Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELNVADKELSKGLEEVQTHQNNYLRIQQLRESSAALDAQIRETLSNLATTRKDIVTTHTTTFPAGPSYPIAYEELLNYARRISKTTMPPAGTIKPVPATAAPPTPEGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTLSANTNLPSEWTQFLNPLTDQVFLPWPNDLQLGAGSLAAHQVLLEQGINPKGYDPAEEEERKRREEEEKKKKEEEDRIAQEEREKKIREERERQRIERERQREKDQEAWRRASLVNGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Fusarium sp. FIESC_28 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.030 |
Instability index | 55.79 |
Isoelectric point | 4.85 |
Molecular weight | 38364.74 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21611 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.54| 15| 15| 255| 269| 1 --------------------------------------------------------------------------- 255- 269 (25.15/15.13) REEEEKKKKEEEDRI 271- 285 (24.39/14.47) QEEREKKIREERERQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 133.05| 27| 27| 118| 144| 2 --------------------------------------------------------------------------- 92- 115 (39.19/16.45) HTTTFPAGPSYPI...AYEELLNYARR 118- 144 (50.09/22.75) KTTMPPAGTIKPVPATAAPPTPEGQTP 147- 172 (43.77/19.10) QTPGPDSQTAS.VMTPSAPPSSQVQSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.97| 23| 28| 27| 54| 3 --------------------------------------------------------------------------- 30- 52 (37.16/33.96) IQQGDELNVA.DKELSKGLEEVQT 60- 83 (31.80/11.51) IQQLRESSAAlDAQIRETLSNLAT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AYEELL 2) EAWRRASLVNGPA 3) PPQQKAQFQFTNLDDLDDD | 105 298 321 | 110 310 339 |
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