<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21596

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASVAFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDAERVGIWIFQIVSKDGTSSLVSSAPGSSLEASGYTLGMVEEGTLEPVALQKSRIPGNTTQNAPNNTASTSSPAEANSRNPLISPTQVAGGALPDGGSQSSAQATDMRTPRIVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLQADANDRERGSLQADPVVGTFKTYLTTTGSLVVSLTFAYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGPDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKSSPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPLEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGAPEREERISKRRAERMYAIPKEVNGANPVAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGVAPSLDGAIPSPNNPPPTLAVVDADITMPTATSMPDAENDAWGGHHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPLLSHPQPHKAIEPQPEVKPKPKINDSVFAKPELKHARSSLNEELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDYAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQRNEDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDTSTTHASPQRLSGHDWISEESDLESDGDDISSLSGGPVSPVKSSIKRTVVDDDVLSQATTSRETELLDDFTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGLEHKAESSVSLATMRSHELNIARNSLQLLHDVMPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGPKDISALCIFPGWKGISDHVESFLGRVKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSQHKAAIIAEIWATTLTMISIWKVHWRVIITKSGVMDQREVEWWQAASTLDDKHSFTMIIMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGTKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1515
PositionKinase
OrganismGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.385
Instability index49.91
Isoelectric point5.19
Molecular weight165491.18
Publications
PubMed=30202022

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21596
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     793.18|     246|     283|     277|     559|       1
---------------------------------------------------------------------------
  139-  294 (120.93/62.63)	...........................................................................................................................................................PTQVaGGAL..PDGGSQS......SAQATDMRTPRIVPK.IIYE.QFIVAVISSIAFAfC.......................SRSMAIPL.NYRTMLIPPLQADANDRERGS....L...QADPVVGTFKTYLTTTGSLVVSLTFAYCK..NLAtvEDV.LtGDssspsSSVLAAPYGVFatkqnfangdgpDRS........LAQT
  295-  574 (380.38/238.20)	PNTQALSVRSVPDTNDSQwKHsclKALEYcglNPsQFKSSPWVN.LLISKPTSQDAD...GESKRSRATVPWP.....GSlcfrkKPLEMSTT.HRVGDTMLSgheechdPLGDArgwFAGAPER...........EERIS..KRRAER..MYAIPKEV.NGAN..PVAQNLN......GQSPLTMRRPSTAAAGVMYP.TPPDAIQQHIGVA.P.......................SLDGAIPSPNNPPPTLAVVDADITMPTATS....MPDAENDAWGGHHEQKRERSDSNAMGDSDDVMN..DLG..EDV.F.GD.....HDVTEDDFNFF.........dgpDGNdldmdmpdLQPA
  575-  869 (291.87/138.22)	PTAPAPQVMPPPLLSHPQ.PH...KAIEP...QP.EVKPKPKINdSVFAKPELKHARsslNEELNHRIKVERPdtakrGS.....SPFDPATVfKRVRASLSS.......PTKDD...YAVQPPRrkssvfekvefDPKIPliNKKYEHggAFDFSKDQ.RNEDsrPSAHNLSrdeyleGQGKLKQTSKSLLGNSLIRSlTGIDTSTTH..AS.PqrlsghdwiseesdlesdgddisSLSGGPVSPVKSSIKRTVVDDDVLSQATTSreteLLDDFTDEQLAIELPKLSKTESPEMLLHRFFLDpePLN..VDVgL.SN.....HDFVE.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.81|      70|     244|    1106|    1229|       2
---------------------------------------------------------------------------
 1152- 1229 (112.67/141.56)	LDMISSTTSLVVPTpaemiKLCIET...YDRCTL...FLDTEFGGPTPAPAVMLEqppPRMIDFKLTTSPSQSLMHENSCLHVG
 1404- 1479 (113.15/51.33)	IDATDQTWGAIVGH.....RLCNSTtllEVRPALasgYLIKRTGTKLEDPPVVME...VNLVHTEATPRAYEPLLREMLCYFRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.09|      18|     283|     765|     785|       6
---------------------------------------------------------------------------
  765-  785 (24.83/25.09)	LSGhDWisEESDLESDGDDIS
 1050- 1067 (35.26/21.31)	LSG.DW..DDGVLPYEVDRIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21596 with Med13 domain of Kingdom Fungi
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