<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21611

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELNVADKELSKGLEEVQTHQNNYLRIQQLRESSAALDAQIRETLSNLATTRKDIVTTHTTTFPAGPSYPIAYEELLNYARRISKTTMPPAGTIKPVPATAAPPTPEGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTLSANTNLPSEWTQFLNPLTDQVFLPWPNDLQLGAGSLAAHQVLLEQGINPKGYDPAEEEERKRREEEEKKKKEEEDRIAQEEREKKIREERERQRIERERQREKDQEAWRRASLVNGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD
Length343
PositionMiddle
OrganismFusarium sp. FIESC_28
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.05
Grand average of hydropathy-1.030
Instability index55.79
Isoelectric point4.85
Molecular weight38364.74
Publications

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP21611
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      15|      15|     255|     269|       1
---------------------------------------------------------------------------
  255-  269 (25.15/15.13)	REEEEKKKKEEEDRI
  271-  285 (24.39/14.47)	QEEREKKIREERERQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.05|      27|      27|     118|     144|       2
---------------------------------------------------------------------------
   92-  115 (39.19/16.45)	HTTTFPAGPSYPI...AYEELLNYARR
  118-  144 (50.09/22.75)	KTTMPPAGTIKPVPATAAPPTPEGQTP
  147-  172 (43.77/19.10)	QTPGPDSQTAS.VMTPSAPPSSQVQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.97|      23|      28|      27|      54|       3
---------------------------------------------------------------------------
   30-   52 (37.16/33.96)	IQQGDELNVA.DKELSKGLEEVQT
   60-   83 (31.80/11.51)	IQQLRESSAAlDAQIRETLSNLAT
---------------------------------------------------------------------------




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP21611 with Med4 domain of Kingdom Fungi

Intrinsically Disordered Regions

IDR SequenceStartStop
1) NVADKELSKGLEEVQTHQNNYLRIQQLRES
2) RISKTTMPPAGTIKPVPATAAPPTPEGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTLSANTNLPSEWTQFLNPLTDQVFLPWPNDLQLGAGSLAAHQVLLEQGINPKGYDPAEEEERKRREEEEKKKKEEEDRIAQEEREKKIREERERQRIERERQREKDQEAWRRASLVNGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD
37
115
66
343

Molecular Recognition Features

MoRF SequenceStartStop
1) AYEELL
2) EAWRRASLVNGPA
3) PPQQKAQFQFTNLDDLDDD
105
298
321
110
310
339