPGWKGMADH
 1027- 1080 (60.97/49.51)	VGSFTSRLK...SVYESLKLGTFNNLALSGDW..DDGILPYEidRISTSPDATI.TGHGS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1355- 1418 (51.75/23.48)	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................alvesmevlrsslqelkskdknlviyfvyspdnpasiieacttfyrffdeysdllaarrespqnelvlqlvssdlissttslvvpspaemiklcletydrctlfldaefggptpapavmleqppprmidfklttspsqslmhenscihvgyaesvdgrwitaawtdnrgqrqatasysitrsrtpdrsvsqhkaaimaeiwattltmisiwkvhwrviitksgpmdqkevewwqaastiddkysftmilmsvdtspslqlvppvvkiphtatsaFYSTPVstPQANIVSPEQ..TTTPATpMRETSTLAATPgaeSATEPDADSFLIdatDQTWGAIVGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.79|      13|      15|     533|     547|      10
---------------------------------------------------------------------------
  533-  547 (21.98/19.05)	DIINDMDGDvfGDHD
  551-  563 (27.81/16.58)	DDFNFFDGP..GDND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21613 with Med13 domain of Kingdom Fungi
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