<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21593

Description Uncharacterized protein
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSVSLPTSESPQSLTPSRIPNSDPFQAMVGSPADSASSTLMPMPTRRPVTSQPRFAPRITATGPAPTKKDVRPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLGHLHVISNDPDKDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKSLHAINSRNSALVVSSTASPPAGRSQLVKLLDAALKESSGNHLAAACWATSENKALIMRTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDNIAPNDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSVAEEEQDITNAIRVVKLVVGLPLLSNDPLSGRKPMSLKRLLQRIGGSSTAVRSSIGAHLRDELTGHFIMKGHSLSLTMFTAVRDIMETTEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFYAMDSADELFSSLTERLRMMNEEQRLVPRPLLAALDSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVLATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSPLSTLFPLLIITGCLTMPIIMSTASPPFATVQSLAPDSSRGPATYLQELLQLVIMPLPRGTGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSAVRNHVSGTEFPLGNIECQESLLETLRTLVLVDSSAVSNALGIKALPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVNEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLELIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLIDLWEIVAAGPQARPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETQPPATVGSLVQQVFDIAILLVDALPEELRANCARAILLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNIMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1519
PositionKinase
OrganismGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.188
Instability index52.06
Isoelectric point8.86
Molecular weight167134.54
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21593
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     278.92|      94|     101|     762|     862|       1
---------------------------------------------------------------------------
  730-  778 (27.37/17.87)	........................................................SNDPLSgrkpMSLKRLL.QRIGGSS..TAVRSSIGAHLrDELTGHfiMKGHS
  779-  876 (142.35/91.89)	LSLTMFTAVRDimETTEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIfyAMDSADELF....SSLTERL.RMMNEEQ..RLVPRPLLAAL.DSLAQR..MAGHE
  882-  964 (109.20/59.31)	LRQELVQNDRN..NAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRL..DPPTMNKLF....RMIIPALeRGWEKEDdtRRVLATLL.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.69|      24|     101|       8|      34|       2
---------------------------------------------------------------------------
    8-   34 (38.53/27.23)	PQRSVSSSSLPVqrpPPQRSLSHQQQF
  113-  136 (45.16/23.74)	PADSASSTLMPM...PTRRPVTSQPRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.18|      57|      96|    1287|    1347|       3
---------------------------------------------------------------------------
 1287- 1347 (101.21/70.14)	PPKmaqlSLG.MVEKLIDL.WEIVAAGPQA.RPNCHAAVL..QHWLPAMLRFVN..LHSLSSEPPSAP
 1383- 1446 (81.96/48.13)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARAILltPGGMPNQGTSSDprLYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.31|      27|      96|     474|     500|       4
---------------------------------------------------------------------------
  474-  500 (45.96/23.42)	SRLSALLGSLIRSNPESFINPG............AWSTY
  524-  540 (20.72/ 6.80)	SRNSAL...VVSSTASP...PA............G....
  542-  567 (32.56/14.59)	SQLVKLLDAALKESSGNHLAAA............CWAT.
  571-  606 (28.07/11.64)	...KALIMRTVVEWATSFHRPGlakvyaaarlirQWSQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.04|      14|      40|     295|     311|       7
---------------------------------------------------------------------------
  295-  311 (19.48/17.00)	AISLRRLSRtipHGIRG
  337-  350 (24.55/12.29)	ANEIRGLKR...KGVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.58|      28|      34|     381|     409|      10
---------------------------------------------------------------------------
  381-  409 (45.07/27.69)	ENDWKNRVTYAIrLATNLYSEQLLDRDHY
  418-  445 (50.51/27.13)	ENSLQSRIPMWL.LIAQIYWKDLLRSRKY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21593 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSVSLPTSESPQSLTPSRIPNSDPFQAMVGSPADSASSTLMPMPTRRPVTSQPRFAPRITATGPAPTKKDVRPKPY
1
157










Molecular Recognition Features






MoRF SequenceStartStop




1) RLYYLF
1434
1439