Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKYIDGHFERLEKALANLIDSVTKYHPSIQQGEELNAADQELSRGLEEVQTHQNNYLRIQQLRESSNALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPSYPIAYAELLNYARRISKTTMPPAGTIKAVPPTADVPEVQTPGGQTPAAQTPGPESQAASVMTPSAPPSSQVQSPAIMNGTPAVSQELATQQSSMSANTVLPSEWTQFLNPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKHKEEEDRIAQEEREKKQREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 346 |
Position | Middle |
Organism | Gibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.034 |
Instability index | 63.80 |
Isoelectric point | 4.71 |
Molecular weight | 38722.00 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21590 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 66.92| 19| 29| 251| 269| 1 --------------------------------------------------------------------------- 251- 269 (33.46/23.17) EEEERKRREEEERKHKEEE 275- 293 (33.46/23.16) EEREKKQREERERQRIERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 61.64| 13| 15| 152| 164| 2 --------------------------------------------------------------------------- 137- 147 (17.33/ 6.85) ..PEVQTPGGQ..TP 152- 164 (24.56/12.44) PGPESQAASVM..TP 168- 182 (19.75/ 8.72) PSSQVQSPAIMngTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 84.61| 27| 29| 30| 56| 3 --------------------------------------------------------------------------- 30- 56 (45.23/27.32) IQQ.GEELNAADQELSRGLEEVQTHQNN 60- 87 (39.38/22.92) IQQlRESSNALDTQIRDTLSNLATTRKD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DQEAWRRASLVGGPA 2) QQKAQFQFTNLDDLDD | 299 326 | 313 341 |
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