<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21603

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPVPAAAMNGNSTTPNSDVEDASGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEQIQWMSDVNTQLSLRLNLEDFDKIPYHFRNYEINSGRVTFRVPGEFEVDLTIADEDFEKQFWFIDFRFAFHPAVSSIPEGLKNYLEGHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQASQMSKGSWTGTLKVEPLNRALAVQYWTSRTQPGGPKSWVLVAVSTGKKANGQTDPKSSSHLTAKWYRDNKEVKDVVITFDSDNLSAEALIKTVIGRHIDFLLGSIHTKLLSFPRFKNREASLALHSSQEDPADSSLTMEVGFKDRVTLLIEPTTGVFAVKPHSKFTFDKENQLNSGNNPAEDGAACLENVRCAVVEDELSRRGSTAGWSIKKNPLNNDQLKALTNTREWTRTIWLHRAGWGPNWFVMVLLSPGGDVWWLVDTNSSPSGHVPRLSSKLPLNRGFPRLDDEFWNNLTLFASAMIAQMVDQRELHKQNIKFKPHGSNNWSLPQQVRLPTLEIALSGIFPSMVFENAEKDSPRTAGGSSSNAESVKSGSVVQSATGSGISTKQPWANDIISVRFRGVQPAEEASTGYESIKSEGDKSEKPFICVSDAIIKVRRPAKFNMLKSHMVGRDVSWNAGSGEFCLRMRSNIGQSMLENLKARVKAVDRFVSFFESMDQARESIAAESVSLKEVTFSYGPLASEASTDAQPSRLWRITLDLSQKDIDLIIEEPNPHLPVTDLMQKLVNGANGIGALMNWLPESLPALEAIKKIRETWKDIEARNQGQFRFVMDSVDEMSIHYSVTGTGPGNQPLHRDITFLAHVKHRRGEPWWHIMRKSVNINFAPHDEFTSALKPVWEARGEKWTGLVTGAAGRPQDGIANLLFAIDEAIRPLAGSSFQNNSEYVVLD
Length1023
PositionTail
OrganismFusarium sp. FIESC_28
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.08
Grand average of hydropathy-0.362
Instability index36.67
Isoelectric point6.56
Molecular weight114274.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.33|      19|      34|     927|     946|       1
---------------------------------------------------------------------------
  927-  946 (34.83/28.81)	PlHRDIT.FLAHVKHRRGEPW
  960-  979 (34.50/23.17)	P.HDEFTsALKPVWEARGEKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      17|      34|     107|     126|       2
---------------------------------------------------------------------------
  107-  126 (26.93/24.24)	DLRF..........HLQgqeVLFTGALDVM
  132-  158 (24.19/13.03)	DLTFarmpspdlktALQ...VLSTGEAAWM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.06|      27|      34|     472|     502|       3
---------------------------------------------------------------------------
  472-  502 (44.23/38.30)	NP.AEDGAACLENVRCAVVEDELSRrgstAGW
  507-  534 (48.84/31.54)	NPlNNDQLKALTNTREWTRTIWLHR....AGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.37|       9|      34|     192|     201|       4
---------------------------------------------------------------------------
  192-  201 (13.68/11.10)	EDFDKiPYHF
  228-  236 (18.69/10.43)	EDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.71|      19|      30|     851|     869|       7
---------------------------------------------------------------------------
  851-  869 (31.43/18.41)	LPVTDLMQKLVNGANGIGA
  878-  896 (31.28/18.29)	LPALEAIKKIRETWKDIEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.20|      23|      34|     729|     751|       9
---------------------------------------------------------------------------
  690-  721 (23.61/12.43)	ISVRfrgvQPAEeastgYESIKS.....EGDKSEKPF
  729-  751 (40.63/26.72)	IKVR....RPAK.....FNMLKS.....HMVGRDVSW
  760-  787 (28.97/16.93)	LRMR....SNIG.....QSMLENlkarvKAVDRFVSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21603 with Med14 domain of Kingdom Fungi
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