<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21601

Description Uncharacterized protein
SequenceMTSRTPMSAHPRPPQRSVSSSSLPIQRPPPQRTLSHQQQFMPASPVRKDSSFIDLTADAGDATPNRYNTTPRRGGSRLRLELSHNASASSFPASESPQSLTPSRIPTNSDPFQSMVGSPAPINSASSTSMPMPTRRPVTSQLKSAPPTTTTTAPTPVKKDARLKPYTVEIPSAAPRYFAANRPETTSRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGEKDWKTRVTYAIRLATNLYAEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLKFRKYGRRLVFALLSHLHVTYNDPDQDLLVQLSSRLSTLLGSLVLSNPESFINPGAWPRYKDTLQASLRTDHEPTQKAIHTINYRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDGHLAPACWATSENKPLIMKTVVEWATSFHRPGLAKVYAASQLIRQWSQFRVDPTTPILETLDSIAIEDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHSGVEIDAESGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSIVEEEQDIANAIKYVRHTVGLPLPPGDPLSERKPISLKKLLPRIGSSSSALRSSIGAHLRDVLTGQLNYKSQPSLPLTMYNSVRAIMETAEDYSMLSDILGACAKTADYDVLASVADTVHSNLQIFSALGSANDLFSILIERLKSMNDEQGIVPRPFLAALSSLAQRMTGHEVIASHLRQELLQSDRSNAIDACSPVSDIVAAPAQHAENELAEDIEKQLSSGTRLDPPTMNKLFRRIIPALERGWEKTDDTRRVFATLLTRIRVFDAHHFDKLMTDWTSHVRSLPNRSPLVGLFPLLVSTGCLTMPILMSTASPPSASFQNLPSDPMENKFSPATYLQELLQLVIMPLPTGTGLSTEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSALRHYANGLEFPLDNSVCQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGDTQISFDRILQIANELTLPFCQLKLNLDLSLPQPNASEGQFEIFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQSVFLDLIPSSKTSEIADTGSRQSLRMAENLLEVVEAIISGQPPPKMAQLSSGMVEKLTDLWEIIAAGPQERPSCHTAVLQHWLPAMLRFVTLHSLSSEPPSAPLPTASATRPPIPPVHDTRARIVLVLCGLLLELETLPPATVGSLPQQVFDIAILLVDALPEDLRANCAKTILLTSGGLPNQGTSSDPRLYYLFSSPPPSVSDNLMLSHREKAATPQGAVARGMGAQYGIGPAVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1526
PositionKinase
OrganismFusarium sp. FIESC_28
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.06
Grand average of hydropathy-0.227
Instability index51.68
Isoelectric point8.81
Molecular weight168055.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21601
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     241.34|      62|      97|     808|     875|       1
---------------------------------------------------------------------------
  808-  871 (92.88/57.08)	SMLSDILGACAKTADYDVLASVADTVHSNLQIfsALGSANDLFSILIERLKSMNDEQGIVPRPF
  909-  970 (105.25/55.87)	SPVSDIVAAPAQHAENELAEDIEKQLSSGTRL..DPPTMNKLFRRIIPALERGWEKTDDTRRVF
 1278- 1313 (43.21/20.37)	.............AEN.LLEVVEAII.SGQ....PPPKMAQLSSGMVEKLTDLWE.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.10|      30|      47|     685|     714|       2
---------------------------------------------------------------------------
  685-  714 (51.85/31.50)	RLLVELPL...HALSEKKRAERGNLLRRAGNYS
  730-  762 (48.25/28.76)	RHTVGLPLppgDPLSERKPISLKKLLPRIGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.55|      50|      97|     483|     532|       3
---------------------------------------------------------------------------
  469-  513 (66.67/33.54)	.....TYNDPDQDLLVQLSSRLSTLLGSLVLSNPESFINPGAWPRYKDTL
  514-  557 (68.37/34.57)	QASLRTDHEPTQKAIHTINYRNS....RLVVSSTAS..PPAGRSQLVKLL
  558-  607 (76.51/39.53)	DAALKESSDGHLAPACWATSENKPLIMKTVVEWATSFHRPGLAKVYAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.42|      78|     192|    1147|    1265|       4
---------------------------------------------------------------------------
 1163- 1265 (107.80/120.55)	TKLLIPgDSGDTQIsfdRILqianeltLPFCQLKLNLD.......LSLPQpnasegqfEIFAKAMD.........RAIEAGNIMWTS.LLPclsddiTQHLKSQAQSVFLDLIPSSKTSE
 1361- 1455 (122.61/60.13)	TRPPIP.PVHDTRA...RIV.......LVLCGLLLELEtlppatvGSLPQ........QVFDIAILlvdalpedlRANCAKTILLTSgGLP......NQGTSSDPRLYYLFSSPPPSVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.28|      40|      47|      71|     110|       5
---------------------------------------------------------------------------
   14-   58 (53.00/22.10)	PQRSVSSSSLPiqrpppqrtLSH..QQQFMPA..SPVRKDSSFIDLTAD
   71-  110 (66.52/29.51)	PRRGGSRLRLE.........LSHNASASSFPASESPQSLTPSRIPTNSD
  121-  160 (64.76/28.54)	PINSASSTSMP.........MPTRRPVTSQLKSAPPTTTTTAPTPVKKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.26|      25|      41|     292|     320|       7
---------------------------------------------------------------------------
  292-  320 (35.17/39.82)	KREVWLKDLAnPAISLRRLSRtipHGIRG
  335-  359 (45.09/32.84)	ERAVWLAKCV.GANEIRGLKR...KGVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.45|      33|      38|     382|     418|      15
---------------------------------------------------------------------------
  382-  418 (42.50/36.47)	DAVVAGFgEKDwkTRVTYAIrLATNLYAEQLLDRDHY
  420-  454 (56.95/37.71)	DWVVSGI.ENSlqSRIPMWL.LIAQIYWKDLLKFRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.29|      37|      38|    1020|    1057|      16
---------------------------------------------------------------------------
 1020- 1057 (59.90/42.30)	MPILMSTASPPSASFQnLPSDPMENKFSPATYLQELLQ
 1061- 1097 (63.39/40.13)	MPLPTGTGLSTEESYR.FHTEQKCAKFEQSKGLLNLVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21601 with Med12 domain of Kingdom Fungi
Unable to open file!